Research
Astragalus
135 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Astragalus membranaceus Extract as a Botanical Ingredient for Pigmentary and Anti-Aging Skincare: A Systematic Review.
This systematic review investigates the anti-aging potential of Astragalus membranaceus, focusing on its active components and their roles in dermal protection, antioxidant, anti-inflammatory, and anti-aging properties. Bioactive compounds showed photoprotective effects, including ROS reduction, inflammatory signaling inhibition, and promotion of collagen synthesis. Clinical trials indicated improvements in skin hydration, tone, and wrinkle reduction.
Effect of Astragalus injection treatment for viral myocarditis: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effectiveness of Astragalus injection in treating viral myocarditis. The analysis included 26 studies with 2793 patients, showing that Astragalus injection significantly improved effectiveness rates and reduced levels of AST, CK, CK-MB, LDH, and cTnI compared to standard treatment.
Efficacy and safety of astragalus polysaccharides in patients with malignant tumors: A systematic review and meta-analysis.
Systematic review and meta-analysis of 31 RCTs involving 2,648 participants evaluating the efficacy and safety of Astragalus polysaccharide (APS) in malignant tumor patients. APS supplementation improved treatment efficacy, enhanced immune function, and showed a high safety profile, making it a promising option for clinical use.
Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation
Meta-analysis of 15 studies involving 1,443 patients with diabetic nephropathy treated with Astragalus and Salvia miltiorrhiza. The combination improved clinical outcomes and renal function, with a significant reduction in fasting blood glucose levels after 12 weeks. Network pharmacology and molecular docking suggest interactions with PI3K/Akt, MAPK, and NF-kappa B pathways, and in vivo experiments confirmed improvements in renal function and iron metabolism.
Intervention of Astragalus Membranaceus Extract in rats of spinal cord injury: a systematic review and meta-analysis.
Systematic review and meta-analysis of 16 studies with 996 animals examining the effects of Astragalus Membranaceus Extract (AME) on spinal cord injury. AME administration was associated with significant functional recovery, particularly with doses over 20 units and treatment durations under 14 days.
Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies.
Systematic review and meta-analysis of 9 RCTs involving 776 patients with cervical cancer. Astragalus polysaccharides combined with chemoradiotherapy improved objective response rate, disease control rate, and Karnofsky Performance Status score. It also enhanced immune function and reduced tumor marker levels compared to chemoradiotherapy alone.
Effects of TA-65 on telomere length, functional outcomes, and inflammation: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated 8 RCTs with 750 participants on the effects of TA-65, a telomerase-activating compound from Astragalus membranaceus, on telomere length, functional aging, and inflammation. TA-65 induced moderate telomere elongation, especially in adults over 60, but did not improve frailty or inflammation metrics. Mild gastrointestinal toxicity was noted, with no severe adverse events over 12 months.
Efficacy of Astragalus Membranaceus (Huang Qi) for Cancer-Related Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.
Systematic review and meta-analysis of randomized controlled trials assessing the efficacy of Astragalus membranaceus for cancer-related fatigue and quality of life in cancer patients. The meta-analysis found that Astragalus membranaceus was effective in reducing cancer-related fatigue and improving quality of life, though the evidence is limited by the small and low quality of included studies.
Astragalus in Acute Pancreatitis: Insights from Network Pharmacology, Molecular Docking, and Meta-Analysis Validation
The study investigates the therapeutic effects of Astragalus in acute pancreatitis (AP) using network pharmacology, molecular docking, and meta-analysis. It identifies active compounds and molecular mechanisms, with a meta-analysis of six RCTs showing higher clinical efficacy in the Astragalus group compared to control.
Efficacy of astragalus combined with renin-angiotensin-aldosterone system blockers in the treatment of stage III diabetic nephropathy: a systematic review and meta-analysis.
