Research
Capsaicin
119 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effect of red pepper/capsaicin on cardiovascular risk factors: a systematic review, meta-analysis, and GRADE assessment.
This systematic review and meta-analysis evaluated the effect of red pepper/capsaicin supplementation on cardiovascular risk factors across 13 RCTs with 821 participants. The supplementation was associated with small, statistically unstable reductions in total cholesterol and diastolic blood pressure, but no significant effects on other cardiovascular risk factors. The findings were marked by substantial heterogeneity and low certainty of evidence.
Systematic Review of Topical Capsaicin 0.075% for the Treatment of Neuropathic Pain: Efficacy, Safety, and Tolerability.
Systematic review of 22 studies evaluating topical capsaicin 0.075% for neuropathic pain. Capsaicin showed significant efficacy in reducing pain intensity and improving quality of life, with tolerable localized adverse effects. The 0.075% formulation was more effective than lower concentrations.
Refining capsaicin-induced pain models: A comprehensive analysis of preclinical practices and their translational potential.
This systematic review investigates the use of capsaicin as a nociceptive stimulus in preclinical behavioural models of pain. It examines the purpose of capsaicin use, species and sexes of animals tested, methods of administration, dosage, and types of pain behaviours assessed. The review highlights the dominance of male rodent studies and the lack of novel behavioural techniques, suggesting lower doses of capsaicin should be considered.
The effect of capsaicin, capsinoids, and pepper-based interventions on lipid profiles in overweight or obese individuals: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis assessed the impact of capsaicin, capsinoids, and pepper-derived products on lipid profiles in overweight or obese individuals. The meta-analysis of 12 RCTs showed significant reductions in triglycerides and total cholesterol, especially with higher doses and longer intervention periods.
Infiltrative Treatment of Morton's Neuroma: A Systematic Review.
Systematic review evaluating the efficacy of infiltrative treatments for Morton's neuroma, including capsaicin, corticosteroids, sclerosant injections, and hyaluronic acid. Capsaicin showed a VAS score reduction of 51.8%, and corticosteroids were highly effective. Alcohol and hyaluronic acid injections are well tolerated but require further research.
Efficacy and safety of topical capsaicin in the treatment of osteoarthritis pain: A systematic review and meta-analysis.
Systematic review and meta-analysis of eight RCTs involving 498 patients evaluating the efficacy and safety of topical capsaicin for osteoarthritis pain. Topical capsaicin may reduce pain severity compared to placebo but may increase burning sensation at the application site. Limitations include short study durations and small sample sizes.
SAEM GRACE: Dopamine antagonists and topical capsaicin for cannabis hyperemesis syndrome in the emergency department: A systematic review of direct evidence.
Systematic review evaluating the effectiveness of capsaicin and dopamine antagonists in managing cannabis hyperemesis syndrome (CHS) in the emergency department. Mixed evidence was found for capsaicin's efficacy in reducing nausea and emesis, while dopamine antagonists showed potential benefits. The review highlights the need for more rigorous trials due to limited direct evidence and methodological concerns.
Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of capsaicin for treating non-allergic rhinitis (NAR). Nine placebo-controlled studies were included, showing significant improvements in total nasal symptom scores and visual analog scale scores, with a higher proportion of therapeutic responders in the capsaicin group. The analysis suggests capsaicin may alleviate NAR symptoms, but further research is needed due to study limitations.
The efficacy of topical 8% capsaicin patches for the treatment of postsurgical neuropathic pain: a systematic review.
Systematic review investigating the efficacy of topical 8% capsaicin patches for reducing postsurgical neuropathic pain. A random-effects pooled-analysis showed a significant effect size with a Cohen's d of 1.09, indicating a decrease in pain level and area.
Genetic Influence on Capsaicin Tolerance: Precision Nutrition Implications for Obesity Handling.
Systematic review analyzing the role of genetic polymorphisms in capsaicin tolerance and its implications for obesity management. The review identified 28 single nucleotide polymorphisms associated with capsaicin tolerance traits, suggesting potential for nutrigenetic strategies in obesity treatment.
The effects of capsaicin intake on weight loss among overweight and obese subjects: a systematic review and meta-analysis of randomised controlled trials.
This systematic review and meta-analysis evaluated the effect of capsaicin on weight loss in adults, including 15 RCTs with 762 individuals. Capsaicin supplementation resulted in significant reductions in BMI, body weight, and waist circumference compared to control, suggesting modest effects on weight management for overweight or obese individuals.
A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease.
Systematic review of 11 studies on capsaicin's effects on Alzheimer's Disease (AD) in rodents and cell cultures. Capsaicin attenuated tau deposition, apoptosis, and synaptic dysfunction, with mixed effects on amyloid processing. It improved spatial and working memory, learning, and emotional behaviors in rodents, showing promise for AD treatment.
Topical capsaicin for the management of painful diabetic neuropathy: a narrative systematic review.
