Research
B-Complex
10 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Assessment of vitamin A, vitamin B, vitamin B, vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial.
The MultiVeg study, a double-blind RCT, assessed the nutritional status of 72 healthy vegans following 4 months of multinutrient supplementation. Significant positive effects were observed on vitamin B blood biomarkers, while no significant changes were noted for other vitamins and choline.
A Randomized Control Trial of Dexketoprofen/Vitamin B (Thiamine, Pyridoxine and Cyanocobalamin) Fixed-Dose Combination in Post-Traumatic Grade I-II Cervical Sprains.
A multicentre, prospective, randomized, double-blind, phase IIIb clinical study comparing dexketoprofen/vitamin B (thiamine, pyridoxine, cyanocobalamin) fixed-dose combination (FDC) versus dexketoprofen monotherapy for acute pain in grade I-II cervical sprains. The FDC showed superior efficacy and a better safety profile, with significant reduction in pain intensity and disability.
Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome.
Prospective, partially randomized study evaluating the efficacy of an antioxidant combination (lipoic acid, acetylcysteine, vitamin B, adenosyl-L-methionine) in non-diabetic women with PCOS. The antioxidant group showed a significant reduction in HOMA-IR levels, and all groups showed improvements in hirsutism, acne, irregular menstruation, and quality of life.
Photobiomodulation, Transmucosal Laser Irradiation of Blood, or B complex as alternatives to treat Covid-19 Related Long-Term Taste Impairment: double-blind randomized clinical trial.
Double-blind randomized clinical trial assessing treatments for COVID-19 Related Long-Term Taste Impairment (CRLTTI) using Photobiomodulation, Transmucosal Laser Irradiation of Blood, and B complex supplementation. No intergroup statistical differences were observed, though PBM and TLIB showed tendencies for better results. B complex supplementation was tested for 30 days.
Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases.
Meta-analysis evaluated the efficacy of folic acid along with vitamin B12 and/or B6 in lowering homocysteine and attenuating cognitive decline in elderly patients with Alzheimer's disease or dementia. The intervention group achieved a significant reduction in homocysteine levels, but no significant difference in cognitive improvement was observed.
Investigation of the efficacy of two different laser types in the treatment of lower lip paresthesia after sagittal split ramus osteotomy.
This randomized controlled trial investigated the effectiveness of two different laser types and vitamin B in treating lower lip paresthesia after bilateral sagittal split ramus osteotomy. Thirty patients were divided into three groups: GRR laser, Epic10 laser, and vitamin B. Both vitamin B and laser therapies accelerated nerve regeneration, with laser groups showing better healing rates than the vitamin B group.
Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial.
RCT of 51 inpatients with major depressive disorder testing adjuvant thiamine versus placebo alongside SSRI treatment. Thiamine improved symptoms of depression after 6 weeks, with improvements remaining stable until the end of the study, though not statistically significant at week 12.
Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins.
RCT assessing the effects of hydrosoluble vitamin supplementation on serum homocysteine levels in 168 hemodialysis patients. Supplementation with B-complex vitamins significantly reduced homocysteine levels over 12 months, with additional intravenous folic acid showing a more pronounced effect in certain genotypes.
Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer's Disease.
RCT assessing the influence of vitamin B supplementation on oxidative stress, inflammation, and cognition in patients with Alzheimer's disease and mild cognitive impairment. Vitamin supplementation led to reduced levels of carbonyl proteins and a higher MMSE score, though the latter did not reach significance.
Vitamin B Blood Plasma Deficiency Model for the Study of Diabetes Complications Demonstrates Potential for the Cure and Prevention of Complications in Type 2 Diabetes Mellitus Patients
Open trial started in 2008 with type 2 diabetes mellitus patients using a vitamin B supplement containing nicotinamide, thiamine hydrochloride, and calcium-d-pantothenate. Reported cures of early-stage diabetes complications affecting the eye, kidney, and skin, with prevention of symptom reappearance for over 6 years.