Systematic review and meta-analysis of 32 papers involving 2462 patients with stage III diabetic nephropathy. The study evaluated the efficacy of Astragalus combined with RAAS blockers, showing improved total effective rate and reduced urinary protein excretion, serum creatinine, blood urine nitrogen, and glycosylated hemoglobin levels. The combination treatment was found to be safe, but further rigorous trials are recommended.
Renal protective effects and mechanisms of Astragalus membranaceus for diabetic kidney disease in animal models: An updated systematic review and meta-analysis.
This systematic review and meta-analysis synthesized the effects and mechanisms of Astragalus membranaceus on renal outcomes in diabetic kidney disease animal models. AM treatment significantly decreased serum creatinine, blood urea nitrogen, urinary albumin excretion rate, and histological changes, while improving anti-oxidative stress expression and decreasing inflammation and fibrosis markers.
Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta-analysis.
Systematic review and meta-analysis of seven RCTs involving 1256 patients evaluating the TCM combination of Jie Geng and Huang Qi in reducing postoperative wound infections (PWIs) in colorectal cancer surgeries. The TCM-treated group showed a significant reduction in PWI incidence, hospital stay, and antibiotic use compared to controls.
Effect of astragalus injection on left ventricular remodeling in HFmrEF: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effect of astragalus injection on left ventricular remodeling in patients with heart failure with mildly reduced ejection fraction. The analysis of 10 RCTs with 995 patients showed that astragalus injection significantly improved left ventricular ejection fraction and reduced various ventricular volumes and diameters compared to conventional treatment, without increasing adverse reactions.
Astragalus membranaceus formula for moderate-high risk idiopathic membranous nephropathy: A meta-analysis.
Meta-analysis of 50 studies involving 3423 participants evaluating Astragalus membranaceus combined with supportive care or immunosuppressive therapy for moderate-high risk idiopathic membranous nephropathy. The combination improved 24-hour urinary total protein, serum albumin, serum creatinine, and remission rates compared to supportive care or immunosuppressive therapy alone.
The Effect of Astragalus on Humoral and Cellular Immune Response: A Systematic Review and Meta-Analysis of Human Studies.
This systematic review and meta-analysis evaluated the effect of Astragalus on humoral and cellular immune response in human studies. The analysis included 19 studies with 1,094 participants, showing a significant reduction in proinflammatory cytokines and an increase in cellular immune markers, suggesting Astragalus's potential as a therapeutic agent for immune-related disorders.
The combination of astragalus injection and ambroxol hydrochloride in the adjuvant treatment of COPD: a systematic review and meta-analysis.
Systematic review and meta-analysis of 14 randomized controlled trials involving 1070 patients with COPD. The study assessed the efficacy of combining astragalus injection with ambroxol hydrochloride as an adjuvant treatment, finding improvements in various clinical parameters compared to conventional treatment alone.
The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
This meta-analysis evaluated the effects of Astragalus as an adjuvant treatment for type 2 diabetes mellitus, encompassing 20 studies with 953 participants. Astragalus treatment showed improvements in fasting plasma glucose, 2-hour postprandial plasma glucose, glycated hemoglobin A1C, and insulin sensitivity compared to control. However, the certainty of evidence and risk of bias were suboptimal, suggesting the need for further research.
Meta-analysis of Huangqi (Astragalus membranaceus) and Chinese Yam (Rhizoma Dioscoreae) for Diabetic Nephropathy.
Meta-analysis evaluating the combination of Astragalus membranaceus and Rhizoma Dioscoreae with Western medicine for diabetic nephropathy. The intervention groups showed a significantly greater reduction in 24-hour urinary protein compared to control groups, indicating the combination's efficacy in reducing proteinuria.
Efficacy of astragalus in the treatment of radiation-induced lung injury based on traditional Chinese medicine: A systematic review and meta-analysis of 25 RCTs.