Narrative systematic review of topical capsaicin formulations for diabetic peripheral neuropathy. 8% capsaicin patches significantly reduced symptoms and improved sleep quality. Capsaicin cream reduced pain at weeks two and six, but not at week eight. 0.075% capsaicin gel was effective, while 0.025% was not. Capsaicin cream was not superior to clonidine gel. Common adverse events included application site discomfort, erythema, and burning.
Effects of Capsaicin and Capsiate on Endurance Performance: A Meta-Analysis.
This meta-analysis examined the effects of capsaicin and capsiate on endurance performance in humans. Fourteen studies were included, showing that capsaicin/capsiate supplementation enhances muscular endurance but has unclear effects on aerobic endurance. Capsaicin/capsiate also reduced the rating of perceived exertion following muscular endurance tests.
Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer.
Systematic review of global research on capsaicin from 2001 to 2021, focusing on its anti-cancer properties and mechanisms. The review highlights capsaicin's chemo-preventive effects and its potential therapeutic significance in cancer treatment, despite limited clinical studies.
Spicy Food and Chili Peppers and Multiple Health Outcomes: Umbrella Review.
Umbrella review of 11 systematic reviews and meta-analyses assessing the health effects of spicy food and chili peppers, focusing on capsaicin. The review finds unclear health effects, with direct correlations to esophageal, gastric, and gallbladder cancers, and negative connections to metabolism, mortality, and cardiovascular disease. A nonlinear relationship between gastric cancer risk and capsaicin intake is noted.
The therapeutic effect of capsaicin on oropharyngeal dysphagia: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the therapeutic effect of capsaicin on swallowing disorders in stroke patients and the elderly. The meta-analysis included five high-quality randomized controlled trials and showed significant improvement in swallowing function in the capsaicin group compared to the control group.
Topical capsaicin for the treatment of cannabinoid hyperemesis syndrome, a systematic review and meta-analysis.
Systematic review and meta-analysis of 7 studies evaluating topical capsaicin for treating cannabinoid hyperemesis syndrome (CHS). The analysis included 106 patients and assessed variables such as time to symptom relief and ED length of stay. Capsaicin appears to be an effective treatment option for CHS, with further randomized controlled trials recommended.
Capsaicin intake and oral carcinogenesis: A systematic review.
Systematic review exploring the relationship between capsaicin intake and the incidence of oral squamous cell carcinoma. The review found that capsaicin acts as a chemopreventive agent, preventing the development of oral cancer through inhibition of malignant cell proliferation and increased apoptosis.
Topical Capsaicin for the Treatment of Neuropathic Pain.
Systematic review of 108 articles on the use of topical capsaicin for neuropathic pain treatment. Capsaicin is effective in improving neuropathic pain without affecting motor and large nerve fibers, with a sensible safety profile.
The effect of red pepper/capsaicin on blood pressure and heart rate: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of clinical trials evaluating the effect of red pepper/capsaicin on blood pressure and heart rate. Meta-analysis showed no significant effect on systolic or diastolic blood pressure and heart rate. High between-study heterogeneity was noted.
High-Dose 8% Capsaicin Patch in Treatment of Chemotherapy-Induced Peripheral Neuropathy. A Systematic Review.
Systematic review of studies on the efficacy and tolerability of topically applied high-concentration (8%) capsaicin in chemotherapy-induced peripheral neuropathy. Capsaicin 8% patch provides significant pain relief, but the small number of studies and patients requires caution.
Pharmacologic and Non-Pharmacologic Interventions for HIV-Neuropathy Pain. A Systematic Review and a Meta-Analysis.
Systematic review and meta-analysis evaluating pharmacologic and non-pharmacologic treatments for HIV neuropathy pain. Capsaicin 8% and smoked cannabis showed efficacy over placebo, though with low methodological quality. Acupuncture/Moxibustion showed marginal benefit among non-pharmacologic modalities.
The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: a network meta-analysis of randomised controlled trials.
Network meta-analysis comparing the efficacy of topical NSAIDs and capsaicin for pain relief in osteoarthritis. Topical NSAIDs were statistically superior to placebo, while capsaicin was only superior at licensed doses. No significant differences were observed between NSAIDs and capsaicin.
Topical capsaicin (high concentration) for chronic neuropathic pain in adults.
Systematic review of high-concentration topical capsaicin for chronic neuropathic pain in adults, including postherpetic neuralgia, HIV-neuropathy, and diabetic neuropathy. The review found that capsaicin provided moderate or substantial pain relief compared to control, though the quality of evidence was moderate to very low. Adverse events were common but not more serious than control.
Capsaicin for non-allergic rhinitis.
Systematic review of four studies involving 302 participants with idiopathic non-allergic rhinitis, comparing intranasal capsaicin to placebo and other treatments. Capsaicin showed improvement in overall nasal symptoms compared to placebo and budesonide, but evidence quality was low to moderate. Further well-conducted RCTs are needed.
