Research
Chamomile
53 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Chamomile: A systematic review of adverse events.
Systematic review of adverse events associated with chamomile in human studies. Out of 72 trials and 11 case reports, 65 adverse events were reported, primarily gastrointestinal complications and drowsiness, which were self-limiting and non-serious. Six case reports noted allergic reactions, including anaphylactic reactions and acute rhinitis.
Comparing the efficacy of topical interventions for pain management in oral lichen planus: a time-stratified bayesian network analysis of randomized controlled trials.
A Bayesian network meta-analysis of 64 randomized trials with 2,839 participants evaluated 24 interventions for oral lichen planus pain management. Corticosteroids and immunosuppressants showed significant efficacy, while topical laser therapy and plant-based agents like Chamomile were effective alternatives for early-to-mid stage symptom management.
Anti-inflammatory effect of chamomile from randomized clinical trials: a systematic review and meta-analyses.
Systematic review and meta-analysis of 11 randomized clinical trials assessing chamomile's efficacy as an anti-inflammatory and antimicrobial agent. Chamomile showed statistically significant reductions in mucositis severity and pain level, indicating its anti-inflammatory effects.
Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of clinical trials investigating chamomile's effects on sleep, including 10 studies with 772 participants. Chamomile significantly reduced PSQI scores and improved the number of awakenings after sleep, but did not improve sleep duration, efficiency, or daytime functioning.
Topical medications for the treatment of recurrent aphthous stomatitis: A network meta-analysis.
Network meta-analysis of 43 RCTs with 3067 participants comparing 20 topical medications for recurrent aphthous stomatitis. No significant differences in pain reduction were found, but doxycycline showed a significant effect in accelerating healing time. Chamomile, among others, was identified as one of the most efficacious treatments at different evaluation times.
Effect of Chamomile on the Complications of Cancer: A Systematic Review.
Systematic review of 18 studies with a total of 1099 cancer patients examining the effects of chamomile on cancer complications. Chamomile effectively reduced oral mucositis, skin complications, depression, and vomiting, and improved appetite and quality of life.
Comparative prevention potential of 10 mouthwashes on intolerable oral mucositis in cancer patients: A Bayesian network analysis.
Meta-analysis of 36 RCTs with 2594 patients comparing the preventive effects of ten mouthwashes on intolerable oral mucositis in cancer patients. Honey, chamomile, curcumin, and benzydamine mouthwashes were found to be superior to placebo, with honey being more efficacious than chlorhexidine, sucralfate, and povidone-iodine.
Efficacy and safety of Matricaria chamomilla intervention in managing menopausal symptoms: a triple-blind clinical trial.
Triple-blind clinical trial with 80 postmenopausal women assessing the efficacy and safety of chamomile (Matricaria chamomilla) in managing menopausal symptoms. The chamomile group showed significant improvements in symptom scores compared to placebo, but some participants experienced side effects such as mouth sores and skin reactions.
Comparison of liposomal gel with and without chamomile to prevent radiation dermatitis in breast cancer patients: a randomized controlled trial.
This double-blind randomized clinical trial compared a liposomal gel with and without chamomile extract for preventing radiation dermatitis in 100 breast cancer patients undergoing radiotherapy. No statistically significant differences were found between the two gels in terms of radiation dermatitis occurrence and dose at first occurrence, although the chamomile group reported fewer symptoms, especially itching, in the first 3 weeks.
Effect of Chamomile and Olive Oils on Volume, Range of Motion, and Quality of Life in Breast Cancer-Related Lymphedema: A Randomized Controlled Trial.
Double-blind RCT with 63 breast cancer survivors with lymphedema comparing standard complete decongestive therapy (CDT) alone, CDT with olive oil, and CDT with chamomile and olive oil. Lymphedema volume and range of motion improved in all groups, but no significant differences were found between groups. Quality of life improvements were not statistically significant.