Systematic review and meta-analysis of 25 RCTs evaluating the efficacy of astragalus in treating radiation-induced lung injury (RILI). Astragalus-containing preparations significantly reduced the incidence of RILI, improved patient quality of life, alleviated breathing difficulties, and reduced inflammatory factors without reported adverse reactions.
Efficacy of Huangqi Injection in the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 15 studies with 1,483 participants evaluating Huangqi injection (Astragalus membranaceus) combined with antihypertensive drugs for hypertensive nephropathy. HQI showed better efficacy than antihypertensive drugs alone in reducing 24-h urinary total protein, microalbuminuria, serum creatinine, blood pressure, cystatin-C, and blood urea nitrogen.
Effect of kangai injection combined with platinum-based chemotherapy on the immune function of patients with advanced non-small-cell lung cancer: A meta-analysis.
Meta-analysis of 19 RCTs with 1,389 cases evaluating Kangai injection combined with platinum-based chemotherapy in advanced NSCLC patients. The combination improved objective response rate, disease control rate, Karnofsky performance status, and immune function, while reducing chemotherapy toxicity compared to chemotherapy alone.
Pharmacological mechanism and clinical study of Qiming granules in treating diabetic retinopathy based on network pharmacology and literature review.
This systematic review analyzes the pharmacological mechanism and clinical effectiveness of Qiming granules in treating diabetic retinopathy. The study uses network pharmacology and literature review to confirm that Qiming granules act through multiple components, targets, and channels.
Network pharmacology-based identification of miRNA expression of Astragalus membranaceus in the treatment of diabetic nephropathy.
This systematic review uses network pharmacology to identify the active ingredients and potential pharmacological mechanisms of Astragalus membranaceus in treating diabetic nephropathy. The study identifies 17 active ingredients and 214 target proteins, highlighting pathways involved in inflammatory response, angiogenesis, and oxidative stress.
Database mining and animal experiment-based validation of the efficacy and mechanism of Radix Astragali (Huangqi) and Rhizoma Atractylodis Macrocephalae (Baizhu) as core drugs of Traditional Chinese medicine in cancer-related fatigue.
Meta-analysis of 24 RCTs involving 1865 patients showed that Traditional Chinese Medicine (TCM), specifically Radix astragali and Rhizoma atractylodis macrocephalae, produced more positive effects on cancer-related fatigue (CRF) than standard therapy alone. Animal experiments confirmed these TCMs enhanced physical fitness, reduced inflammatory factors, and affected tumor weight and metabolic pathways.
A systematic review on Zhilong Huoxue Tongyu capsule in treating cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms and clinical outcomes.
This systematic review examines the pharmacological actions, molecular mechanisms, and clinical outcomes of Zhilong Huoxue Tongyu capsule in treating cardiovascular and cerebrovascular diseases. The review highlights the capsule's anti-inflammatory, anti-apoptosis, and angiogenesis-promoting effects, benefiting over 1000 clinical cases.
Clinical and Preclinical Systematic Review of Astragalus Membranaceus for Viral Myocarditis.
Systematic review of 28 randomized clinical control studies with 2522 participants and 16 animal studies with 634 animals evaluating Astragalus membranaceus for viral myocarditis. AM significantly reduced serum myocardial enzymes and cardiac troponin I levels, improved clinical treatment efficiency, and increased survival rate in animal studies. Mechanisms include antivirus, anti-inflammatory, antioxidation, antiapoptotic, antifibrosis, and reducing cardiac calcium load.
A review on the chemical profiles, quality control, pharmacokinetic and pharmacological properties of Fufang Xueshuantong Capsule.
This systematic review analyzes the chemical profiles, quality control, pharmacokinetic, and pharmacological properties of Fufang Xueshuantong Capsule (FXC), a traditional Chinese medicine formula. It highlights the need for improved quality control, comprehensive pharmacokinetic studies, and in-depth pharmacological mechanism research.
Astragalus membranaceus (Huang Qi) as adjunctive therapy for diabetic kidney disease: An updated systematic review and meta-analysis.