The impact of capsaicin intake on risk of developing gastric cancers: a meta-analysis.
Meta-analysis of 10 articles with 2,452 cases and 3,996 controls examining capsaicin intake and gastric cancer risk. Low capsaicin intake showed protective effects, while high intake increased susceptibility to gastric cancer. Results varied by population and H. pylori status.
Qutenza (capsaicin) 8% patch onset and duration of response and effects of multiple treatments in neuropathic pain patients.
Meta-analysis of Qutenza (capsaicin) 8% patch studies in neuropathic pain patients, including those with postherpetic neuralgia and HIV-associated neuropathy. The analysis found that 44% of PHN and 41% of HIV-AN patients had a 30% response, with analgesia starting within a few days and lasting on average 5 months.
Topical capsaicin (high concentration) for chronic neuropathic pain in adults.
Meta-analysis of six studies involving 2073 participants assessing high-concentration (8%) topical capsaicin for chronic neuropathic pain. High-concentration capsaicin showed significant pain relief compared to low-concentration control, with improvements in sleep, fatigue, depression, and quality of life. Local adverse events were common, but serious adverse events were not more frequent than control.
NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia.
Meta-analysis of four controlled studies evaluating the effect of NGX-4010, a capsaicin 8% patch, on postherpetic neuralgia pain. The study found that a single 60-minute treatment with NGX-4010 reduces pain for up to 12 weeks, regardless of concomitant systemic neuropathic pain medication use. Transient application site reactions were the most common adverse events.
Topical capsaicin for chronic neuropathic pain in adults.
Meta-analysis of controlled trials assessing the efficacy and tolerability of topical capsaicin for chronic neuropathic pain in adults. Low dose (0.075%) cream and high dose (8%) patch applications were compared to placebo, showing some pain relief with common local skin reactions. Estimates of benefit and harm are limited by data variability.
Systematic review of topical capsaicin for the treatment of chronic pain.
Systematic review and meta-analysis of randomized controlled trials assessing the efficacy and safety of topically applied capsaicin for chronic pain from neuropathic or musculoskeletal disorders. The analysis included six trials for neuropathic conditions and three for musculoskeletal conditions, showing moderate to poor efficacy but potential usefulness as an adjunct or sole therapy for some patients.
Effect of Capsaicin (8%) Topical System on Sensory Function in Patients With Diabetic Peripheral Neuropathy: Analysis of the PACE Study.
The study analyzed the effects of high-concentration capsaicin topical system (HCCTS) on sensory function in patients with diabetic peripheral neuropathy over 12 months. Repeated HCCTS treatments improved peripheral sensory function, with significant improvements in sensory scores compared to standard care alone.
Randomized Placebo-Controlled Trial of Topical Capsaicin for Delayed Chemotherapy-Induced Nausea and Vomiting.
RCT of 150 patients on highly emetogenic chemotherapy regimens comparing topical capsaicin ointment to placebo for delayed chemotherapy-induced nausea and vomiting. Capsaicin reduced the incidence of nausea and the average number of vomiting episodes during delayed and extended phases without increasing adverse effects.
Effect of Cooling Capsaicin Application Site on Reducing Burning Sensation in Neuropathic Pain Patients: A Randomized Controlled Trial.
RCT evaluating the efficacy of cryotherapy to reduce burning pain induced by capsaicin (8%) patches in neuropathic pain patients. Cooling at the application site significantly reduced burning pain VAS scores at 60 minutes, but had no effect on neuropathic pain over an 8-week follow-up.
How side effects can improve treatment efficacy: a randomized trial.
This randomized trial investigated the role of side effects in enhancing treatment outcomes. 77 healthy participants were made to believe they received fentanyl nasal sprays, but the sprays contained either capsaicin or saline. Results showed that nasal sprays with capsaicin-induced side effects led to lower pain than inert sprays, influenced by individual beliefs and expectations. Functional MRI data indicated involvement of the descending pain modulatory system.
Effect of Capsaicin Atomization on Cough and Swallowing Function in Patients With Hemorrhagic Stroke: A Randomized Controlled Trial.
RCT of 53 patients with hemorrhagic stroke comparing capsaicin nebulization to routine care. Capsaicin nebulization enhanced the number of coughs, reduced postswallow residue, increased substance P levels, and positively affected pulmonary inflammation.
A New Therapeutic Approach for Dystussia and Atussia in Neurogenic Dysphagia: Effect of Aerosolized Capsaicin on Peak Cough Flow.
Controlled intervention study assessing the effect of aerosolized capsaicin on peak cough flow in patients with neurogenic dysphagia. Capsaicin increased tracheobronchial clearance efficacy in patients with dystussia and atussia, enabling access to cough potential impaired by neurological disorder.
Interest of a standardized hypnotic message for the reduction of pain and anxiety in cancer patients treated by capsaicin patch for neuropathic pain: a randomized controlled trial.
