Research

Barley Grass

22 peer-reviewed studies curated from PubMed and Semantic Scholar.

0
Meta-analyses
0
Systematic reviews
2
RCTs
20
Other studies
RCTs (9%)
Observational (5%)

Studies

Sorted by quality and recency

2025·Frontiers in nutrition·Mingxuan Cui, Lin Shao, Shilong Zhao, et al

Effects of barley green on uric acid, inflammatory factors, xanthine oxidase activity and body composition of patients with hyperuricemia: a randomized controlled trial.

RCTn = 90Inflammation Nutrition

This randomized controlled trial evaluated the efficacy of barley green in reducing uric acid levels and its effects on inflammatory factors, metabolic indices, and body composition in individuals with hyperuricemia. The intervention group receiving barley green showed a greater reduction in uric acid levels, improvements in xanthine oxidase activity, and body composition compared to the control group over a 3-month period.

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2025·Foods (Basel, Switzerland)·Alicja Barańska-Dołomisiewicz, Joanna Żubernik, Katarzyna Samborska, et al

Effects of Spray-Drying Conditions on the Functional and Physicochemical Properties of Young Barley Grass Juice Powders.

Study

The study analyzed the effects of spray-drying conditions on the functional and physicochemical properties of young barley grass juice powders. It found that dehumidified air application enabled the production of carrier-free young barley leaf juice powder with high retention of chlorophyll A and B. The study also noted the highest degradation among bioactive compounds for vitamin C.

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2021·Journal of the science of food and agriculture·Ying Liu, Weifeng Chen, Liuping Fan

Effects of different drying methods on the storage stability of barley grass powder.

ObservationalNutrition

The study evaluated the effects of different drying methods on the storage stability of barley grass powder. Vacuum freeze drying (VFD) preserved color, l-ascorbic acid, and chlorophyll better than hot-air drying (HAD), steam blanching prior to hot-air drying (SHAD), and far-infrared drying (FID). SHAD shortened drying time and delayed degradation of l-ascorbic acid and chlorophyll during storage.

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2002·Diabetes & metabolism·Y-M Yu, W-C Chang, C-T Chang, et al

Effects of young barley leaf extract and antioxidative vitamins on LDL oxidation and free radical scavenging activities in type 2 diabetes.

RCTn = 36Heart Health

RCT evaluating the effects of young barley leaf extract (BL) and/or vitamins C and E on LDL oxidation and free radical scavenging in 36 type 2 diabetic patients. Supplementation reduced blood chemiluminescence levels and increased vitamin E content in LDL subfractions, with the greatest antioxidative effect observed in the BL + CE group.

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2024·Biologia futura·Ferenc Lantos, Vivien Váczi, Ingrid Gyalai, et al

Investigation of in vitro biological activity of young Hordeum vulgare leaf in correlation with its bioactive compounds.

In vitroInflammation

The study examined the chemical characteristics and antioxidant activity of Hordeum vulgare methanolic and aqueous extracts. The methanolic extract showed potent antioxidant activity and moderate inhibition of xanthine oxidase, suggesting potential health benefits. The study highlights the importance of harvest timing and extraction methods on the phytochemical composition and pharmacological activity of H. vulgare.

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2024·Anti-inflammatory & anti-allergy agents in medicinal chemistry·Revathi Boyina, Sreya Kosanam, Sasidhar Bhimana, et al

andAssessment of Anti-inflammation Properties of Saponarin Extracted from Hordeum Vulgare.

In vitroInflammation

The study investigates the anti-inflammatory properties of saponarin extracted from Hordeum vulgare (Barley grass). Both Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ) showed significant inhibitory effects on inflammation, with BGHE exhibiting superior efficacy.

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2022·Nutrition and cancer·Jing Li, Wen Zhang, Hongwei Xu, et al

Barley Grass Juice Attenuates Hydrodynamic Transfection-Induced HCC Initiation in Mice.

Animal studyImmunity Inflammation

The study investigated the effects of barley grass juice on hepatocellular carcinoma (HCC) in a mouse model. Barley grass juice administration attenuated tumor development and increased immune cell infiltration in the liver, suggesting potential benefits for HCC alleviation.

