Research
Chinese Asparagus (Tian Men Dong)
21 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Fermentation of Asparagus cochinchinensis extracts with endophytic Aspergillus aculeatus TD103 enhanced their photo-protective effects against UVB radiation.
The study investigated the photoprotective properties of Asparagus cochinchinensis extracts fermented with Aspergillus aculeatus TD103. The fermented extracts showed enhanced radical scavenging, reduced ROS, increased antioxidant enzymes, and improved collagen-related markers in UVB-induced HaCaT cells, suggesting potential for cosmeceutical applications.
Identification of active anti-aging ingredients from asparagus cochinchinensis based on the spectrum-effect relationship.
The study evaluated the anti-aging effects of Asparagus cochinchinensis-derived total saponin extracts (ATSE) in Caenorhabditis elegans. ATSE from Sichuan (T1) effectively prolonged lifespan, enhanced stress resistance, increased SOD activity, and decreased ROS levels, primarily through the FOXO/DAF-16 signaling pathway. Spectrum-effect analysis identified (25S)-officinalisnin-II as the most active compound.
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress.
The study evaluated the antidepressant properties of Asparagus cochinchinensis extract in a rat model of menopausal depression induced by ovariectomy and chronic unpredictable mild stress. The extract ameliorated depression-like behavior and modulated the BDNF-TrkB pathway.
Furostanol oligoglycosides from Asparagus cochinchinensis.
The paper reports the isolation and structural elucidation of three new furostanol oligoglycosides, aspacochioside A, B, and C, from the roots of Asparagus cochinchinensis, using spectroscopic and chemical methods.
Furostanol Saponins from Asparagus cochinchinensis and Their Cytotoxicity.
Phytochemical investigation of Asparagus cochinchinensis roots led to the isolation of a new furostanol saponin and three known congeners. The saponins were evaluated for cytotoxic effects on human liver and lung adenocarcinoma cancer cells in vitro, with two showing significant cytotoxicity and inhibition of cell proliferation.
Comparison of biofunctional activity of Asparagus cochinchinensis (Lour.) Merr. Extract before and after fermentation with Aspergillus oryzae.
The study compared the biofunctional activity of Asparagus cochinchinensis root extract before and after fermentation with Aspergillus oryzae. The fermented extract showed enhanced antioxidant and antityrosinase activity, with lower melanin production in human melanoma cells compared to the unfermented extract. The fermented extract may be useful for developing health food or cosmetic ingredients.
Asparagus cochinchinensis stimulates release of nerve growth factor and abrogates oxidative stress in the Tg2576 model for Alzheimer's disease.
The study investigated the effects of aqueous extract of Asparagus cochinchinensis root (AEAC) on Tg2576 mice, a model for Alzheimer's disease. AEAC treatment enhanced nerve growth factor secretion, reduced oxidative stress, and improved neuronal cell function, suggesting potential therapeutic benefits in Alzheimer's disease.
Aqueous root extract of Asparagus cochinchinensis (Lour.) Merr. Has antioxidant activity in D-galactose-induced aging mice.
The study explored the antioxidant capacity of the aqueous root extract of Asparagus cochinchinensis in D-galactose-induced aging mice. The extract showed strong antioxidant activity, similar to vitamin C, and enhanced SOD, CAT, and NOS activities, increased NO content, and reduced MDA content in aging mice.
Ethyl acetate extract from Asparagus cochinchinensis exerts anti‑inflammatory effects in LPS‑stimulated RAW264.7 macrophage cells by regulating COX‑2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity.
The study investigates the anti-inflammatory effects of ethyl acetate extract from Asparagus cochinchinensis root in LPS-stimulated RAW264.7 macrophage cells. The extract reduced nitric oxide production, COX-2 expression, and ROS levels, and differentially regulated inflammatory cytokines and cell cycle, suggesting its potential as a treatment for inflammatory diseases.
Saponin-enriched extract of Asparagus cochinchinensis alleviates airway inflammation and remodeling in ovalbumin-induced asthma model.
The study examined the effects of a saponin-enriched extract of Asparagus cochinchinensis (SEAC) on airway inflammation and remodeling in an ovalbumin-induced asthma model. SEAC treatment reduced nitric oxide levels, immune cell infiltration, and inflammatory cytokine levels, indicating its potential as an anti-inflammatory agent for asthma.