RCT evaluating the impact of a standardized hypnosis recording on pain and anxiety in cancer patients treated with a capsaicin patch for neuropathic pain. No significant difference in pain scores was found between groups, but anxiety was significantly lower in the hypnosis group compared to standard application.
Effect of Capsaicin Atomization-Induced Cough on Sputum Excretion in Tracheotomized Patients After Hemorrhagic Stroke: A Randomized Controlled Trial.
RCT investigating the effectiveness of capsaicin nebulization to stimulate cough and promote clearance of respiratory secretions in tracheotomized patients after hemorrhagic stroke. The capsaicin group showed significantly higher daily sputum output and lower CPIS scores compared to the control group, with no significant changes in vital signs during nebulization.
Human surrogate models of central sensitization: A critical review and practical guide.
Systematic review and meta-analysis of human pain models inducing central sensitization and hyperalgesia. Capsaicin and other models reliably induced secondary hyperalgesia, with varying success in inducing dynamic mechanical allodynia. These models may inform drug development by mimicking pathological pain in humans.
Comparison of topical capsaicin and topical piroxicam in the treatment of acute trauma-induced pain: A randomized double-blind trial.
This randomized double-blind trial compared the analgesic efficacy of topical capsaicin and topical piroxicam in 136 patients with acute musculoskeletal injuries. The capsaicin group showed a significantly higher reduction in VAS scores at all measurement times, with the greatest difference observed at the 72nd hour. No significant differences in side effects were noted between the groups.
Capsaicin combined with ice stimulation improves swallowing function in patients with dysphagia after stroke: A randomised controlled trial.
RCT evaluating the effects of capsaicin combined with ice stimulation on swallowing function in patients with dysphagia after stroke. The experimental group showed significantly improved SSA scores and WST levels compared to the control group, indicating enhanced recovery of swallowing function.
Quantitative response of healthy muscle following the induction of capsaicin: an exploratory randomized controlled trial.
This exploratory randomized controlled trial investigates the effects of capsaicin on healthy muscle to determine if it induces regional changes in image texture variables and motor unit activity, potentially supporting the hypothesis of central sensitization in the development of myofascial trigger points.
The Treatment of Topical Drugs for Postherpetic Neuralgia: A Network Meta-Analysis.
Network meta-analysis comparing the efficacy and safety of topical drugs for postherpetic neuralgia (PHN). Lidocaine, high-concentration capsaicin, and aspirin/diethyl ether (ADE) were more effective than placebo, with lidocaine being the most effective and safest option.
Capsaicin 8% Patch Versus Oral Neuropathic Pain Medications for the Treatment of Painful Diabetic Peripheral Neuropathy: A Systematic Literature Review and Network Meta-analysis.
A network meta-analysis compared the efficacy and tolerability of the capsaicin 8% patch with oral neuropathic pain medications in patients with painful diabetic peripheral neuropathy. The capsaicin patch was found to be as effective as oral agents like pregabalin, duloxetine, and gabapentin, with better systemic tolerability.
Intravesical vanilloids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: A systematic review and meta-analysis. A report from the Neuro-Urology Promotion Committee of the International Continence Society (ICS).
Systematic review and meta-analysis assessing the efficacy and safety of intravesical vanilloids, specifically capsaicin, for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis. Pooled data from RCTs showed a reduction in incontinence episodes and voids per 24 hours, but no significant effect on maximum cystometric capacity and storage detrusor pressure. Adverse events were common, and the overall quality of evidence was low.
Capsaicin and capsiate could be appropriate agents for treatment of obesity: A meta-analysis of human studies.
Meta-analysis of human studies on capsaicin and capsinoids effects on energy expenditure and fat oxidation. Results show increased energy expenditure and decreased respiratory quotient, indicating increased fat oxidation, particularly in participants with BMI over 25.
Capsaicin 8% Patch in Painful Diabetic Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Study.
This 12-week RCT evaluated the efficacy and safety of capsaicin 8% patch versus placebo in 369 patients with painful diabetic peripheral neuropathy. Capsaicin treatment provided modest pain relief and sleep quality improvements compared to placebo, with no systemic side effects or sensory deterioration.
Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data.
This systematic review and meta-analysis investigated the effects of capsaicinoids on energy intake. Analysis of 10 clinical trials with 191 participants showed that capsaicinoid ingestion prior to a meal reduced ad libitum energy intake by 309.9kJ (74.0kcal). The findings suggest that capsaicinoids may support weight management through reduced energy intake, although heterogeneity was high.
Neuromodulators for pain management in rheumatoid arthritis.
Meta-analysis of neuromodulators for pain management in rheumatoid arthritis, including oral nefopam, topical capsaicin, and oromucosal cannabis. Capsaicin showed a significant reduction in pain compared to placebo, but all substances had notable side effect profiles.
The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans.
