Research
Bupleurum
9 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
A comprehensive review of bupleuri radix and its bioactive components： with a major focus on treating chronic liver diseases.
Systematic review of Bupleuri Radix (BR) and its bioactive components, focusing on its use in treating liver diseases such as hepatitis, steatohepatitis, cirrhosis, and liver cancer. BR exhibits anti-inflammatory, antioxidant, immunomodulatory, and lipid metabolism regulation effects, but also poses potential hepatotoxicity risks.
Role of Medicinal Plants for Liver-Qi Regulation Adjuvant Therapy in Post-stroke Depression: A Systematic Review of Literature.
Systematic review of 42 RCTs with 3612 participants assessing the effectiveness of medicinal plants for Liver-Qi regulation, specifically Chai-hu, as adjuvant therapy for post-stroke depression. MPLR showed a significantly higher effective rate and superior improvements in Hamilton Depression Scale scores compared to controls, with no serious adverse events reported.
Managing Depression withHerbal Formula: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of randomized controlled trials evaluating BC formula (Radix Bupleuri) for major depressive disorder. BC formula alone or with SSRIs was more effective than antidepressants alone at improving depression severity on the Hamilton Rating Scale for Depression. However, the evidence quality was low and studies had high heterogeneity.
A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications.
Systematic review of 128 papers on Radix Bupleuri and its active compounds, saikosaponins. The review highlights their anti-inflammatory, antitumor, antiviral, anti-allergic, immunoregulation, and neuroregulation activities, with potential liver damage as a side effect at high doses.
Effect of traditional Chinese medicine Bupleurum in the treatment of influenza A (H1N1).
The study analyzes the effect of Bupleurum compound medicine in treating influenza A (H1N1), using oseltamivir as a control. The results showed that the Chinese medicine chima qingwen decoction had certain antiviral effects with an overall effective rate of 93.3% and no adverse reactions.
Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique.
The study used a GC-MS based metabolomics approach to identify metabolic differences between healthy volunteers and depressed patients treated with Xiaoyaosan (XYS). Significant differences in metabolite levels were observed, with XYS reversing changes in glyoxylate and dicarboxylate metabolism, fatty acid biosynthesis, and amino acid biosynthesis. The study suggests potential diagnostic biomarkers for depression.
Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study.
A randomized, open-label, 3-arm, 3-period, crossover trial was conducted on 21 healthy Japanese volunteers to study the pharmacokinetics of Yokukansan (YKS), a traditional Japanese herbal medicine. The study measured plasma concentrations of three active compounds in YKS, demonstrating rapid absorption and elimination of geissoschizine methyl ether and hirsuteine, and slower pharmacokinetics for 18β-glycyrrhetinic acid.
Treatment of primary thrombocytopenic purpura by modified minor decoction of bupleurum.
The paper discusses the treatment of primary thrombocytopenic purpura using a modified minor decoction of bupleurum. No abstract is available to provide further details.
Botany, traditional uses, phytochemistry, analytical methods, processing, pharmacology and pharmacokinetics of Bupleuri Radix: A systematic review.
This systematic review covers the botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics of Bupleuri Radix (BR), the dry root of Bupleurum chinense and Bupleurum scorzonerifolium. It discusses the traditional applications, analytical methods, quality control, and processing methods of BR, highlighting the need for further research into its mechanisms and therapeutic potential.