Research
Beta-Glucan
111 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Cereal beta-glucan and cardiovascular disease risk reduction in overweight and obese populations: a systematic review and meta-analysis of lipid, blood pressure, and anthropometric parameters.
Systematic review and meta-analysis of 49 studies involving 3854 subjects assessing the effects of cereal beta-glucan on lipids, blood pressure, and anthropometric parameters in overweight and obese individuals. Cereal beta-glucan significantly reduced total cholesterol and LDL cholesterol, and oat beta-glucan modestly lowered systolic blood pressure.
Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.
A double-blind, placebo-controlled multicentre clinical trial evaluated the effects of pleuran (β-glucan from Pleurotus ostreatus) on asthma control and respiratory tract infections in children with perennial asthma. The study found significant improvements in asthma control and reduced respiratory tract infections in children receiving pleuran/vitamin C compared to those receiving vitamin C only.
Supplementation with a β-glucan tablet has no effect on hyperlipidemia: a randomized, placebo-controlled clinical trial.
A randomized, placebo-controlled trial evaluated the efficacy of β-glucan supplementation on lipid levels in subjects with hyperlipidemia. The study found no significant effect of β-glucan on LDL cholesterol or other lipid subfractions compared to placebo.
Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 74 RCTs assessing oat supplementation interventions on cardiovascular disease risk markers among adults. Oat supplementation improved total cholesterol, LDL cholesterol, glucose, BMI, weight, and waist circumference. Findings on inflammation and oxidative stress markers were inconsistent.
The separate effects of whole oats and isolated beta-glucan on lipid profile: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the impact of oats and isolated beta-glucan supplements on lipid profiles. The analysis included 28 studies with 1494 subjects, showing that both oat and isolated beta-glucan interventions improved total cholesterol and LDL levels, with no effect on HDL. These findings suggest that these supplements are effective tools for combating dyslipidemia and may aid in cardiovascular disease prevention.
Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 13 RCTs with 927 participants examining the effects of oat beta-glucan on lipid profiles in hypercholesterolemic adults. Oat beta-glucan significantly reduced total cholesterol and LDL-c levels, but showed no significant effects on triglycerides and HDL-c.
The importance of molecular weight in determining the minimum dose of oat β-glucan required to reduce the glycaemic response in healthy subjects without diabetes: a systematic review and meta-regression analysis.
Systematic review and meta-regression analysis of 59 comparisons (n=340) examining the effects of oat beta-glucan (OBG) on glycaemic responses in healthy subjects without diabetes. The study determined the minimum dose of OBG required to reduce glucose iAUC and iPeak, with linear associations found between OBG dose and glucose responses. MinDoses for glucose iAUC were estimated for different molecular weights of OBG.
Primary care experience on Stimunexgocce in children with recurrent respiratory infections: a real-world study during the COVID-19 pandemic era.
This real-world study investigated the effect of Stimunexgocce, a multicomponent food supplement, on preventing recurrent respiratory infections (RRI) in children. The supplement, containing Sambucus nigra extract, β-glucan, Zinc, and Vitamin D3, was given to 160 children, resulting in significantly fewer and shorter respiratory infections compared to the control group.
Effect of Oat (Avena sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-density Lipoprotein Cholesterol (HDL-C): An Updated Systematic Review.
Systematic review of 17 studies examining the effect of oat consumption on lipid profiles, particularly triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C). Oat consumption was found to significantly reduce total cholesterol (TC), very low-density lipoprotein cholesterol (VLDL), and low-density lipoprotein cholesterol (LDL-C) more than TG. Some studies reported TG reduction and HDL-C improvement with oat intake, especially in specific populations or with higher doses and longer durations.
The effect of oat β-glucan on postprandial blood glucose and insulin responses: a systematic review and meta-analysis.
Systematic review and meta-analysis of 103 trial comparisons with 538 participants examining the effect of oat beta-glucan (OBG) on postprandial glucose and insulin responses. OBG reduced glucose and insulin responses significantly, with the magnitude of reduction influenced by dose, molecular weight, and comparator meal type. High certainty of evidence supports these findings.
Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains.
RCT of 207 participants with borderline high LDL-cholesterol comparing oat beta-glucan (OBG) to control beverage over 4 weeks. OBG reduced the occurrence of exhaustion and fatigue, and decreased severity of headache, anxiety, limb/joint pain, and difficulty concentrating compared to baseline.
Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies.
Systematic review and meta-analysis of preclinical studies on yeast beta-glucan ingestion in rodents. The analysis found that yeast beta-glucan barely affects body weight in both obese and non-obese animals, with no significant effect observed.
Effects of fungal beta-glucans on health - a systematic review of randomized controlled trials.
Systematic review of 34 RCTs assessing the effects of fungal beta-glucans on health outcomes. The primary outcome was immunomodulation, with strengthened immune defense reducing the incidence and symptoms of respiratory infections and improving allergic symptoms. Psychological wellbeing and mood states also improved. No adverse events were recorded.