This paper critically reviews and conducts meta-analyses on the effects of capsaicin and capsiate on energy balance in humans. Both compounds are found to augment energy expenditure and enhance fat oxidation, with small effects on suppressing orexigenic sensations, suggesting potential modest benefits for weight management.
A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia.
This multicenter, double-blind, controlled study randomized 299 PHN patients to receive either NGX-4010, a high-concentration capsaicin patch, or a low-concentration control patch for 30, 60, or 90 minutes. The NGX-4010 group showed significantly greater reductions in pain scores compared to control, particularly in the 60-minute and 90-minute groups. Most adverse events were mild to moderate and application-site specific.
Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of RCTs evaluating pharmacological treatments for painful HIV-associated sensory neuropathy. Capsaicin 8%, smoked cannabis, and recombinant human nerve growth factor showed greater efficacy than placebo, though rhNGF is unavailable and smoked cannabis is not recommended as routine therapy.
Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy.
This double-blind multicenter RCT studied the effects of a high-concentration capsaicin dermal patch (NGX-4010) on painful HIV-associated distal sensory polyneuropathy. The study involved 307 patients and found that a single application of NGX-4010 resulted in significant pain reduction over 12 weeks compared to controls. Mild-to-moderate local skin reactions were observed.
Capsaicin for allergic rhinitis in adults.
Systematic review assessing the effectiveness of capsaicin for allergic rhinitis in adults. One small trial did not find evidence of a therapeutic effect of intranasal capsaicin in allergic rhinitis, though a small pharmacological effect on clinical histamine dose response was noted. Leukotriene levels in nasal lavage did not increase in the capsaicin group.
Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study.
Randomized, double-blind, placebo-controlled study of 200 patients assessing the analgesic efficacy of topical 3.3% doxepin hydrochloride, 0.025% capsaicin, and their combination in chronic neuropathic pain. All treatments significantly reduced overall pain, with the combination providing more rapid analgesia. Capsaicin reduced sensitivity and shooting pain, while burning pain increased with doxepin and capsaicin.
Intravesical instillation of capsaicin in urology: A review of the literature.
This meta-analysis reviews the intravesical instillation of capsaicin for lower urinary tract disorders, analyzing eight open and two placebo-controlled trials with 200 patients. Capsaicin improved clinical or urodynamic symptoms in 84.3% of patients with neurogenic hyperreflexic bladder, showing greater efficacy than placebo. However, its effectiveness is less clear for other bladder disorders, and side effects are noted during and after instillation.
Capsaicin-induced secondary hyperalgesia differences between the trigeminal and spinal innervation.
This crossover clinical trial compared secondary hyperalgesia and somatosensory threshold changes induced by topical capsaicin between spinal and trigeminal innervation in 40 healthy individuals. Capsaicin cream was applied to the masseter muscle and forearm, showing higher occurrence and larger areas of allodynia and pinprick hyperalgesia in the forearm. Electrical and mechanical pain thresholds indicated a loss of somatosensory function in the masseter but not in the forearm.
Capsaicin's Role in Mitigating Muscle Soreness and Enhancing Futsal Players' Recovery After Exercise-Induced Muscle Damage.
This randomized, double-blind, placebo-controlled crossover study evaluated the efficacy of capsaicin supplementation in reducing delayed-onset muscle soreness (DOMS) and enhancing strength and power in collegiate male futsal players. Capsaicin significantly improved vertical jump height, pressure pain threshold, and reduced thigh circumference compared to baseline, and decreased DOMS scores compared to placebo and baseline.
Limb, sex, but not acute dietary capsaicin, modulate the near-infrared spectroscopy-vascular occlusion test estimate of muscle metabolism.
RCT investigating the effects of acute dietary capsaicin on muscle metabolism using near-infrared spectroscopy-vascular occlusion test in young healthy men and women. The study found significant limb and sex effects on tissue desaturation rates, but capsaicin did not clearly alter oxidative muscle metabolism.
Topical capsaicin modulates the two-point discrimination threshold-Modulation depends on stimulation modality and intensity.
This study investigated the modulation of the two-point discrimination threshold (2PDT) by topical capsaicin in 30 healthy subjects. The 2PDT was tested using mechanical and thermal stimuli at different intensities before and after applying a capsaicin or placebo patch. Capsaicin increased the 2PDT, significantly for innocuous mechanical stimuli, indicating pain sensitization.
Capsaicin for Cerebral Perfusion Augmentation: A Randomized Open-Label Trial.
The paper is a randomized open-label trial studying the effects of capsaicin on cerebral perfusion augmentation. No abstract is available to provide further details.
A pilot randomized control trial of topical capsaicin as adjunctive therapy for nausea and vomiting of pregnancy.
This pilot RCT tested the feasibility of using topical capsaicin as adjunctive therapy for nausea and vomiting in pregnancy. Thirty pregnant individuals were randomized to receive either capsaicin or placebo. The capsaicin group showed a trend toward decreased mean treatment time, but no significant difference in symptom severity was observed. Capsaicin was well tolerated, suggesting further exploration is feasible.