Prophylactic effect of chamomile on post-dural puncture headache in women undergoing elective cesarean section: A randomized, double blind, placebo-controlled clinical trial.
RCT evaluating the prophylactic effect of topical chamomile ointment on post-dural puncture headache (PDPH) in 148 women undergoing elective cesarean section. Chamomile ointment significantly reduced PDPH incidence compared to placebo at 6 and 12 hours after spinal anesthesia.
Effect of Chamomile Vaginal Gel on the Sexual Function in Postmenopausal Women: A Double-Blind Randomized Controlled Trial.
This double-blind randomized controlled trial investigated the effect of chamomile vaginal gel on sexual function in 96 postmenopausal women with sexual dysfunction. The study found that chamomile vaginal gel significantly improved all six sexual function domains and the total FSFI score compared to placebo. There was no significant difference between chamomile gel and conjugated estrogen cream except in orgasm and sexual satisfaction.
Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis.
RCT comparing isotonic seawater nasal spray containing chamomile liquid extract to other isotonic seawater nasal washing solutions in 123 patients with allergic rhinitis. The chamomile group showed significant improvements in Sino-Nasal Outcome Test-22 scores and nasal mucociliary clearance times compared to other groups.
[Clinical evaluation of Compound Chamomile and Lidocaine Hydrochloride Gel for postoperative hypospadias in children].
RCT evaluating Compound Chamomile and Lidocaine Hydrochloride Gel for postoperative hypospadias in children. The trial group showed significantly lower pain scores and more cases of edema regression compared to the control group.
Medicinal plants used for the treatment of mucositis induced by oncotherapy: a systematic review.
Systematic review identifying effective medicinal plants for treating mucositis induced by oncotherapy. Matricaria chamomilla showed promising results in reducing severity and incidence of lesions with improved pain symptomatology. Other plant extracts also improved lesions.
Chamomile (Matricaria recutita L.) and diabetes mellitus, current knowledge and the way forward: A systematic review.
Systematic review evaluating the effects of chamomile on metabolic risk markers and complications of diabetes mellitus. Chamomile administration showed significant improvements in glycemic control, lipid profiles, and oxidative stress indicators in diabetes mellitus.
[Evidence of dermatological effects of chamomile].
Systematic review exploring the evidence base of the dermatological effects of chamomile. While numerous beneficial effects have been suggested, no studies have significantly substantiated these claims due to design and quality issues.
Effects of chamomile and -theanine beverage on menstrual pain, menstrual symptoms, mood, and sleep quality in young women experiencing primary dysmenorrhea: A randomized, double-blind, placebo-controlled study.
RCT evaluating the effects of chamomile and 1-theanine beverage on menstrual symptoms, pain intensity, mood, and sleep quality in young women with primary dysmenorrhea. The intervention significantly reduced pain and improved mood and sleep quality compared to baseline.
[Compound Chamomile and Lidocaine Hydrochloride Gel applied at different time-windows for premature ejaculation: A prospective single-center randomized controlled study].
RCT investigating the efficacy and safety of Compound Chamomile and Lidocaine Hydrochloride Gel applied at different time-windows for premature ejaculation. Significant improvements in intravaginal ejaculation latency time and PE diagnostic tool scores were observed, with no significant adverse effects.
The effect of topical chamomile in the prevention of chemotherapy-induced oral mucositis: A randomized clinical trial.
A randomized clinical trial assessed the effectiveness of topical chamomile oral gel in preventing chemotherapy-induced oral mucositis in 45 patients. Chamomile gel reduced mucositis severity and pain scores compared to conventional treatment.
Nonpharmacological interventions to improve sleep in nursing home residents: A systematic review.
Systematic review of nonpharmacological interventions to improve sleep in nursing home residents. Chamomile extract intake, among other interventions, demonstrated positive impacts on sleep quality and nighttime sleep.
Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study.
