Research
Chlorogenic Acid
45 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of chlorogenic acid and its isomers on growth performance and antioxidant function of broilers: a meta-analysis.
Meta-analysis of 15 studies (50 records) evaluating the effects of chlorogenic acid and its isomers on broilers. CGA and its isomers significantly enhanced growth performance and antioxidant capacity, improving average daily gain, feed conversion ratio, and serum antioxidant enzyme activities under both normal and stress conditions.
Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials.
Systematic review of chlorogenic acid (CGA), a polyphenol found in plants like green coffee beans, highlighting its therapeutic effects on chronic metabolic diseases and age-related disorders. CGA exhibits neuroprotection, anti-inflammation, anti-oxidation, and cardiovascular benefits, acting through pathways like NF-kB, Nrf2, and AMPK.
Impact of coffee-derived chlorogenic acid on cognition: a systematic review and meta-analysis.
Systematic review and meta-analysis of studies on coffee-derived chlorogenic acid (CGA) and cognitive performance. The meta-analysis of RCTs showed no benefits of coffee CGA intake on cognitive function, though the review suggests chronic consumption may be needed for potential benefits.
Chlorogenic acid in green bean coffee on body weight: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs examining the effect of green bean coffee extract containing chlorogenic acid (500 mg/day) on body weight. The analysis included three RCTs with 103 individuals and found that GBCE with CGA results in body weight reduction without study heterogeneity or publication bias.
The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review.
This systematic review examines the regulatory effects and mechanisms of chlorogenic acid (CGA) on gut-brain function. It reviews CGA metabolism and its roles in the intestine and brain, speculating on its potential actions in the gut-brain axis. The review aims to support CGA research in food nutrition and health care.
Effects of Caffeinated and Decaffeinated Coffee Consumption on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis of Data from Randomised Controlled Trials.
This systematic review and meta-analysis evaluated the effects of coffee consumption on metabolic syndrome parameters. Green coffee extract supplementation was found to reduce waist circumference, triglyceride levels, and blood pressure, while decaffeinated coffee reduced fasting blood glucose levels. The effects varied depending on the types and doses of coffee administered.
The effect of green coffee extract supplementation on anthropometric measures in adults: A comprehensive systematic review and dose-response meta-analysis of randomized clinical trials.
Comprehensive systematic review and dose-response meta-analysis of 15 RCTs with 897 participants on the effects of green coffee extract supplementation on anthropometric measures. GCE supplementation significantly reduced body weight, BMI, and waist circumference, but had no significant effect on body fat percentage and waist-to-hip ratio.
The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials.
Systematic review and meta-analysis of 14 clinical trials with 766 participants examining the effects of green coffee extract supplementation on glycemic indices and lipid profile. GCE supplementation significantly reduced fasting blood glucose, serum insulin, and total cholesterol levels, with additional improvements in triglycerides, LDL, and HDL in certain subgroups.
The effect of green coffee extract supplementation on lipid profile: A systematic review of clinical trial and in-vivo studies.
Systematic review of clinical and in-vivo studies on the effect of green coffee extract (GCE) and chlorogenic acid (CGA) on lipid profiles. The review included 32 studies, finding controversy about the lipid profile improvement effects of GCE and CGA. Higher dosages and longer administration may lead to better results, but further studies are needed.
The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of RCTs evaluating the effect of chlorogenic acid on blood pressure. Meta-analysis showed significant reductions in both systolic and diastolic blood pressure favoring chlorogenic acid. The studies included 364 participants and reported no adverse events.
Safety and Tolerability of HemoHIM: A Randomized, Placebo-Controlled, Double-Blind, and Parallel Clinical Trial in Healthy Human Volunteers.
RCT of 96 healthy adults assessing the safety and tolerability of HemoHIM, a mixed extract from oriental medicinal herbs. Participants consumed 40 g/day of HemoHIM or placebo for 8 weeks. No clinically significant changes were found in safety tests, suggesting HemoHIM is safe for human use.
Clinical Evaluation of a Novel, Patented Green Coffee Bean Extract (GCB70®), Enriched in 70% Chlorogenic Acid, in Overweight Individuals.