Disrupted Cortical Homeostatic Plasticity Due to Prolonged Capsaicin-induced Pain.
This study investigated the effects of prolonged capsaicin-induced pain on homeostatic plasticity (HP) and cortical excitability (CE) in 24 healthy participants. Capsaicin reduced CE and disrupted homeostatic responses, which were not restored by ice-induced pain relief. The placebo condition showed normal homeostatic responses.
Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial.
This pilot randomized controlled trial investigated the efficacy of cough desensitization treatment (CDT) using aerosolized capsaicin in 21 adults with refractory chronic cough. Results favored CDT over sham treatment, showing greater improvements in the Leicester Cough Questionnaire scores and reductions in cough-reflex sensitivity.
Capsaicin 8% Patch for Spinal Cord Injury Focal Neuropathic Pain, a Randomized Controlled Trial.
Randomized single-blind crossover trial with 11 SCI patients with refractory neuropathic pain comparing capsaicin 8% patch to a control low dose capsaicin 0.025% patch. Capsaicin 8% patch reduced pain by 35% and 29% at weeks 2 and 4, respectively, and improved mobility, but did not improve quality of life scores.
Topical application of isolated menthol and combined menthol-capsaicin creams: Exercise tolerance, thermal perception, pain, attentional focus and thermoregulation in the heat.
RCT examining the effects of topically applied menthol and menthol-capsaicin creams on exercise tolerance, thermal perception, pain, attentional focus, and thermoregulation in the heat. Menthol reduced pain perception and enhanced cooling sensation, but showed no ergogenic effect on exercise performance. Co-application with capsaicin inhibited menthol's positive sensory effects.
Quantification of Dermal Microcirculatory Changes after Topical Administration of Capsaicin: A Randomized Placebo-Controlled Study in 46 Subjects.
RCT assessing dermal microcirculatory changes after topical application of capsaicin in 46 healthy subjects. Significant increases in superficial and deep skin oxygenation, as well as flow and velocity, were observed, establishing a reference for future studies on flap viability and wound perfusion.
Capsaicin May Improve Swallowing Impairment in Patients with Amyotrophic Lateral Sclerosis: A Randomized Controlled Trial.
RCT examining the effect of capsaicin on swallowing dynamics in 29 patients with neurodegenerative diseases. No significant differences were observed overall, but reductions in latency and elevating periods were correlated with baseline durations in ALS patients.
Safety, Pharmacokinetic, and Pharmacodynamic Study of a Sublingual Formula for the Treatment of Vasovagal Syncope.
Phase I study evaluated the tolerability and safety of a gel formulation containing capsaicin, phenylephrine, and caffeine in normal adult volunteers. The study aimed to characterize the pharmacokinetics of the formulation and determine the highest dose of phenylephrine needed to achieve a target increase in systolic blood pressure. The mixture was well tolerated, with a clinically significant increase in blood pressure noted in subjects receiving the highest dose of phenylephrine.
The Potential Role for Impaired Mucosal Integrity in the Generation of Esophageal Pain Using Capsaicin in Humans: An Explorative Study.
Single-blind, saline-controlled, randomized crossover study in 13 asymptomatic volunteers investigating the effect of capsaicin perfusion on mucosal impedance and pain in the esophagus. Capsaicin perfusion resulted in significantly greater pain intensity and impaired recovery of mucosal impedance compared to saline, with pain response associated with decreased mucosal impedance.
Capsaicin and Its Effect on Exercise Performance, Fatigue and Inflammation after Exercise.
RCT with 10 young healthy males evaluating capsaicin's effects on exercise performance and fatigue. Capsaicin did not significantly affect cardiorespiratory responses or time to exhaustion but attenuated the reduction in potentiated twitch, suggesting potential neuromuscular fatigue attenuation.
Attention Bias to Pain Words Comes Early and Cognitive Load Matters: Evidence from an ERP Study on Experimental Pain.
RCT involving 40 healthy adults to study attention bias to pain using capsaicin to induce experimental pain. The study found that attention bias to pain occurs at an early stage and is influenced by cognitive load, with high-load tasks resulting in longer response times and lower accuracies.
Angular gyrus connectivity at alpha and beta oscillations is reduced during tonic pain - Differential effect of eye state.
This crossover study examined the effect of tonic pain on resting state functional connectivity of the angular gyrus under eyes closed and eyes open conditions. Pain was induced using topical capsaicin on the right forearm of 28 healthy participants. Decreased connectivity at alpha-1 and beta oscillations was found during pain compared to baseline during eyes closed only.
Effect of Topical Analgesia on Desensitization Following 8% Topical Capsaicin Application.