A randomized, double-blind, placebo-controlled crossover study evaluated the effect of topical chamomile oleogel for pain relief in migraine without aura. The study involved 72 patients and found that chamomile oleogel significantly decreased pain, nausea, vomiting, photophobia, and phonophobia after 30 minutes.
Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial.
An open randomized controlled trial comparing the efficacy of a mixture of Matricaria chamomilla, Melissa officinalis, and tyndallized Lactobacillus acidophilus (HA122) with Lactobacillus reuteri DSM 17938 and simethicone in treating infantile colic. The study found that both the mixture and L. reuteri were significantly more effective than simethicone in reducing mean daily crying time in infants with colic.
Effectiveness of Matricaria chamomilla (chamomile) extract on pain control of cyclic mastalgia: a double-blind randomised controlled trial.
This double-blind randomized controlled trial evaluated the effectiveness of chamomile extract on pain control of cyclic mastalgia in 60 patients. Significant pain reduction was observed in the chamomile group compared to placebo after two months, suggesting chamomile as a well-tolerated and effective treatment for mild to moderate mastalgia.
Specific expectancies are associated with symptomatic outcomes and side effect burden in a trial of chamomile extract for generalized anxiety disorder.
This study investigated the role of patient expectancies in the efficacy and side effects of chamomile treatment for Generalized Anxiety Disorder (GAD). Higher efficacy expectancies predicted greater improvement in GAD-7 scores and a higher likelihood of clinical response, while higher side effect expectancies were associated with more reported side effects.
Topical use of Matricaria recutita L (Chamomile) Oil in the Treatment of Monosymptomatic Enuresis in Children: A Double-Blind Randomized Controlled Trial.
Double-blind randomized controlled trial evaluating the efficacy of topical Matricaria recutita L (chamomile) oil in treating monosymptomatic enuresis in children. The intervention group showed a statistically significant reduction in enuresis frequency compared to placebo, with no adverse events reported.
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial.
RCT of 80 Taiwanese postnatal women with poor sleep quality comparing chamomile tea consumption to regular postpartum care over 2 weeks. The chamomile group showed significantly improved sleep quality and reduced depression symptoms compared to control, though effects were not sustained at 4-week follow-up.
Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus.
This single-blind randomized controlled trial studied the effects of chamomile tea on glycemic control and antioxidant status in 64 subjects with type 2 diabetes mellitus. Chamomile tea significantly decreased glycosylated hemoglobin, serum insulin levels, and insulin resistance, while increasing antioxidant enzyme activities compared to the control group.
Effect of a 2% topical chamomile application for treating burning mouth syndrome: a controlled clinical trial.
A prospective randomized placebo-controlled double-blind study evaluated the efficacy of 2% chamomile gel for treating burning mouth syndrome in 62 patients. Both chamomile and placebo groups showed significant improvements in pain, xerostomia, and quality of life, but no significant differences were found between the groups, questioning the efficacy of chamomile gel.
Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial.
RCT assessing the efficacy and safety of topical chamomile oil in patients with knee osteoarthritis. Chamomile oil significantly reduced the need for acetaminophen compared to diclofenac and placebo, though no significant differences were found in WOMAC questionnaire domains. No adverse events were reported.
Effectiveness of chamomile tea on glycemic control and serum lipid profile in patients with type 2 diabetes.
Single-blind RCT of 64 individuals with type 2 diabetes mellitus assessing chamomile tea consumption on glycemic control and serum lipid profile. Chamomile tea significantly decreased HbA1C, serum insulin levels, insulin resistance, total cholesterol, triglycerides, and LDL cholesterol compared to control.
Comparison of the effects of Matricaria chamomila (Chamomile) extract and mefenamic acid on the intensity of premenstrual syndrome.
This clinical randomized double-blind trial compared the effects of Chamomile Extract and Mefenamic acid on the intensity of premenstrual syndrome symptoms in 90 students. Chamomile Extract significantly reduced the intensity of emotional symptoms compared to Mefenamic acid, while the reduction of physical symptoms was not significantly different between the groups.