Fungal beta-glucans as adjuvants for treating cancer patients - A systematic review of clinical trials.
Systematic review of 16 clinical trials involving 1650 cancer patients using fungal β-glucans as adjuvants. The review found that β-glucans are safe and may reduce immune depression from chemo or radiotherapy, though results were mixed and further evidence is needed to confirm efficacy.
Effects of different delivering matrices of β-glucan on lipids in mildly hypercholesterolaemic individuals: a meta-analysis of randomised controlled trials.
Meta-analysis of 21 RCTs involving 1120 participants with mild hypercholesterolemia. Consuming ≥3 g/d of β-glucan for at least 3 weeks significantly reduced total cholesterol and LDL-cholesterol, but not TAG or HDL-cholesterol. Different food matrices affected the efficacy of β-glucan.
The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials.
Systematic review and meta-analysis of 58 RCTs with 3974 participants assessing the cholesterol-lowering potential of oat β-glucan. A median dose of 3.5 g/d significantly lowered LDL-cholesterol, non-HDL-cholesterol, and apoB, suggesting oat β-glucan may help reduce CVD risk.
Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects.
Meta-analysis of 17 RCTs with 916 hypercholesterolemic subjects assessing beta-glucan consumption. Beta-glucan significantly lowered total cholesterol and LDL-cholesterol concentrations but did not affect triglycerides, HDL-cholesterol, and glucose levels.
A systematic review and meta-analysis of beta-glucan consumption on glycemic control in hypercholesterolemic individuals.
Systematic review and meta-analysis of 12 RCTs with 603 subjects evaluating beta-glucan consumption from oats or barley on glycemic control in hypercholesterolemic individuals. Beta-glucan consumption did not significantly affect fasting glucose or insulin concentrations.
The effects of barley-derived soluble fiber on serum lipids.
Meta-analysis of 8 trials with 391 patients evaluating the lipid-reducing effects of barley-derived soluble fiber. Barley significantly lowered total cholesterol, LDL cholesterol, and triglycerides, but did not significantly alter HDL cholesterol.
Effectiveness of regular oat β-glucan-enriched bread compared with whole-grain wheat bread on long-term glycemic control in adults at risk of type 2 diabetes: a randomized controlled trial.
A 16-week randomized controlled trial in 194 adults at risk of type 2 diabetes compared the effects of β-glucan-enriched bread to whole-grain wheat bread on glycemic control. The study found no significant differences in HbA1c, fasting glucose, insulin, or LDL cholesterol between the groups, suggesting no metabolic benefits of oat-derived β-glucan-enriched bread under real-life conditions.
Yeast Beta-Glucan Enhances Antibody Response Following Influenza Vaccination - A Double-Blind, Randomized, Placebo-Controlled Pilot Trial.
This double-blind, randomized, placebo-controlled pilot trial assessed the adjuvant effect of yeast beta-glucan supplementation on antibody titer response to influenza vaccination in 90 adults. The study found that yeast beta-glucan may enhance the antibody response to the influenza vaccine, although further confirmation with a larger sample is needed.
The effects of waxy barley on defecation, sleep, mental health, and quality of life: a randomized double-blind parallel-group comparison study.
A randomized double-blind parallel-group study on 68 young Japanese women examined the effects of waxy barley consumption on defecation, sleep, mental health, and quality of life. Both common and high-β-glucan waxy barley improved defecation frequency and stool amount. High-β-glucan waxy barley showed improvements in sleep and mental health scores.
Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial.
This randomized, double-blind, placebo-controlled trial assessed the effects of β-glucan-rich barley dietary fiber (BDF) on postprandial blood glucose, insulin, glucagon, triglycerides, and appetite-related hormones in 67 healthy adults. BDF consumption significantly delayed postprandial blood glucose increase, reduced insulin secretion, and increased satiety, suggesting potential benefits for metabolic health.
Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma: A Phase 2 Randomized Clinical Trial.
Phase 2 RCT of 107 patients with high-risk neuroblastoma testing oral beta-glucan as an adjuvant during GD2/GD3 ganglioside vaccine priming. Beta-glucan increased anti-GD2 IgG1 titer among genetic responders without added toxic effects, though no difference in seroconversion rates was detected.
Combined effect of polycan, a β-glucan from, and regular resistance exercise on muscle strength, biomarkers, and fitness profiles in adults with relatively low skeletal muscle mass: a randomised controlled trial.
RCT of 80 adults aged ≥50 years with low skeletal muscle mass, comparing 1000 mg of APβG per day plus resistance exercise to placebo for 12 weeks. The combination improved knee flexion strength, handgrip strength, and reduced time for the 400 m walk test compared to placebo, with no adverse events reported.