RCT with 24 healthy volunteers testing the effect of EMLA cream pretreatment on pain and desensitization from 8% capsaicin application. EMLA reduced capsaicin-induced pain and enhanced superficial blood perfusion, without interfering with capsaicin-induced desensitization. Capsaicin reduced itch intensity and neurogenic flare compared to EMLA alone.
Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials.
N-of-1 trials comparing 5% ibuprofen gel and 0.025% capsaicin cream for painful knee osteoarthritis in 22 participants. Mean pain reduction was 1.2 on ibuprofen and 1.6 on capsaicin, with 59% showing a greater response to one treatment over the other.
Evidence for engagement of the nucleus of the solitary tract in processing intestinal chemonociceptive input irrespective of conscious pain response in healthy humans.
The study used multiecho multiband 7T functional magnetic resonance imaging to investigate neural processing in the brainstem during duodenal infusion of capsaicin versus placebo in 18 healthy female volunteers. Increased brain activation was observed in regions implicated in pain processing, particularly the nucleus of the solitary tract (NTS), irrespective of conscious pain response.
A Pilot Trial of Topical Capsaicin Cream for Treatment of Cannabinoid Hyperemesis Syndrome.
This double-blind, randomized placebo-controlled pilot trial examined the effectiveness of topical capsaicin cream in patients with nausea and vomiting due to suspected cannabinoid hyperemesis syndrome. The study enrolled 30 patients and found that capsaicin cream significantly reduced nausea at 60 minutes compared to placebo, with a higher proportion of patients experiencing complete resolution of nausea.
Effects of capsaicin on swallowing function in stroke patients with dysphagia: A randomized controlled trial.
A randomized, double-blind study on 69 stroke patients with dysphagia, comparing the effects of natural capsaicin supplementation to placebo on swallowing function. The capsaicin group showed significantly greater improvements in swallowing assessments compared to the placebo group, suggesting capsaicin may aid recovery of swallow function in stroke patients.
Efficacy of Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review.
Systematic review of capsaicin efficacy for treating cannabinoid hyperemesis syndrome (CHS). The review included 5 full-text articles and 6 conference abstracts, with case reports and series suggesting benefit, but retrospective cohort studies showing no significant benefit on primary outcomes. Current data is of low methodological quality, but capsaicin is considered a reasonable adjunctive treatment option.
Efficacy and Safety of 0.625% and 1.25% Capsaicin Patch in Peripheral Neuropathic Pain: Multi-Center, Randomized, and Semi-Double Blind Controlled Study.
Early Phase II, multi-center, randomized, semi-double-blind, placebo-controlled trial comparing 0.625% and 1.25% capsaicin patches to 0.075% capsaicin cream and placebo in 60 patients with peripheral neuropathy. The 0.625% capsaicin patch showed significant pain improvement, with minor skin-related adverse effects reported.
Role of capsaicin- and heat-sensitive afferents in stimulation of acupoint-induced pain and analgesia in humans.
The study investigated the role of capsaicin-sensitive afferents in pain perception and modulation at acupoints ST36 and ST37. Capsaicin administration at these acupoints caused strong pain intensity and extensive pain distribution, with secondary mechanical hyperalgesia and heat hypoalgesia. Heating-needle stimulation at ST36 enhanced heat pain threshold and alleviated muscle pain.
A randomized, double-blind, placebo-controlled trial of injected capsaicin for pain in Morton's neuroma.
A randomized double-blind placebo-controlled study tested the efficacy, tolerability, and safety of a single 0.1 mg dose of capsaicin vs placebo injected into the region of Morton's neuroma. Capsaicin significantly reduced pain at weeks 1 and 4, with improvements in functional interference scores and reductions in oral analgesic use.
The effect of local vs remote experimental pain on motor learning and sensorimotor integration using a complex typing task.
Two experiments were conducted to determine the effects of capsaicin-induced acute pain on motor learning and sensorimotor processing. Experiment 1 compared acute pain vs control, while Experiment 2 compared local vs remote acute pain. Results showed changes in somatosensory evoked potential amplitudes and improvements in motor learning accuracy and response time, suggesting that acute pain may enhance focal attention during motor learning.
Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: a multicentre, randomized, assessor-blinded study.
Multicentre, randomized, assessor-blinded study assessing tolerability of the capsaicin 8% patch in 122 patients with peripheral neuropathic pain following pretreatment with lidocaine or tramadol. The capsaicin patch was tolerated by 121 patients, with similar tolerability between lidocaine and tramadol pretreatments. Tramadol-treated patients experienced greater pain relief after patch removal.
A placebo-controlled trial of an oral capsaicin load in patients with functional dyspepsia.
Double-blind, placebo-controlled trial of 116 outpatients with upper GI symptoms, including 73 with functional dyspepsia, testing an oral capsaicin load. Capsaicin ingestion resulted in higher median perception scores compared to placebo, indicating chemical hypersensitivity in functional dyspepsia patients.
Capsaicin provocation using two different inhalation devices.
