Research
Ceramides (Oral)
9 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Attenuation of Atopic Dermatitis in Newborns, Infants, and Children With Prescription Treatment and Ceramide-Containing Skin Care: A Systematic Literature Review and Consensus.
Systematic literature review and consensus by pediatric dermatologists on the use of ceramide-containing moisturizers for atopic dermatitis in infants and children. Daily use of such moisturizers reduces the rate of AD flares and the need for topical steroid treatment, potentially delaying AD occurrence and mitigating severity.
A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial.
A randomized trial evaluated a ceramide-dominant moisturizing cream and cleanser in adults with moderate eczema over 28 days. The active group showed significant improvements in transepidermal water loss and skin hydration compared to placebo, although eczema severity scores decreased in both groups. Patient satisfaction was higher in the active group for itch relief and skin softness.
The Effect of a Ceramide-Containing Product on Stratum Corneum Lipid Levels in Dry Legs.
RCT evaluating a ceramide-containing moisturizing cream in female subjects with dry, itchy skin. The cream increased skin hydration and reduced visible signs of dry skin, with significant increases in ceramide, cholesterol, and free fatty acid levels in the stratum corneum after 4 weeks.
Safety and Efficacy of Oral Intake of Ceramide-Containing Acetic Acid Bacteria for Improving the Stratum Corneum Hydration: A Randomized, Double-Blind, Placebo-Controlled Study over 12 Weeks.
RCT investigating the effects of oral intake of ceramide-containing acetic acid bacteria on skin moisture content in adults with dry skin. Over 12 weeks, ceramide intake significantly improved stratum corneum hydration without harmful effects.
A Split-Face Micro-Needling Study to Evaluate the Efficacy and Consumer Perception of a Novel Moisturization Agent.
A randomized, double-blind, split-face trial with 30 participants evaluated the efficacy of Aestura ATOBARRIER 365 Cream containing ceramides in promoting skin barrier recovery after microneedling. The active formulation showed significant reductions in transepidermal water loss and erythema, with high participant satisfaction in skin hydration and reduced irritation.
Efficacy and Safety of Oral Administration of Wine Lees Extract (WLE)-Derived Ceramides and Glucosylceramides in Enhancing Skin Barrier Function: A Randomized, Double-Blind, Placebo-Controlled Study.
A randomized, double-blind, placebo-controlled study with 30 healthy Japanese subjects evaluated the efficacy and safety of wine lees extract-derived ceramides and glucosylceramides in enhancing skin barrier function. The test group showed significantly lower transepidermal water loss compared to placebo after 12 weeks, indicating improved skin barrier function.
The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment.
A split site, double-blinded, randomized, controlled study in 24 senile subjects with mild to moderate xerosis compared the efficacy of ceramide-containing moisturizer to hydrophilic cream. The ceramide moisturizer improved skin hydration, barrier function, and skin pH significantly over 24 hours, 28 days, and 7 days post-application, with additional benefits in hemoglobin index, wrinkle, and texture.
Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile.
RCT of 39 female subjects with sensitive skin comparing ceramide complex cream to placebo cream over 4 weeks. The ceramide complex cream significantly ameliorated lactic acid sensations and improved skin barrier function, as indicated by increased ceramide content and changes in TEWL and conductance values.
Cohort Using a Ceramides Containing Cleanser and Cream With Salicylic Acid for Dry, Flaking, and Scaling Skin Conditions.
Cohort study of 35 adults with mild-to-moderate dry skin conditions using a ceramide-containing cleanser and cream with salicylic acid. Significant improvement in skin condition was observed after 28 days, with enhanced quality of life and high safety and tolerability reported.