Research
Borage Oil (GLA)
17 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Borage oil intake by overweight young adults: no effect on metabolic rate; beneficial effects on plasma triglyceride and HDL cholesterol readings.
RCT in overweight young adults with a family history of obesity, testing borage oil (880 mg GLA per day) and evening primrose oil (540 mg GLA per day) for 6 weeks. Borage oil had no effect on resting metabolic rate but lowered plasma triglyceride readings and raised HDL cholesterol readings.
Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.
This randomized, double-blind, crossover intervention study examined the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and gamma-linolenic acid-containing botanical oils in 64 healthy adults. Borage oil supplementation increased serum concentrations of GLA and DGLA in a genotype-dependent manner, while soybean oil did not alter n-6 long-chain PUFA levels. The study suggests the importance of considering FADS genetic variation in clinical studies with GLA-containing oils.
Functional textiles for atopic dermatitis: a systematic review and meta-analysis.
Systematic review and meta-analysis of functional textiles in atopic dermatitis treatment, including silk, silver-coated cotton, borage oil, and EVOH fiber. Borage oil showed improvement in skin erythema, while silver textiles and silk were associated with improvements in SCORAD and symptoms. The recommendation for functional textiles is weak due to low quality of evidence.
Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis.
The study investigated the effects of lipase-treated borage oil (LT-BOL) on melanogenesis. LT-BOL reduced melanin and tyrosinase levels in murine melanocytes and improved skin brightness in a clinical trial with 21 Korean female adults, suggesting its potential as a natural skin whitening product.
Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function.
RCT investigating the effects of a fermented dairy product containing borage oil, green tea catechins, vitamin E, and probiotics on skin barrier function in female volunteers with dry and sensitive skin. The product improved stratum corneum barrier function and reduced transepidermal water loss compared to a control product over 24 weeks.
Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children.
RCT studying the effect of undershirts coated with borage oil on alleviating symptoms of atopic dermatitis in children.
Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial.
RCT of borage oil containing gamma linolenic acid in 140 patients with atopic eczema. The mean SASSAD score fell slightly in both groups, with no significant difference between borage oil and placebo. Gamma linolenic acid was not beneficial for atopic dermatitis.
Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants.
RCT involving 66 premature infants randomized to receive formulas with borage oil, borage oil plus fish oil, or human milk. The study found no significant differences in arachidonic acid status or anthropometric measures between groups, indicating limited effect of GLA on AA status.
The activity of lysosomal exoglycosidases in serum of alcohol-dependent men supplemented with borage oil enriched with vitamin E.
The study assessed the activity of lysosomal exoglycosidases in serum of alcohol-dependent men supplemented with borage oil enriched with vitamin E. The specific activity of MAN and GLUCUR increased significantly in alcohol-dependent men compared to social drinkers, with fluctuations observed in those supplemented with borage oil and vitamin E. FUC activity showed a tendency to increase in alcohol-dependent men and decreased with supplementation. Overall, supplementation did not change the rate of catabolism of glycoconjugates' oligosaccharide chains.
Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial.
Double-blind, placebo-controlled clinical trial evaluating the effects of undershirts coated with borage oil on atopic dermatitis in 32 children. The borage oil group showed statistically significant improvements in erythema and itch, and decreased transepidermal water loss, with no side-effects.
Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis.
RCT of 30 adults with periodontitis testing fish oil and borage oil supplementation. Borage oil showed significant improvement in gingival inflammation and probing depth compared to placebo. Fish oil and combination treatments showed trends but were not statistically significant.
Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema.
Double-blind, multicentre RCT of 160 adults with atopic eczema comparing borage oil (23% GLA) to placebo over 24 weeks. Overall response to borage oil did not reach statistical significance, but a subgroup showed improvement. GLA metabolites increased in borage oil-treated patients, and serum IgE showed a trend to decrease.
A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers.
The study investigates the effect of a therapeutic dosage (3 g/day) of borage oil supplementation on platelet aggregation in healthy volunteers, finding no significant effect.
Malassezia furfur in infantile seborrheic dermatitis.
Study of 21 children with infantile seborrheic dermatitis treated topically with borage oil containing 25% gammalinolenic acid. No reduced growth of Malassezia furfur was observed, suggesting the growth of M. furfur is not related to clinical symptoms in ISD.
Alteration of baroreflex control of forearm vascular resistance by dietary fatty acids.
RCT studying the effects of dietary safflower, borage, and fish oil on cardiovascular responses to lower body negative pressure in normotensive humans. Borage oil augmented arterial baroreflex control of vascular resistance, while fish oil increased forearm blood flow after forearm ischemia.
Dietary fatty acid supplementation alters stress reactivity and performance in man.
RCT with 30 men assigned to borage oil, fish oil, or olive oil for 28 days. Borage oil attenuated blood pressure and heart rate responses to stress, increased skin temperature, and improved task performance, suggesting dietary modification can alter stress reactivity.
Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation.
Cross-sectional study and dietary supplementation trial comparing essential fatty acid levels in breast milk of atopic and non-atopic mothers. Borage oil supplementation increased gamma-linolenic acid levels in breast milk of atopic mothers but did not restore arachidonic acid levels.