RCT evaluating the safety and efficacy of a novel green coffee bean extract (GCB70) enriched in chlorogenic acid in 105 overweight individuals over 12 weeks. GCB70 supplementation significantly reduced body weight, BMI, waist circumference, plasma leptin, fasting glucose, and HbA1c levels, while also decreasing TSH levels, demonstrating its potential in healthy weight management.
A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study.
A 6-month RCT of 50 pre-obesity subjects receiving Altilix® supplement containing chlorogenic acid and luteolin. The supplement significantly reduced body weight, glycemic, and lipid parameters, and improved hepatic functionality, CIMT, and FMD.
The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature.
This systematic review discusses in vivo animal and human studies on the physiological and biochemical effects of chlorogenic acids (CGAs) on biomarkers of chronic disease. It highlights CGA's potential roles in glucose and lipid metabolism regulation and its impacts on diabetes, cardiovascular disease, obesity, cancer, and hepatic steatosis.
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up.
Phase I open-label, dose-escalation trial of injectable chlorogenic acid (CGA) in 26 patients with recurrent high-grade glioma. CGA was well tolerated with a maximum tolerated dose of 5.5 mg/kg. 52.2% of patients achieved stable disease, with a median overall survival of 11.3 months.
Acute cognitive performance and mood effects of coffee berry and apple extracts: A randomised, double blind, placebo controlled crossover study in healthy humans.
This randomised, double-blind, placebo-controlled crossover trial investigated the effects of coffee berry and apple extracts on cognitive performance and mood in 46 healthy adults. The study found alerting effects and some improvements in executive function and accuracy on cognitive tasks with high-dose coffee berry extract, but limited effects on mood.
AltilixSupplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study.
A 6-month randomized, double-blind, placebo-controlled study evaluated the effects of Altilix, containing chlorogenic acid and luteolin, on cardiovascular risk and hepatic markers in 100 subjects with metabolic syndrome. Altilix supplementation significantly improved body weight, waist circumference, HbA1c, plasma lipids, fatty liver index, hepatic transaminases, flow-mediated dilation, and carotid intima-media thickness compared to placebo.
Development of an LC-MS/MS method for quantitative analysis of Chlorogenic acid in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor.
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for determining chlorogenic acid in human plasma. This method was applied to a pharmacokinetic study in Chinese patients with advanced solid tumors after intramuscular injection of chlorogenic acid.
Dietary chlorogenic acid regulates gut microbiota, serum-free amino acids and colonic serotonin levels in growing pigs.
RCT investigating the effects of chlorogenic acid (CGA) on gut microbiota, serum-free amino acids, and colonic serotonin levels in 96 growing pigs. CGA supplementation increased gut microbiota diversity, serum free amino acid levels, and colonic serotonin levels compared to control.
A randomised placebo-controlled trial to differentiate the acute cognitive and mood effects of chlorogenic acid from decaffeinated coffee.
RCT with 60 healthy older adults comparing decaffeinated green coffee blend (GB), pure chlorogenic acids (CGA), and placebo. GB improved sustained attention and alertness compared to placebo, while CGA did not significantly improve cognitive function. Both GB and CGA improved headache symptoms compared to placebo.
Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial.
Randomized controlled crossover trial with 34 MCI patients evaluating the effects of chlorogenic acid (CGA) intake on cognitive function. CGA intake significantly reduced errors in the TMT-B test, indicating improved attention and executive function, but no significant differences were found in MMSE, ADAS-cog, or TMT-A scores.
Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: a pilot study.
A placebo-controlled double-blind pilot study with 16 healthy Japanese men investigated the effect of chlorogenic acid-enriched green coffee bean extract on arterial stiffness using the cardio-ankle vascular index (CAVI). The cGCE group showed a significant improvement in CAVI, increased flow-mediated dilation, and decreased sympathetic nervous activity compared to placebo, suggesting improved arterial stiffness.
Influence of 2-Weeks Ingestion of High Chlorogenic Acid Coffee on Mood State, Performance, and Postexercise Inflammation and Oxidative Stress: A Randomized, Placebo-Controlled Trial.