Comparison of the antibacterial effects of matrica & Persica™ and chlorhexidine gluconate mouthwashes in mechanically ventilated ICU patients: a double blind randomized clinical trial.
Double blind randomized clinical trial comparing antibacterial effects of chlorhexidine gluconate, Matrica (chamomile extracts), Persica, and normal saline in 80 ICU patients. All mouthwashes, including herbal ones, significantly reduced bacterial colonies of S. aureus and S. pneumoniae.
Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study.
This exploratory study analyzed data from a 2009 randomized, double-blind, placebo-controlled trial to assess the antidepressant activity of chamomile extract in participants with anxiety and depression. The study found a significantly greater reduction in Hamilton Depression Rating scores for chamomile compared to placebo, suggesting potential antidepressant effects.
Using chamomile solution or a 1% topical hydrocortisone ointment in the management of peristomal skin lesions in colostomy patients: results of a controlled clinical study.
Prospective study comparing German chamomile solution to 1% hydrocortisone ointment for peristomal skin lesions in colostomy patients. Chamomile treatment resulted in faster healing and symptom resolution compared to hydrocortisone, suggesting its potential as an alternative to corticosteroids.
A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder.
A randomized, double-blind, placebo-controlled trial of chamomile extract in 57 patients with mild to moderate generalized anxiety disorder. Chamomile showed a significantly greater reduction in mean total HAM-A score compared to placebo, suggesting modest anxiolytic activity.
Effectiveness of lubrication of endotracheal tube cuff with chamomile-extract for prevention of postoperative sore throat and hoarseness.
RCT assessing the efficacy of chamomile extract lubrication on endotracheal tube cuffs to prevent postoperative sore throat and hoarseness in 161 surgical patients. No statistically significant difference was found between the chamomile and control groups in preventing sore throat or hoarseness.
Proof of efficacy of Kamillosan(R) cream in atopic eczema.
Partially double-blind, randomized study comparing Kamillosan(R) cream containing chamomile extract to 0.5% hydrocortisone cream and placebo in patients with medium-degree atopic eczema. Kamillosan(R) cream showed mild superiority over hydrocortisone and marginal difference compared to placebo after 2 weeks.
The Mechanism Action of German Chamomile (Matricaria recutita L.) in the Treatment of Eczema: Based on Dose–Effect Weight Coefficient Network Pharmacology
The study investigates the active ingredients in German chamomile volatile oil and its mechanism of action in treating eczema. It uses a new network pharmacology method to show that German chamomile volatile oil inhibits the Th17 cell differentiation signaling pathway, reducing inflammation by decreasing pro-inflammatory factors.
Safety of a formulation containing chitosan microparticles with chamomile: blind controlled clinical trial.
Phase I blind, controlled, non-randomized clinical trial evaluating the safety of a topical formulation containing chamomile microparticles coated with chitosan in 35 healthy participants. The formulation improved skin hydration without causing irritation, though it increased transepidermal water loss.
An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder.
Open-label clinical trial of chamomile in 45 subjects with generalized anxiety disorder (GAD) assessing salivary cortisol changes. Symptom improvement was significantly associated with increases in morning salivary cortisol and a greater decrease in cortisol from morning to the rest of the day.
Efficacy of topical chamomile on the incidence of phlebitis due to an amiodarone infusion in coronary care patients: a double-blind, randomized controlled trial.
This double-blind, randomized controlled trial evaluated the effect of topical chamomile on the incidence of phlebitis in 40 coronary care patients receiving amiodarone infusion. The intervention group using chamomile ointment showed a significantly lower and later incidence of phlebitis compared to the control group using a placebo.
Gel of chamomile vs. urea cream to prevent acute radiation dermatitis in patients with head and neck cancer: a randomized controlled trial.
