Research
Bacopa Monnieri
10 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Improvement of Executive Function after Short-Term Administration of an Antioxidants Mix Containing Bacopa, Lycopene, Astaxanthin and Vitamin B12: The BLAtwelve Study.
RCT evaluating the effects of an antioxidant mix containing bacopa, lycopene, astaxanthin, and vitamin B12 on cognitive function in 80 healthy older adults. The active group showed significant improvements in TMT scores and verbal fluency compared to placebo, suggesting potential benefits for brain health.
The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials.
Systematic review of randomized controlled trials examining Bacopa monnieri's effects on cognitive performance in humans. Bacopa improved performance on 9 of 17 memory free recall tests, with little evidence of enhancement in other cognitive domains.
Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with ‘Optimal’ and ‘Sub-Optimal’ Diets: A Randomized Double Blind Placebo Controlled Trial
RCT evaluating a multinutrient formula containing B group vitamins, Bacopa monniera, and Ginkgo biloba on memory, attention, mood, and biochemical markers in middle-aged adults with varying diet quality over 12 weeks. Significant increases in B vitamin status were observed, with a beneficial effect on attentional performance in individuals with an 'optimal' diet, but no significant benefit to memory or attention in the whole cohort.
Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial.
Double-blind placebo-controlled RCT with 107 healthy participants, 62 completing with 80% compliance, testing Bacopa monniera extract (KeenMind) over 90 days. Bacopa monniera significantly improved spatial working memory accuracy and reduced false-positives in cognitive tasks.
The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.
Double-blind placebo-controlled RCT examining the chronic effects of Bacopa monniera (300 mg) on cognitive function in healthy humans. B. monniera significantly improved speed of visual information processing, learning rate, memory consolidation, and reduced state anxiety compared to placebo, with maximal effects after 12 weeks.
Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study.
This double-blind, placebo-controlled study assessed the effects of a multi-ingredient herbal supplement containing Bacopa, American ginseng, and whole coffee fruit extract on cognitive performance and cerebral-cortical activation. In 40 healthy adults, the supplement improved working memory task performance and reduced prefrontal cortex activation, indicating increased neural efficiency.
Safety evaluation of BacoMind in healthy volunteers: a phase I study.
Phase I study evaluating the safety and tolerability of BacoMind, an enriched phytochemical composition of Bacopa monniera, in 23 healthy adult volunteers. Participants received 300 mg for the first 15 days and 450 mg for the next 15 days. No significant adverse effects were observed, though mild gastrointestinal events were noted.
Engineering Bacopa monnieri for improved bacoside content and its neurological evaluation
The study engineered Bacopa monnieri to enhance bacoside content by over-expressing squalene synthase and silencing a competitive pathway. The enhanced extract showed improved efficacy in locomotor activity, neuromuscular coordination, and social interaction in a rat model of Parkinson's disease, suggesting potential benefits for neurological disorders.
Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review)
Narrative review evaluating the pharmacological effects and therapeutic potential of Bacopa monnieri compounds. The review highlights cognitive enhancement effects, non-toxicity, and potential applications in treating cognitive impairments, depression, and neurodegenerative diseases.
Mechanisms, Efficacy, and Safety of Bacopa monnieri (Brahmi) for Cognitive and Brain Enhancement
The paper reviews the mechanisms, efficacy, and safety of Bacopa monnieri (Brahmi) for cognitive and brain enhancement. It discusses the plant's historical use in Ayurveda and its potential benefits in improving memory and cognitive function, highlighting various mechanisms such as anti-inflammatory and antioxidant effects. The paper emphasizes the need for larger clinical trials to further explore its effects on cognitive decline and Alzheimer's disease.