This RCT measured the influence of 2-weeks ingestion of high chlorogenic acid coffee on postexercise inflammation, oxidative stress, performance, and mood state in 15 cyclists. CQA coffee improved mood scores but did not significantly affect postexercise inflammation, oxidative stress, or cycling performance compared to placebo.
Effects of Chlorogenic Acid-Enriched and Hydroxyhydroquinone-Reduced Coffee on Postprandial Fat Oxidation and Antioxidative Capacity in Healthy Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
This randomized, double-blind, placebo-controlled, crossover trial assessed the effects of chlorogenic acid-enriched and hydroxyhydroquinone-reduced coffee on postprandial fat oxidation and antioxidative capacity in 15 healthy men. The study found that reducing hydroxyhydroquinone in coffee enhanced postprandial fat oxidation and improved the antioxidative capacity of chlorogenic acids.
Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function.
Double-blind, placebo-controlled study of 49 female subjects with mildly xerotic skin receiving a beverage containing coffee polyphenols (CPPs) or placebo for 8 weeks. CPPs significantly improved skin dryness, hydration, and microcirculatory function.
Effect of Chlorogenic Acid Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance.
A randomized, double-blind, placebo-controlled clinical trial in 30 patients with impaired glucose tolerance evaluated the effects of chlorogenic acid. The chlorogenic acid group showed significant decreases in fasting plasma glucose, insulin secretion, body weight, and lipid profile, with an increase in insulin sensitivity, compared to placebo.
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials.
Two randomized, controlled, crossover intervention trials investigated the impact of coffee intake rich in chlorogenic acid on human vascular function. Coffee intake improved flow-mediated dilatation (FMD), with effects mediated by chlorogenic acid and its metabolites.
Effect of emulin on blood glucose in type 2 diabetics.
RCT evaluating the effect of Emulin, a blend of chlorogenic acid, myricetin, and quercetin, on blood glucose levels in 40 type 2 diabetic humans. Emulin, both alone and in combination with metformin, reduced fasting blood glucose, 2 h postprandial, actual peak glucose, and AUC compared to placebo, with the Emulin/metformin group showing the most significant reductions.
Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men.
Randomized controlled crossover trial in 10 healthy volunteers assessing the effects of chlorogenic acid-rich coffee on fructose-induced liver insulin resistance. Coffee consumption attenuated hepatic insulin resistance but did not alter the increase of intrahepatocellular lipids induced by fructose overfeeding.
Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial.
Randomized, double-blind, placebo-controlled, crossover trial in 23 healthy volunteers studying the acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure. Chlorogenic acid significantly lowered systolic and diastolic blood pressure but did not significantly influence nitric oxide status or endothelial function.
Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.
Randomized crossover trial evaluating the acute effects of decaffeinated coffee, chlorogenic acid, and trigonelline on glucose tolerance in 15 overweight men. Chlorogenic acid and trigonelline significantly reduced early glucose and insulin responses during an OGTT compared with placebo.
The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.
Clinical study with 12 healthy volunteers showed that instant coffee enriched with chlorogenic acid reduced glucose absorption by 6.9% compared to control. A 12-week RCT with 30 overweight individuals found that chlorogenic acid enriched coffee led to an average weight loss of 5.4 kg, compared to 1.7 kg with normal coffee.
Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans.
The study evaluated the absorption and metabolism of chlorogenic acids (CGA) from coffee in 6 healthy adults. It identified various CGA isomers and metabolites in plasma and urine, showing differential absorption and metabolism with significant inter-individual variation.
Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study.
A 4-week randomized placebo-controlled clinical trial investigated the effect of 300 mg Blueberin on fasting plasma glucose, CRP, and plasma aminotransferases in 42 female volunteers with Type 2 diabetes. Blueberin significantly reduced fasting plasma glucose and CRP levels, as well as plasma enzymes ALT, AST, and GGT, indicating anti-diabetes and anti-inflammatory effects.
The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.
Placebo-controlled RCT examining the blood pressure-lowering effect and safety of chlorogenic acid (CGA) from green coffee bean extract in 28 patients with mild hypertension. The CGA group showed significant decreases in systolic and diastolic blood pressure with no apparent side effects.