The study aimed to transfer the capsaicin inhalation test from the outdated Pari Boy device to the Maxin MA3 device in patients with sensory hyperreactivity (SHR) and healthy controls. The study found that the Maxin MA3 device showed good repeatability and agreement with the Pari Boy device in terms of capsaicin-induced cough response.
Topical medications for orofacial neuropathic pain: a review.
Systematic review of local pharmacotherapy for chronic orofacial neuropathic pain disorders, focusing on local anesthetics and capsaicin. The review discusses medication delivery methods and highlights the development of a vehicle-carrier agent for improved delivery. Limited empirical data on efficacy is noted, with a call for further research.
Treatments for postherpetic neuralgia--a systematic review of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials for postherpetic neuralgia treatments. Tricyclic antidepressants showed significant pain relief. Capsaicin showed a statistically significant benefit when one heterogeneous study was omitted, though blinding issues may have influenced results. Other treatments like lorazepam, acyclovir, topical benzydamine, and acupuncture showed no evidence of effectiveness.
The effectiveness of topically applied capsaicin. A meta-analysis.
Meta-analysis of trials on topical capsaicin for diabetic neuropathy, osteoarthritis, post-herpetic neuralgia, and psoriasis. Capsaicin cream provided more pain relief than placebo in diabetic neuropathy, osteoarthritis, and psoriasis, with significant odds ratios and rate differences favoring capsaicin.
Clinical characteristics of functional dyspepsia depending on chemosensitivity to capsaicin.
RCT involving 49 functional dyspepsia patients assessing chemosensitivity to capsaicin. Patients were stratified into capsaicin positive and negative groups based on symptomatic response. Capsaicin ingestion for 4 weeks reduced upper gastrointestinal symptoms in both groups, with greater reduction in capsaicin positive patients. Long-term ingestion turned the capsaicin test negative in 53% of chemosensitive patients.
Antipruritic effect of pretreatment with topical capsaicin 8% on histamine- and cowhage-evoked itch in healthy volunteers: a randomized, vehicle-controlled, proof-of-concept trial.
This randomized, vehicle-controlled trial investigated the effect of topical capsaicin 8% on evoked itch in 16 healthy volunteers. Capsaicin pretreatment for 24 hours significantly reduced histaminergic and nonhistaminergic itch by about 75%, while a 1-hour treatment reduced nonhistaminergic itch by approximately 60%.
Cerebral Networks Linked to Itch-related Sensations Induced by Histamine and Capsaicin.
This fMRI study explored the central nervous processing of itch induced by histamine and capsaicin, and the influence of low-dose naltrexone. Networks for sensations like 'burning' and 'itching' were identified, with naltrexone reducing fMRI activation and making scratching less pleasant.
A capsaicin (8%) patch in the treatment of severe persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled trial.
This randomized placebo-controlled trial investigated the efficacy of a capsaicin 8% cutaneous patch in treating severe persistent inguinal postherniorrhaphy pain in 46 patients. The study found no significant differences in pain relief between capsaicin and placebo treatments, although a trend toward pain improvement in capsaicin-treated patients was observed 1 month after patch application.
Cough reduction using capsaicin.
RCT with 24 patients and 15 controls testing oral capsaicin for desensitizing cough reflex in chronic unexplained cough. Capsaicin increased cough thresholds and improved cough symptom scores compared to placebo, suggesting desensitization of TRPV1 receptors.
Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise.
RCT with 11 men testing the effects of 500 mg cayenne pepper (1.25 mg capsaicin) and 500 mg evodiamine on energy expenditure and fat oxidation at rest and during exercise. No significant effects on thermogenesis or lipid oxidation were observed.
Capsaicin instillation for postoperative pain following total knee arthroplasty: a preliminary report of a randomized, double-blind, parallel-group, placebo-controlled, multicentre trial.
This randomized, double-blind, placebo-controlled trial investigated the effects of high-concentration capsaicin instillation on postoperative pain and rehabilitation following total knee arthroplasty. Capsaicin reduced opioid use and improved active range of motion at 14 days compared to placebo, despite higher BMIs in the capsaicin group. Pain scores were lower and patient satisfaction was higher in the capsaicin group.
TRP-channel-specific cutaneous eicosanoid release patterns.
The study investigated the functional expression of TRPV1 and TRPA1 in human keratinocytes and fibroblasts, assessing proinflammatory lipid mediator release upon stimulation with capsaicin and allyl isothiocyanate. Capsaicin induced LTB(4) release and reduced PGE(2) levels, while allyl isothiocyanate increased PGE(2) levels. Both agents reduced heat pain thresholds, with allyl isothiocyanate causing long-lasting erythema.
Capsaicin jelly against migraine pain.
RCT on 23 migraineurs testing topical capsaicin 0.1% against vaseline jelly for arterial pain relief. Capsaicin reduced arterial pain by > 50% in 17/23 patients in absence of attack and in 11/17 during mild- to moderate-intensity migraine attacks.