RCT comparing a gel made with chamomile to a cream of urea for preventing radiation dermatitis in 48 patients with head and neck cancer undergoing radiotherapy. The study aims to delay the occurrence of radiation dermatitis.
Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study.
Randomized pilot study comparing cryotherapy with chamomile infusion to water-only cryotherapy for preventing oral mucositis in cancer patients receiving chemotherapy. The chamomile group had lower occurrence of oral mucositis, less mouth pain, and no ulcerations compared to the control group.
Clinical efficacy of a 1% Matricaria chamomile L. mouthwash and 0.12% chlorhexidine for gingivitis control in patients undergoing orthodontic treatment with fixed appliances.
This pilot study evaluated the efficacy of a 1% Matricaria chamomilla L. mouthwash in reducing gingival inflammation and plaque formation in patients with fixed orthodontic appliances. The study found that the MTC mouthwash significantly decreased visible plaque index and gingival bleeding index compared to placebo, suggesting antimicrobial and anti-inflammatory benefits.
An in vivo study examining the antiinflammatory effects of chamomile, meadowsweet, and willow bark in a novel functional beverage.
RCT of a herbal beverage containing chamomile, meadowsweet, and willow bark tested for antiinflammatory effects in 20 healthy adults over 4 weeks. The treatment group showed improvements in joint function and pain, but no significant antiinflammatory effects were observed.
Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study.
Randomized, double-blind, placebo-controlled pilot trial of 270 mg chamomile twice daily in 34 patients with chronic primary insomnia. No significant differences in sleep diary measures between groups, but chamomile showed modest advantage on daytime functioning. Effect sizes were small to moderate, with mixed benefits on sleep measures.
An evaluation of aromatherapy massage in palliative care.
RCT of 103 cancer patients in palliative care comparing massage with carrier oil to massage with Roman chamomile essential oil. The aromatherapy group showed significant reductions in anxiety and improvements in psychological and quality of life scores.
Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis.
Phase III, double-blind, placebo-controlled trial testing chamomile mouthwash for prevention of 5-FU-induced oral mucositis in 164 patients. No significant difference in stomatitis scores between chamomile and placebo groups. No toxicity observed.
Estimation of the Controlled Release of Antioxidants from β-Cyclodextrin/Chamomile (Matricaria chamomilla L.) or Milk Thistle (Silybum marianum L.), Asteraceae, Hydrophilic Extract Complexes through the Fast and Cheap Spectrophotometric Technique
The study models the controlled release of antioxidants from β-cyclodextrin complexes with chamomile and milk thistle extracts using a spectrophotometric method. It evaluates the release mechanisms and transdermal pharmaceutical formulations, revealing non-Fickian diffusion for antioxidant release in most formulations.
Fabrication of bioinspired keratin/sodium alginate based biopolymeric mat loaded with herbal drug and green synthesized zinc oxide nanoparticles as a dual drug antimicrobial wound dressing.
The study focuses on fabricating keratin-sodium alginate based wound dressings loaded with green synthesized zinc oxide nanoparticles and chamomile herbal drug. The biopolymeric mat exhibits strong antibacterial effects, enhanced biocompatibility, and increased collagen deposition, promoting wound healing.
Enzyme-assisted modification of flavonoids from Matricaria chamomilla: antioxidant activity and inhibitory effect on digestive enzymes
The study investigates the enzymatic modification of flavonoids in Matricaria chamomilla using hesperidinase and β-galactosidase, enhancing its antioxidant activity and inhibitory effect on pancreatic lipase. The enzymatically treated infusion showed a greater inhibitory effect on pancreatic lipase compared to the unmodified infusion, suggesting potential health benefits.
An integrative approach to eczema (atopic dermatitis).
The article discusses an integrative treatment protocol for eczema using natural therapies, highlighting a patented chamomile preparation shown to be as effective as hydrocortisone in relieving symptoms of itching and inflammation without the side effects of corticosteroids.