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2022·Animals : an open access journal from MDPI·Marian Burducea, Ivayla Dincheva, Lenuta Dirvariu, et al

Wheat and Barley Grass Juice Addition to a Plant-Based Feed Improved Growth and Flesh Quality of Common Carp ().

Animal studyNutrition

The study assessed the effect of wheat grass juice and barley grass juice addition to fish diet on growth and meat quality of common carp. The inclusion of these juices in the plant-based feed stimulated growth and improved meat quality by lowering fat and ash content, with no significant effect on feed conversion ratio and condition factor.

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2021·Antioxidants (Basel, Switzerland)·Krystyna Joanna Gromkowska-Kępka, Renata Markiewicz-Żukowska, Patryk Nowakowski, et al

Chemical Composition and Protective Effect of Young Barley (L.) Dietary Supplements Extracts on UV-Treated Human Skin Fibroblasts in In Vitro Studies.

In vitroSkin Hair Health

In vitro study evaluating the effect of young barley extracts on human skin fibroblasts exposed to UVB radiation. Young barley extract increased fibroblast survival, accelerated migration, and inhibited MMP-2 and MMP-9 expression, suggesting protective and restorative effects for potential use in nutricosmetics.

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2021·Journal of agricultural and food chemistry·Manh Tuan Ha, Phuong Thao Tran, Huynh Nguyen Khanh Tran, et al

Anti-osteoclastogenic Effects of Indole Alkaloids Isolated from Barley (Var.) Grass.

Animal studyJoint Bone Health

The study investigated the anti-osteoclastogenic effects of indole alkaloids isolated from barley grass (HVA). The alkaloid fraction significantly inhibited RANKL-induced osteoclast formation and protected mice from LPS-induced bone loss, suggesting potential for preventing and treating osteolytic bone diseases.

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2021·Microbiome·Daotong Li, Yu Feng, Meiling Tian, et al

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Animal studyGut Health Inflammation

The study investigates the effects of dietary barley leaf supplementation on colitis, focusing on gut microbiota-derived inosine and PPARγ signaling activation. Barley leaf supplementation ameliorated DSS-induced gut microbiota dysbiosis and improved intestinal mucosal barrier functions, suggesting a protective role against colitis.

Semantic ScholarRead on Semantic Scholar
2020·BMC complementary medicine and therapies·Mamata Panthi, Romit Kumar Subba, Bechan Raut, et al

Bioactivity evaluations of leaf extract fractions from young barley grass and correlation with their phytochemical profiles.

In vitroInflammation Immunity

The study evaluated the bioactivity of leaf extract fractions from young barley grass, focusing on their antioxidant and anti-inflammatory properties. The extracts showed high phenolic and flavonoid contents, correlating with strong antioxidant activity. Methanolic and ethyl acetate extracts demonstrated significant anti-inflammatory activity, and the Brine Shrimp Lethality Assay indicated bioactivity, suggesting potential as plant-derived anti-tumor compounds.

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2017·Ultrasonics sonochemistry·Xiaohuang Cao, Min Zhang, Arun S Mujumdar, et al

Effects of ultrasonic pretreatments on quality, energy consumption and sterilization of barley grass in freeze drying.

StudyNutrition

The study investigates the effects of ultrasonic pretreatments on the quality, energy consumption, and sterilization of barley grass during freeze drying. Ultrasonic treatments at various power levels improved drying efficiency, reduced energy consumption, and enhanced the nutritional quality of barley grass by increasing flavonoid and chlorophyll content.

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2017·Journal of the science of food and agriculture·Xiaohuang Cao, Min Zhang, Arun S Mujumdar, et al

Effect of microwave freeze drying on quality and energy supply in drying of barley grass.

Study

The study investigates the effect of microwave freeze drying on the quality and energy efficiency of drying barley grass. It found that microwave freeze drying retains chlorophyll and flavonoids, improves color and odor, and decreases energy consumption compared to contact heating.

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2013·Evidence-based complementary and alternative medicine : eCAM·Akira Takano, Tomoyasu Kamiya, Hiroshi Tomozawa, et al

Insoluble fiber in young barley leaf suppresses the increment of postprandial blood glucose level by increasing the digesta viscosity.