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
A 36-week randomized, double-blind, placebo-controlled trial in 65 ME/CFS patients examined the effects of beta-glucan supplementation with multivitamins. The study found that beta-glucan significantly improved cognitive fatigue compared to baseline, suggesting its potential as a nutritional supplement to reduce cognitive dysfunction in ME/CFS.
The Effect of ß-Glucan Prebiotic on Kidney Function, Uremic Toxins and Gut Microbiome in Stage 3 to 5 Chronic Kidney Disease (CKD) Predialysis Participants: A Randomized Controlled Trial
RCT investigating the effect of ß-glucan prebiotic on kidney function, uremic toxins, and gut microbiome in stage 3 to 5 CKD participants. No significant changes in kidney function were observed, but there was a significant reduction in uremic toxin levels and favorable effects on the gut microbiome.
Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study.
This study evaluated the efficacy and tolerance of a topical regimen containing beta-glucan, 1565-nm non-ablative fractional laser (NAFL), and their combination for treating striae gravidarum. The study involved 64 subjects with 128 unilateral abdomens, divided into four treatment strategies. Results showed that NAFL had better outcomes than beta-glucan alone, and the combination of beta-glucan and NAFL further improved striae atrophy compared to single treatments.
Oats Lower Age-Related Systemic Chronic Inflammation (iAge) in Adults at Risk for Cardiovascular Disease.
A placebo-controlled RCT investigated the effects of an oat product providing 3 g of β-Glucan on systemic chronic inflammation (SCI) and cardiovascular risk in adults with borderline high cholesterol. The oat product reduced Inflammatory Age® (iAge®) and improved LDL cholesterol levels, showing a novel anti-SCI role for oats.
An Oat β-Glucan Beverage Reduces LDL Cholesterol and Cardiovascular Disease Risk in Men and Women with Borderline High Cholesterol: A Double-Blind, Randomized, Controlled Clinical Trial.
A double-blind, randomized controlled trial evaluated the effect of a beverage containing 3g/day high-molecular-weight oat beta-glucan on LDL cholesterol reduction in adults with borderline high cholesterol. The study found significant reductions in LDL cholesterol and cardiovascular disease risk after 4 weeks of consumption.
β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial.
RCT of 138 participants with protective qi deficiency comparing 200 mg daily β-glucan to placebo for 12 weeks. β-glucan improved protective qi status, URTI symptoms, and physical and mental health scores compared to placebo.
Barley malt-based composition as a galactagogue - a randomized, controlled trial in preterm mothers.
RCT of 80 preterm mothers comparing a galactagogue composition based on barley malt with β-glucan and lemon balm to placebo. The Galactagogue Group showed significantly higher milk volume compared to the Placebo Group, indicating increased milk output.
Serum Metabolomics Reveals Underlying Mechanisms of Cholesterol-Lowering Effects of Oat Consumption: A Randomized Controlled Trial in a Mildly Hypercholesterolemic Population.
RCT in 62 adults with mild hypercholesterolemia comparing 80g oats (containing 3g beta-glucan) to rice daily for 45 days. Oat consumption significantly decreased serum total cholesterol, LDL-c, and non-HDL-c levels. Metabolomics analysis revealed changes in metabolic profiles, suggesting mechanisms involving glycerophospholipid, alanine, aspartate and glutamate, sphingolipid, and retinol metabolism.
Acute effect of oat β-glucan on the bioavailability of orange juice flavanones.
RCT investigating the impact of β-glucan on the bioavailability of orange juice flavanones. Volunteers consumed orange juice with or without 3g or 6g of β-glucan. The 6g β-glucan intake significantly reduced the excretion of flavanone metabolites compared to orange juice alone.
Effect of processing on oat β-glucan viscosity, postprandial glycemic response and subjective measures of appetite.
The study examined the effect of processing methods on oat β-glucan viscosity and its impact on postprandial glycemic response. An acute randomized crossover clinical trial tested oatmeal products with varying β-glucan viscosity. Results showed that increased viscosity through processing did not affect postprandial glucose control.
Survival Impact of Anti-GD2 Antibody Response in a Phase II Ganglioside Vaccine Trial Among Patients With High-Risk Neuroblastoma With Prior Disease Progression.
Phase II trial of GD2/GD3 vaccine plus oral β-glucan in 102 patients with high-risk neuroblastoma. The study found that higher anti-GD2-IgG1 titers were associated with improved progression-free and overall survival. The vaccine and β-glucan elicited robust antibody responses.
A randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study.
The BELT Study was an 8-week, double-blind, placebo-controlled, cross-over RCT investigating the effect of 3 g/day oat beta-glucans on plasma lipids, fasting glucose, and intestinal well-being in 83 Italian subjects. Beta-glucans significantly reduced LDL-C, TC, and non-HDL-C levels, but had no effect on fasting glucose or intestinal well-being.
Effects of cereal beta-glucan consumption on body weight, body mass index, waist circumference and total energy intake: A meta-analysis of randomized controlled trials.
