Research
Broccoli Sprouts (Sulforaphane)
13 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.
RCT of 291 participants in China evaluating a broccoli sprout-derived beverage containing glucoraphanin and sulforaphane for detoxication of airborne pollutants. The intervention increased excretion of benzene and acrolein-derived mercapturic acids, suggesting enhanced detoxication of some pollutants.
Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.
RCT in Qidong, China, testing hot water infusions of broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols. No significant differences between intervention arms, but inverse associations were observed between dithiocarbamate excretion and both aflatoxin-DNA adducts and phenanthrene tetraols.
Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study.
Randomized, double-blind, placebo-controlled trial assessing the effects of broccoli sprout homogenates (BSH) on nasal cytokines, virus replication, and Nrf2-dependent enzyme expression in smokers and nonsmokers. BSH significantly reduced IL-6 responses and influenza sequences in nasal lavage fluid from smokers, and increased NAD(P)H: quinone oxidoreductase in NLF cells.
Broccoli sprouts powder could improve serum triglyceride and oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.
RCT of 81 type 2 diabetic patients comparing 10g/d and 5g/d broccoli sprout powder to placebo for 4 weeks. The 10g/d dose significantly decreased serum triglycerides, OX-LDL/LDL ratio, and atherogenic index of plasma, and increased HDL-C concentration, suggesting favorable effects on lipid profiles and cardiovascular risk factors.
Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.
RCT investigating the effects of broccoli sprouts powder (BSP) on insulin resistance in type 2 diabetic patients. 81 patients were randomized to receive 10 g/d BSP, 5 g/d BSP, or placebo for 4 weeks. Consumption of 10 g/d BSP significantly decreased serum insulin concentration and HOMA-IR, suggesting improvement in insulin resistance.
Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial.
Double-blind, placebo-controlled RCT with 63 type 2 diabetes patients testing broccoli sprouts powder (BSP) effects on oxidative stress parameters. BSP significantly decreased malondialdehyde, oxidized LDL cholesterol, and oxidative stress index, and increased total antioxidant capacity after 4 weeks.
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.
Crossover clinical trial in Qidong, China, evaluating sulforaphane-rich and glucoraphanin-rich broccoli sprout beverages on detoxification of airborne pollutants. Statistically significant increases in excretion of glutathione-derived conjugates of pollutants were observed, suggesting enhanced detoxication.
Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects.
In a controlled study with 40 overweight subjects, the consumption of 30g/day of broccoli sprouts for 10 weeks significantly decreased IL-6 and C-reactive protein levels, indicating an anti-inflammatory effect. The study suggests broccoli sprouts may have beneficial properties in reducing inflammation.
A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics.
RCT comparing the effects of broccoli sprouts to placebo (alfalfa sprouts) on airway inflammation and oxidative stress markers in 40 adults with asthma. Broccoli sprouts did not reduce airway inflammation or improve oxidative stress markers despite increasing serum sulforaphane levels.
Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study.
Randomized, double-blind study examining the effects of sulforaphane-containing broccoli sprout homogenates (BSH) on peripheral blood immune cell responses in healthy volunteers inoculated with live attenuated influenza virus (LAIV). BSH supplementation increased virus-induced peripheral blood NK cell granzyme B production, potentially enhancing antiviral defense responses.
Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial.
The POUDER trial is a randomized controlled pilot study evaluating the feasibility of using freeze-dried broccoli sprouts in patients with advanced pancreatic ductal adenocarcinoma. The study involves 40 patients receiving either broccoli sprout capsules or placebo alongside palliative chemotherapy, assessing feasibility, adverse effects, compliance, serum tumor markers, quality of life, and survival rates.
Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts.
Phase 1 study with 12 healthy subjects consuming 100 g/day of broccoli sprouts for 1 week. The study found decreased total and LDL cholesterol, increased HDL cholesterol, and reduced oxidative stress markers, indicating improved cholesterol metabolism and decreased oxidative stress.
Dietary sulforaphane glucosinolate alleviates stress-induced depression and demyelination through gut-brain axis modulation.
Animal study investigating the effects of an 8-week diet supplemented with 0.1% sulforaphane glucosinolate (SGS) on stress-induced depression and demyelination in mice. SGS pre-treatment reduced immobility in the forced swim test and attenuated myelin loss in the corpus callosum, suggesting stress resilience and preservation of white matter integrity through gut-brain axis modulation.