StudyNutrition

The study examined the effects of barley leaf powder (BLP) and its insoluble fibers on postprandial blood glucose levels in rats and healthy Japanese volunteers. BLP and its insoluble fibers suppressed the increment of postprandial blood glucose levels in rats and increased digesta viscosity. In humans, BLP suppressed postprandial blood glucose levels in individuals with higher blood glucose levels after meals.

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2019·Journal of ethnopharmacology·Jhansyrani Thatiparthi, Sujatha Dodoala, Bharathi Koganti, et al

Barley grass juice (Hordeum vulgare L.) inhibits obesity and improves lipid profile in high fat diet-induced rat model.

Animal studyPhysique Heart Health

The study evaluated the anti-obesity activity of barley grass juice in a high fat diet-induced rat model. Barley grass juice administration for 60 days decreased body weight, improved lipid profile, and liver function markers, and reduced atherosclerosis in rats. GC-MS analysis identified 12 phytochemical constituents in the juice.

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2019·Annals of agricultural and environmental medicine : AAEM·Katarzyna Kawka, Marta Kinga Lemieszek, Wojciech Rzeski

Chemopreventive properties of young green barley extracts in in vitro model of colon cancer.

In vitroInflammation Longevity

In vitro study of young green barley extracts on colon cancer cell lines. The extracts significantly inhibited proliferation of colon cancer cells without affecting normal colon epithelial cells, suggesting potential for colon cancer chemoprevention.

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2017·Annals of agricultural and environmental medicine : AAEM·Arkadiusz Czerwonka, Katarzyna Kawka, Klaudia Cykier, et al

Evaluation of anticancer activity of water and juice extracts of young Hordeum vulgare in human cancer cell lines HT-29 and A549.

In vitro

In vitro study evaluating the anticancer activity of water and juice extracts of young Hordeum vulgare (barley) in human cancer cell lines HT-29 and A549. The extracts inhibited proliferation of cancer cells, with dose-dependent cytotoxicity against HT-29 cells. Free radical scavenging activity was observed in the water extract.

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2016·Nutrition and cancer·Peter Kubatka, Martin Kello, Karol Kajo, et al

Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro.

Animal studyInflammation

The study evaluated the antitumor effects of dietary young barley in female rats for the prevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis. Barley demonstrated a mild antitumor effect, with increased caspase-3 expression and reduced Ki67 expression in rat tumor cells. In vitro studies showed barley decreased survival of MCF-7 breast cancer cells and prevented cell cycle progression.

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2018·Oxidative medicine and cellular longevity·Yawen Zeng, Xiaoying Pu, Jiazhen Yang, et al

Preventive and Therapeutic Role of Functional Ingredients of Barley Grass for Chronic Diseases in Human Beings.

ReviewSleep Immunity Gut Health Inflammation Heart Health Brain Health Skin Hair Health Longevity Nutrition

Narrative review of the functional ingredients of barley grass and their preventive and therapeutic roles for chronic diseases. Barley grass is rich in ingredients like GABA, flavonoids, and vitamins, promoting sleep, enhancing immunity, protecting the liver, and having anti-inflammatory and antioxidant effects.

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2015·The American journal of Chinese medicine·Lamia Lahouar, Safia El-Bok, Lotfi Achour

Therapeutic Potential of Young Green Barley Leaves in Prevention and Treatment of Chronic Diseases: An Overview.

Review

This narrative review discusses the therapeutic potential of barley grass (young green barley leaves) in the prevention and treatment of chronic diseases. It highlights the pharmacological activities of barley grass, including anticancer, antioxidant, and anti-inflammatory effects, and its potential benefits for blood flow, digestion, and detoxification.

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2019·The Journal of dermatology·Natsuko Utsunomiya, Noritaka Oyama, Takenao Chino, et al

Dietary supplement product composed of natural ingredients as a suspected cause of erythema multiforme: A case report and identification for the confident false positivity of lymphocyte transformation test.

Case reportn = 22

Case report of a Japanese elderly man developing erythema multiforme after intake of a dietary supplement containing Euglena and other natural ingredients. The lymphocyte transformation test (LTT) showed high positivity, suggesting unreliability for diagnosing adverse skin reactions to such products.

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