Meta-analysis of 20 RCTs investigating the effect of cereal beta-glucan consumption on body weight, BMI, waist circumference, and energy intake. Beta-glucan consumption significantly reduced body weight and BMI, but had no effect on waist circumference and energy intake.
Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial.
This double-blind, randomized, placebo-controlled trial examined the effect of dairy-based beverages containing 250mg of dispersible yeast beta-glucan on upper respiratory tract infection (URTI) in marathon runners. Participants consuming beta-glucan reported significantly fewer URTI symptomatic days, lower severity of specific URTI symptoms, and fewer missed postmarathon workout days due to URTI compared to the control group.
Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects.
This double-blind, randomized, placebo-controlled study evaluated the effects of yeast beta-glucan on upper respiratory tract infections (URTIs) in 299 healthy subjects. While the incidence and global severity of URTIs were similar between groups, yeast beta-glucan reduced the severity of physical symptoms during the first week of an episode and improved mood and blood pressure.
Effects of dietary fibre type on blood pressure: a systematic review and meta-analysis of randomized controlled trials of healthy individuals.
Systematic review and meta-analysis of randomized controlled trials assessing the effect of dietary fibre on blood pressure. Beta-glucans were found to reduce systolic blood pressure by 2.9 mmHg and diastolic blood pressure by 1.5 mmHg. The study supports increasing consumption of beta-glucan-rich foods like oats and barley.
An evidence-based systematic review of beta-glucan by the natural standard research collaboration.
Systematic review of beta-glucan by the Natural Standard Research Collaboration, consolidating safety and efficacy data from scientific literature. Includes analysis of clinical trials, expert opinion, history, pharmacology, interactions, adverse effects, and dosing.
Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials.
Meta-analysis of 28 RCTs assessing the effect of ≥3 g/day oat beta-glucan on serum cholesterol concentrations. Oat beta-glucan reduced LDL and total cholesterol by 0.25 mmol/L and 0.30 mmol/L, respectively, without affecting HDL cholesterol or triglycerides. Greater effects were observed in subjects with higher baseline LDL cholesterol and those with diabetes.
Effects of single or combined dietary supplementation of β-glucan and kefir on growth performance, blood characteristics and meat quality in broilers.
This study evaluated the effects of dietary beta-glucan and kefir on growth performance, blood profiles, relative organ weight, and meat quality in broilers. Broilers given beta-glucan and kefir, either individually or combined, showed improved growth performance and meat quality compared to the control group.
Cereal β-glucan alters nutrient digestibility and microbial activity in the intestinal tract of pigs, and lower manure ammonia emission: a meta-analysis.
Meta-analysis of 26 studies examining the effects of dietary beta-glucan on nutrient digestibility, intestinal fermentation, and manure ammonia emission in pigs. Increasing beta-glucan reduced nutrient digestibility but stimulated cecal butyrate production and reduced ammonia emissions. The effects varied with pig body weight and dietary composition.
Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians.
A randomized, controlled, double-blind, multi-center clinical trial examined the effect of oat β-glucan on LDL cholesterol levels in Caucasians and non-Caucasians. The study found that high and medium molecular-weight oat β-glucan significantly reduced LDL cholesterol by 4.8 to 6.5% compared to control, with no significant difference in effect between ethnicities.
Meta-analysis of the effect of β-glucan intake on blood cholesterol and glucose levels.
Meta-analysis of 126 clinical studies assessing the effect of β-glucan from oats and barley on blood cholesterol and glucose levels. Significant reductions in total cholesterol and low-density lipoprotein were observed, while the effect on blood glucose levels was inconclusive with high heterogeneity.
Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial.
A randomized clinical trial investigated the effect of oat β-glucan on LDL cholesterol levels in humans. The study found that consumption of 3 g high-MW or medium-MW oat β-glucan significantly reduced LDL cholesterol compared to wheat fiber, while low-MW oat β-glucan had no significant effect. The cholesterol-lowering ability was related to the molecular weight and solubilization of oat β-glucan.
[Role of beta-glucan in the treatment of recurrent candidiasis and HPV-correlated lesions and reparative process of epidermis].
RCT examining the effects of beta-glucan treatment in women with recurrent vulvar candidiasis or HPV-correlated vulvar lesions. Beta-glucan was applied topically for two cycles, showing efficacy in reducing disease recurrence and aiding epidermal repair.
β-glucan from barley and its lipid-lowering capacity: a meta-analysis of randomized, controlled trials.
Meta-analysis of 11 randomized clinical trials assessing the effect of barley beta-glucan on blood lipid concentrations. Barley beta-glucan significantly lowered total and LDL cholesterol concentrations compared to control, suggesting a dietary approach to reduce LDL cholesterol.
Could β-glucans enhance the immune response to SARS-CoV-2 vaccine by inducing trained immunity and boosting neutralizing antibody production?