Green coffee bean extract improves human vasoreactivity.
RCT evaluating the effects of green coffee bean extract (GCE) on vasoreactivity in 20 healthy males. The test group showed improved reactive hyperemia ratio and decreased plasma total homocysteine levels after 4 months, suggesting enhanced vasoreactivity.
Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine.
A 3-way, randomized, crossover study with 9 healthy volunteers examined the effects of chlorogenic acids in coffee on glucose uptake and gastrointestinal hormone secretion. Caffeinated coffee increased glucose and insulin concentrations initially, while decaffeinated coffee altered gastrointestinal hormone profiles, suggesting delayed intestinal glucose absorption.
Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans.
Crossover study with 20 healthy men and women ingesting chlorogenic acid, black tea, quercetin-3-rutinoside, or placebo for 7 days. Chlorogenic acid and black tea increased plasma total homocysteine concentrations, suggesting a potential negative impact on cardiovascular health.
New insights into the inhibitory effect of phenol carboxylic acid antioxidants on mushroom tyrosinase by molecular dynamic studies and experimental assessment
The study investigates the inhibitory effects of ferulic and chlorogenic acids on tyrosinase activity using multi-spectroscopic and molecular docking techniques. Both acids demonstrated reversible and competitive inhibition of tyrosinase monophenolase activity, with potential applications in food and drug industries as tyrosinase inhibitors.
Mechanistic Insights into Effects of Different Dietary Polyphenol Supplements on Arsenic Bioavailability, Biotransformation, and Toxicity Based on a Mouse Model.
This study investigated the effects of chlorogenic acid, quercetin, tannic acid, resveratrol, and epigallocatechin gallate on arsenic bioavailability, biotransformation, and toxicity in a mouse model. Intake of certain polyphenols increased arsenic concentrations in liver and kidneys but reduced cancer risk markers, suggesting potential dietary strategies to mitigate arsenic toxicity.
Ultrasound-Assisted Aqueous Extraction of Chlorogenic Acid and Cynarin with the Impact of Inulin from Burdock (Arctium lappa L.) Roots
The study investigates the ultrasound-assisted aqueous extraction of chlorogenic acid (CGA) and cynarin with the impact of inulin from burdock roots. Different extraction modes were compared, and the effects of process parameters on the extraction of polyphenols, CGA, cynarin, inulin, and antioxidant activity were evaluated. The study provides an effective method using water to extract these compounds from burdock roots.
Mulberry leaf polyphenols attenuated postprandial glucose absorption via inhibition of disaccharidases activity and glucose transport in Caco-2 cells.
The study evaluated the mechanism of mulberry leaf polyphenols (MLPs) in type-2 diabetes prevention by inhibiting disaccharidase and glucose transport in Caco-2 cells. MLPs showed strong inhibitory effects on sucrase activity and glucose transport, suggesting potential benefits in lowering postprandial glucose levels.
Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay.
In vitro study using a Caco-2 cell line model to investigate the intestinal absorption of chlorogenic acid and quinic acid. The study demonstrated the involvement of an active efflux mechanism, suggesting low intestinal absorption for both compounds.
Effects of chlorogenic acid-enriched extract from Eucommia ulmoides leaf on performance, meat quality, oxidative stability, and fatty acid profile of meat in heat-stressed broilers.
The study investigated the effects of chlorogenic acid-enriched extract from Eucommia ulmoides leaf on heat-stressed broilers. Supplementation at 1,000 mg/kg improved growth performance, meat quality, oxidative stability, and fatty acid profile in broilers under heat stress.
Chlorogenic Acid from Hawthorn Berry (Crataegus pinnatifida Fruit) Prevents Stress Hormone‐Induced Depressive Behavior, through Monoamine Oxidase B‐Reactive Oxygen Species Signaling in Hippocampal Astrocytes of Mice
The study investigated the antidepressant-like effects of chlorogenic acid (CGA) from Crataegus pinnatifida fruit in mice. CGA prevented stress hormone-induced depressive behavior by inhibiting monoamine oxidase B activity and reducing reactive oxygen species production, suggesting its potential as a natural antidepressant.