The antioxidant effect of Asparagus cochinchinensis (Lour.) Merr. shoot in D-galactose induced mice aging model and in vitro.
The study explored the antioxidant effects of the aqueous extract of Asparagus cochinchinensis (Lour.) Merr. shoot in D-galactose induced aging mice and in vitro. The extract showed strong radical scavenging capabilities, increased NOS, CAT, and SOD activities, and improved microstructure of mice viscera, suggesting potential anti-aging benefits.
The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies.
In vitro and in vivo studies on Asparagus cochinchinensis (AC) extract showed neuroprotective and antidepressant-like effects. AC reduced immobility time in the tail suspension test and decreased infarct size after middle cerebral artery occlusion in animals. In vitro, AC saponins inhibited H2O2-induced cell death in cortical neurons, with effects linked to Shp-2, ErK1/2, and Akt signaling pathways.
Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents.
The study used Drosophila as a model to investigate the effect of Asparagus cochinchinensis extracts on gut health following ingestion of metal ions. The extract increased survival rate, decreased epithelial cell death, and attenuated gut morphological changes induced by metal ions.
Therapeutic effect of ethyl acetate extract from Asparagus cochinchinensis on phthalic anhydride-induced skin inflammation.
The study evaluated the suppressive effects of ethyl acetate extracts of Asparagus cochinchinensis (EaEAC) on phthalic anhydride-induced skin inflammation in IL-4/Luc/CNS-1 transgenic mice. EaEAC treatment significantly decreased lymph node weight, IgE concentration, epidermis thickness, and mast cell infiltration, as well as the expression of IL-1β and TNF-α, suggesting its potential to improve skin inflammation.
Anti-neuroinflammatory constituents from Asparagus cochinchinensis.
The study isolated three new pregnane glycosides and four known furostanol glycosides from Asparagus cochinchinensis roots. These compounds were evaluated for anti-neuroinflammatory activity in LPS-induced BV-2 microglial cells, with compounds 2, 3, and 4 showing significant inhibition of NO production.
Effects of root and stem extracts of Asparagus cochinchinensis on biochemical indicators related to aging in the brain and liver of mice.
The study compared the effects of Asparagus cochinchinensis root and stem extracts on aging-related biochemical indicators in mice. Root extracts increased SOD activity and reduced MDA content, slowing aging, while stem extracts had the opposite effect, suggesting they may not be suitable for aging-related treatments.
Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation.
The study investigated the anti-inflammatory effects of Asparagus cochinchinensis extract (ACE) on skin inflammation in mice. ACE inhibited topical edema, reduced skin thickness and tissue weight, decreased inflammatory cytokine production, and reduced vascular permeability in TPA-induced mouse ear edema and acetic acid-induced vascular permeability tests.
Bioactive constituents from Asparagus cochinchinensis.
Bioassay-directed fractionation of Asparagus cochinchinensis roots led to the isolation of new compounds, including asparacoside and asparacosins A and B. Compounds 1, 6, and 8 showed moderate cytotoxicity in various cell lines with IC(50) values between 4 and 12 microg/mL.
Inhibition of tumor necrosis factor-alpha-induced apoptosis by Asparagus cochinchinensis in Hep G2 cells.
In vitro study on Hep G2 cells showing that an aqueous extract of Asparagus cochinchinensis roots inhibited ethanol-induced TNF-alpha secretion and cytotoxicity. The extract also inhibited TNF-alpha-induced apoptosis, suggesting a protective effect against ethanol-induced cytotoxicity.
Oligofurostanosides from Asparagus cochinchinensis.
The study isolated a new oligofurostanoside and two known furostanosides from the aqueous extract of Asparagus cochinchinensis.
Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion from astrocytes.
The study investigated the inhibitory effect of Asparagus cochinchinensis aqueous extract (ACAE) on TNF-alpha secretion from mouse astrocytes. ACAE dose-dependently inhibited TNF-alpha secretion by astrocytes stimulated with substance P and LPS, suggesting anti-inflammatory activity in the central nervous system.