The study evaluated the effect of 500 mg oral insoluble yeast β-glucans on immune response to SARS-CoV-2 vaccination in 34 non-immune men. The glucan group showed higher levels of neutralizing antibodies and anti-S1 IgG after the booster dose compared to the placebo group, suggesting β-glucans may enhance vaccine-induced immunity.
Effect of Focused Ultrasound With or Without Anti-HPV β-Glucan Therapy on Persistent Cervical HPV Infection: A Randomized Controlled Trial.
RCT of 44 women with persistent HPV infection comparing focused ultrasound alone to combination therapy with anti-HPV β-glucan. The combination group showed a higher HPV negative conversion rate and better restoration of vaginal microecology, including pH balance and reduced inflammation markers.
Barley-Based Cereals Enhance Metabolic Health and Satiety in Overweight Korean Adults: A Randomized Trial.
A 6-week RCT in overweight Korean adults comparing barley-based cereals to corn-based cereals. The barley group showed significant improvements in body weight, BMI, glycated albumin, body fat percentage, waist circumference, waist-to-hip ratio, and LDL cholesterol, suggesting metabolic and satiety benefits.
Irreversible Electroporation and Beta-Glucan-Induced Trained Innate Immunity for Treatment of Pancreatic Ductal Adenocarcinoma: A Phase II Study.
Phase II study testing the combination of irreversible electroporation (IRE) and oral beta-glucan in 30 patients with stage III pancreatic ductal adenocarcinoma. The combination treatment improved disease-free interval and overall survival, with significant immunophenotyping changes observed at 12 months post-IRE.
Effect of oat β-glucan in managing blood pressure: a randomized cross-over pilot trial.
This randomized, double-blinded, cross-over pilot trial investigated the efficacy of HMW oat β-glucan in reducing systolic and diastolic blood pressure in individuals with mild hypertension. The study found that consumption of oat β-glucan breakfast cookies for 4 weeks did not reduce blood pressure compared to a wheat-based control.
High β-Glucan Whole Grain Barley Reduces Postprandial Glycemic Response in Healthy Adults-Part One of a Randomized Controlled Trial.
RCT evaluating the effects of high β-glucan whole grain barley on postprandial blood glucose response in 16 healthy adults. Higher β-glucan content was associated with lower blood glucose peak response and incremental area under the curve estimates, suggesting potential benefits for blood glucose control.
An exploratory clinical study of β-glucan combined with camrelizumab and SOX chemotherapy as first-line treatment for advanced gastric adenocarcinoma.
This phase IB, prospective, single-arm study evaluated the efficacy and safety of β-glucan combined with camrelizumab and SOX chemotherapy in 30 patients with advanced gastric adenocarcinoma. The study found a 60% objective response rate, with a median progression-free survival of 10.4 months and median overall survival of 14.0 months. The treatment showed favorable efficacy and a manageable safety profile.
Effect of combination of Beta Glucan and Lactobacillus rhamnosus HerizI on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: A randomized double-blind placebo-controlled clinical trial.
RCT in 30 women with breast cancer undergoing chemotherapy, testing the effect of Beta Glucan and Lactobacillus rhamnosus Heriz I on white blood cell counts and serum levels of IL-4 and IL-12. White blood cell counts decreased in both groups. Serum IL-4 decreased significantly in the combination group, while IL-12 increased non-significantly.
Effects of Chronic Barley Consumption on Upper Respiratory Tract Symptoms in Japanese Healthy Adults: A Randomized, Parallel-Group, Controlled Trial.
Randomized, parallel-group trial in 27 healthy Japanese adults comparing 100 g of cooked waxy barley (containing 1.8 g of β-glucan) to 100 g of cooked white rice daily for 8 weeks. The barley group reported reduced nasal symptoms and improved mood status compared to the control group.
β-glucan combined with Envafolimab and Endostar as immune rechallenge for metastatic non-small cell lung cancer.
This study investigated the efficacy and safety of β-glucan combined with Envafolimab and Endostar as an immune rechallenge for metastatic non-small cell lung cancer (NSCLC) patients who previously failed anti-PD-1 therapy. The overall response rate was 21.7% and the disease control rate was 73.9%. Median progression-free survival was 4.3 months, with significant differences between PD-L1 positive and negative subgroups. Treatment-related adverse events occurred in 52.2% of patients.
Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention.
Randomised, crossover, blind trial in 29 overweight/obese volunteers consuming supplements of green coffee polyphenols, oat beta-glucans, or their combination for 8 weeks. Only VLDL-C and diastolic blood pressure decreased, particularly with the oat beta-glucan supplement. No significant changes in other cardiometabolic biomarkers were observed.
Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases.
Randomized pilot clinical study evaluating the gut microbiota of subjects with ASD after consumption of Nichi Glucan. The study found a decrease in Enterobacteriaceae and an increase in beneficial bacteria like Faecalibacterium prausnitzii and Prevotella copri in the group supplemented with Nichi Glucan, suggesting a positive effect on gut microbiome balance and potential prophylactic role in neurodegenerative diseases.
Clinical Outcomes after Oat Beta-Glucans Dietary Treatment in Gastritis Patients.
RCT studying the effect of oat beta-glucan preparations with different molar masses in 48 patients with chronic gastritis. High molar mass oat beta-glucans showed beneficial effects, reducing mucosal damage and improving SCFA fecal concentration and antioxidant defense parameters after 30 days.
Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study.
Pilot clinical study of beta glucans from Aureobasidium pullulans strains AFO-202 and N-163 in 24 COVID-19 patients. The study found decreased D-Dimer and IL-6 levels in groups receiving beta glucans, suggesting potential benefits in managing cytokine storm and coagulopathy.
Effects of β-glucan and inulin consumption on postprandial appetite, energy intake and food consumption in healthy females: A randomized controlled trial.
RCT investigating the effects of beta-glucan and inulin on satiety and food intake in 24 healthy females. Both dietary fibers significantly reduced hunger and energy intake, with beta-glucan showing significant reductions in body weight, BMI, and waist circumference, while inulin significantly reduced body fat percentage.
Yeast Beta-Glucan Supplementation Downregulates Markers of Systemic Inflammation after Heated Treadmill Exercise.
This RCT studied the effects of 250 mg/day yeast beta-glucan supplementation on inflammation and muscle damage in healthy, active men and women after heated treadmill exercise. The yeast beta-glucan group showed lower serum pro-inflammatory cytokines compared to placebo, indicating favorable changes in inflammation markers.
Increasing oat β-glucan viscosity in a breakfast meal slows gastric emptying and reduces glycemic and insulinemic responses but has no effect on appetite, food intake, or plasma ghrelin and PYY responses in healthy humans: a randomized, placebo-controlled, crossover trial.
A randomized, placebo-controlled, crossover trial investigated the effect of oat beta-glucan viscosity in a breakfast meal on gastric emptying and glycemic and insulinemic responses in healthy humans. The study found that increased viscosity of oat beta-glucan reduced postprandial glucose and insulin levels and delayed gastric emptying, but had no significant effect on appetite, food intake, or plasma ghrelin and PYY responses.
Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study.
Split-face, double-blinded, vehicle-controlled study evaluating skin care regimens containing beta-glucan for post-laser skin recovery in 20 patients. The treatment side showed improved hemoglobin index, skin hydration, and reduced transepidermal water loss compared to control, with 63.2% of subjects reporting better repair effects.
Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans.
RCT studying the effect of varying molecular weight and viscosity of oat β-glucan on postprandial glycemic response in 16 healthy subjects. No significant differences were found for glucose peak-rise or iAUC over 0-120 min, but lower molecular weight and viscosity were associated with higher iAUC over 0-45 min and shorter time to peak glucose.
Bile Acids in Patients with Uncontrolled Type 2 Diabetes Mellitus - The Effect of Two Days of Oatmeal Treatment.
The study investigated the effect of two days of oatmeal treatment on bile acid concentration in patients with uncontrolled type 2 diabetes. Oatmeal treatment led to significant reductions in total bile acids compared to a diabetes-adapted control diet, with reductions correlated with a decrease in proinsulin.
High molecular weight oat β-glucan enhances lipid-lowering effects of phytosterols. A randomised controlled trial.
This RCT investigated the effects of dietary supplementation with high molecular weight oat beta-glucan (OBG) and phytosterols (PS) on plasma lipids in hypercholesterolaemic individuals. The study found that both OBG and PS significantly lowered total cholesterol and LDL-cholesterol, with the combination of OBG and PS showing an additive effect, enhancing lipid-lowering potential and providing heart health benefits.
Oat porridge consumption alleviates markers of inflammation and oxidative stress in hypercholesterolemic adults.
A randomized crossover study investigated the effect of oat porridge consumption on inflammatory and oxidative stress markers in hypercholesterolemic adults. Oat porridge consumption significantly decreased levels of hsCRP, IL-6, IL-8, and TNF-α, and increased antioxidant capacity (ORAC and FRAP levels), suggesting potential benefits for reducing inflammation and oxidation.
A randomized, controlled trial evaluating the efficacy and safety of BTH1677 in combination with bevacizumab, carboplatin, and paclitaxel in first-line treatment of advanced non-small cell lung cancer.
This phase II randomized controlled trial evaluated the efficacy, pharmacokinetics, and safety of BTH1677, a beta-glucan, in combination with bevacizumab, carboplatin, and paclitaxel in patients with untreated advanced non-small cell lung cancer. The BTH1677 arm showed higher objective response rates and other clinical endpoints compared to the control arm, though differences were not statistically significant. A higher incidence of Grade 3/4 adverse events was observed in the BTH1677 arm, but no unexpected adverse events occurred.
Effects of β-glucan and Vitamin D Supplementation on Inflammatory Parameters in Patients with Diabetic Retinopathy.
RCT evaluating the effects of beta-glucan and vitamin D supplementation on inflammatory parameters in 52 patients with diabetic retinopathy. Significant changes in CRP levels and leptin were observed in the beta-glucan-supplemented group, while SAA and IL-6 levels were unchanged. Vitamin D deficits persisted despite supplementation.
Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study.
A randomized, double-blind, placebo-controlled study with 100 Japanese individuals investigated the effects of substituting high β-glucan barley for rice on visceral fat obesity. The test group consuming high β-glucan barley showed greater reductions in body weight, BMI, and visceral fat area compared to the placebo group, particularly in participants with a visceral fat area ≥100 cm².
A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3-1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer.
Phase II RCT evaluating BTH1677 (1,3-1,6 beta-glucan) combined with cetuximab and chemotherapy in advanced NSCLC patients. BTH1677 improved objective response rate compared to control, with consistent pharmacokinetics and well-tolerated safety profile. Biomarker-positive patients showed better outcomes.
A Multifunctional Bread Rich in Beta Glucans and Low in Starch Improves Metabolic Control in Type 2 Diabetes: A Controlled Trial.
Controlled trial analyzing the metabolic effects of a functional bread rich in beta glucans and low in starch in people with type 2 diabetes. The functional bread reduced glycated hemoglobin and post-prandial plasma glucose, improving long-term metabolic control.
Effect of purified β-glucans derived from Laminaria digitata, Laminaria hyperborea and Saccharomyces cerevisiae on piglet performance, selected bacterial populations, volatile fatty acids and pro-inflammatory cytokines in the gastrointestinal tract of pigs.
The study compared the effects of purified beta-glucans from Laminaria digitata, L. hyperborea, and Saccharomyces cerevisiae on piglet performance, bacterial populations, and cytokine expression in the gastrointestinal tract. Beta-glucans reduced Enterobacteriaceae populations and down-regulated pro-inflammatory cytokines in the colon, with different mechanisms suggested between soluble and insoluble sources.
Effect of beta-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS.
RCT evaluating the effectiveness of a mixture of beta-glucan, inositol, and digestive enzymes (Biointo) in 50 IBS patients. Biointo administration significantly improved bloating, flatulence, and abdominal pain, but did not show significant effects on other IBS symptoms.
Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes.
Double-blind, placebo-controlled study of pleuran (β-glucan from Pleurotus ostreatus) supplementation in 50 athletes over 3 months. Pleuran significantly reduced the incidence of URTI symptoms and increased NK cell count, with stable phagocytosis compared to placebo.
A controlled study of consumption of beta-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects.
A parallel, placebo-controlled, double-blinded RCT in 53 type 2 diabetic subjects assessed the effects of beta-glucan-enriched soup consumption for 8 weeks. No significant changes were observed in lipid profile or glucose control, except for a significant decrease in TAG levels in the beta-glucan group compared to control.
Physicochemical properties of beta-glucan in differently processed oat foods influence glycemic response.
The study assessed the effect of food processing on oat beta-glucan's ability to attenuate postprandial glycemia. Isocaloric foods containing 4 g of beta-glucan were tested, with porridge and granola showing the highest efficacy in reducing peak blood glucose response due to high molecular weight and viscosity.
Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial.
RCT of 75 hypercholesterolemic adults comparing 6 grams/day concentrated oat beta-glucan to dextrose control for 6 weeks. Oat beta-glucan significantly reduced total and LDL cholesterol compared to baseline and control. It was also found to be a fermentable fiber, producing higher amounts of butyrate than other fibers.
Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides
The study investigates the metabolic benefits of prebiotic exopolysaccharides (EPS) produced by Leuconostoc mesenteroides. Intake of purified EPS improved glucose metabolism and energy homeostasis through gut microbial short-chain fatty acids and altered gut microbial composition.
Consumption of a meal containing refined barley flour bread is associated with a lower postprandial blood glucose concentration after a second meal compared with one containing refined wheat flour bread in healthy Japanese: A randomized control trial.
RCT with 23 healthy young Japanese adults comparing the effects of refined barley flour bread containing 2.5 g β-glucan to refined wheat flour bread on postprandial blood glucose levels. Barley flour bread consumption resulted in significantly lower blood glucose concentrations after both the first and second meals.
Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects.
Randomized double-blind cross-over study in 33 normal-weight subjects examining the effects of 4g high molecular weight oat β-glucan on appetite, glycemia, insulinemia, and GLP-1 concentrations. Oat β-glucan increased feelings of fullness and satiety but did not affect ad libitum eating. It beneficially modulated postprandial glycemia and insulin levels but did not increase plasma GLP-1 secretion.
Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome.
RCT evaluating the efficacy of a mixture of beta-glucan, inositol, and digestive enzymes in 43 IBD patients with IBS symptoms. The group receiving the supplement reported reduced abdominal pain, bloating, and flatulence, with an overall improvement in well-being after four weeks.
Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism.
Controlled, randomised, cross-over study with 30 participants with mild hypercholesterolaemia. Consumption of 3 g high-molecular weight barley β-glucan decreased total cholesterol levels and increased bile acid synthesis, particularly in individuals with the homozygous G allele of rs3808607.
Yeast β-Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects.
RCT of 44 overweight/obese participants comparing yeast β-glucan to placebo for six weeks. β-glucan reduced waist circumference and blood pressure, increased anti-inflammatory cytokine IL-10, and reduced pro-inflammatory cytokines IL-6 and TNF-α, suggesting potential benefits for cardiovascular health and inflammation modulation.
The role of meal viscosity and oat β-glucan characteristics in human appetite control: a randomized crossover trial.
A randomized crossover trial with 48 individuals examined the effect of two types of oatmeal and an oat-based ready-to-eat breakfast cereal on appetite. Instant oatmeal increased fullness, suppressed desire to eat, and reduced prospective intake more than the cereal over four hours. Old-fashioned oatmeal also reduced prospective intake more than the cereal. Oatmeal had higher β-glucan content and viscosity, which may be important for reducing appetite.
Molecular weight of barley β-glucan does not influence satiety or energy intake in healthy male subjects.
RCT investigating the effect of molecular weight of barley β-glucan in a semisolid meal on energy intake and subjective feelings of hunger in 23 healthy male subjects. No significant differences were found in food intake or appetite ratings between high and low molecular weight β-glucan soups and a control soup.
Phase I trial of a bivalent gangliosides vaccine in combination with β-glucan for high-risk neuroblastoma in second or later remission.
Phase I trial of a vaccine containing neuroblastoma-associated antigens GD2 and GD3 with the immunologic adjuvant OPT-821 and oral β-glucan in children with neuroblastoma in second or later remission. The study found no dose-limiting toxicity and reported an 80% relapse-free survival at 24 months. The vaccine and β-glucan were well tolerated, with antibody responses observed in most patients.
Beta-glucan- or rice bran-enriched foods: a comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men.
Crossover clinical trial comparing beta-glucan- and rice bran-enriched foods in mildly hypercholesterolemic men. Beta-glucan-enriched foods were more effective in lowering serum LDL levels compared to rice bran-enriched foods.
Impact of beta-glucan on the faecal microbiota of polypectomized patients: a pilot study.
Pilot RCT studying the effect of barley-derived beta-glucan on gut microbiota in polypectomized patients. No significant differences in bacterial counts between groups, but specific decreases in coliforms and Clostridium perfringens were noted. Changes in volatile fatty acids and gastrointestinal symptoms were observed.
Consumption of oat beta-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects.
RCT with 42 mildly hypercholesterolemic subjects consuming control muesli, beta-glucan muesli, or combination muesli with plant stanols. No differences in inflammatory markers (IL-6, IL-8, TNF-alpha, hs-CRP) were observed between treatments. Beta-glucan and plant stanols did not influence inflammatory parameters.
Serum lipids and postprandial glucose and insulin levels in hyperlipidemic subjects after consumption of an oat beta-glucan-containing ready meal.
A parallel, placebo-controlled trial in 43 hyperlipidemic subjects tested the effect of a ready meal containing 4 g of oat beta-glucans on cholesterol levels and postprandial glucose and insulin concentrations. The beta-glucan-enriched meal did not significantly lower total or LDL cholesterol compared to control, nor did it affect postprandial glucose or insulin levels.
No effect of added beta-glucan or of fructooligosaccharide on appetite or energy intake.
RCT with 21 healthy volunteers testing the effect of beta-glucan, fructooligosaccharide (FOS), or a combination on appetite ratings and food intake over 2 days. The addition of these substances did not affect appetite ratings or food intake, although beta-glucan increased gastric viscosity.
A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy.
Phase I/II trial of beta-(1,3)/(1,6) D-glucan in 20 patients with advanced malignancies receiving chemotherapy. The study found beta-glucan to be well-tolerated and potentially beneficial for hematopoiesis, suggesting further study, particularly in chronic lymphocytic leukemia and lymphoma.
Effect of muesli with 4 g oat beta-glucan on postprandial blood glucose, gastric emptying and satiety in healthy subjects: a randomized crossover trial.
Randomized crossover trial with 12 healthy subjects evaluating the effect of muesli with 4 g oat beta-glucan on gastric emptying, postprandial blood glucose, and satiety. Oat beta-glucan significantly lowered postprandial glucose response compared to cornflakes, but did not significantly affect gastric emptying rate or satiety.
Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia.
RCT investigating the effect of bread with 6 g of beta-glucan on serum lipids in overweight males with mild hypercholesterolemia. The beta-glucan group showed significant improvements in HDL cholesterol, reductions in LDL and non-HDL cholesterol, and improved total cholesterol/HDL and LDL/HDL ratios compared to the control group.