This updated systematic review and meta-analysis evaluated the efficacy and safety of Astragalus membranaceus as adjunctive therapy for diabetic kidney disease (DKD). The analysis included 66 studies with 4785 participants, showing that A. membranaceus reduced albuminuria, proteinuria, and serum creatinine levels more than conventional therapies alone. However, the quality of evidence was low, and further high-quality RCTs are needed.
Evidence of Astragalus injection combined platinum-based chemotherapy in advanced nonsmall cell lung cancer patients: A systematic review and meta-analysis.
Systematic review and meta-analysis of 19 RCTs with 1635 patients evaluating Astragalus injection combined with platinum-based chemotherapy in advanced NSCLC. The combination improved objective response rate, Karnofsky performance status, 1-year survival rate, and immune cell percentages, while reducing leukopenia, platelet toxicity, and vomiting. Evidence quality was low.
Meta-Analysis of Astragalus-Containing Traditional Chinese Medicine Combined With Chemotherapy for Colorectal Cancer: Efficacy and Safety to Tumor Response.
This meta-analysis evaluated the safety and efficacy of Astragalus-based Chinese medicines combined with chemotherapy versus chemotherapy alone for colorectal cancer treatment. It included 22 studies with 1,409 subjects and found that the combination may increase tumor response rate, improve life quality, and reduce adverse reactions compared to chemotherapy alone.
Adjuvant therapy with Astragalus membranaceus for post-stroke fatigue: a systematic review.
Systematic review of 16 RCTs with 1222 participants assessing the efficacy of Astragalus membranaceus (Huangqi) as adjuvant therapy for post-stroke fatigue. Treatment with CHM-HQ decreased fatigue severity and improved quality of life, though evidence quality was poor with unclear or high risks of bias.
Clinical efficacy and safety of Aidi injection plus paclitaxel-based chemotherapy for advanced non-small cell lung cancer: A meta-analysis of 31 randomized controlled trials following the PRISMA guidelines.
Meta-analysis of 31 RCTs involving 2058 patients with advanced non-small cell lung cancer, assessing Aidi injection plus paclitaxel-based chemotherapy. Aidi injection improved objective response rate, disease control rate, and quality of life, while reducing hematotoxicity, gastrointestinal toxicity, and liver injury compared to chemotherapy alone.
The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis.
Meta-analysis of 13 studies with 1054 participants evaluating Astragalus as an adjuvant treatment for type 2 diabetes mellitus. Astragalus administration significantly reduced fasting and postprandial plasma glucose, fasting insulin, and HOMA-IRI levels, with mixed results on glycated hemoglobin A1c levels. Further high-quality studies are needed.
Oral Chinese herbal medicine combined with pharmacotherapy for stable COPD: a systematic review of effect on BODE index and six minute walk test.
Systematic review of 25 RCTs evaluating Chinese herbal medicine (CHM) plus routine pharmacotherapy (RP) on BODE index and 6-minute walk test in stable COPD patients. Meta-analysis showed benefits for BODE Index and 6MWT/D in favor of CHM plus RP groups. Principal herbs included Astragalus membranaceus, Panax ginseng, and Cordyceps sinensis. Methodological weaknesses were noted.
Astragalus (a traditional Chinese medicine) for treating chronic kidney disease.
This meta-analysis evaluated the effects of Astragalus on chronic kidney disease, including 22 studies with 1323 participants. Astragalus showed mixed effects, significantly increasing CrCl, decreasing SCr, reducing proteinuria, and increasing haemoglobin and serum albumin levels. However, the study quality was low, and definitive conclusions could not be made.
Astragalus membranaceus injection combined with conventional treatment for viral myocarditis: a systematic review of randomized controlled trials.
Systematic review and meta-analysis of six RCTs involving 639 participants assessing Astragalus membranaceus Injection combined with conventional therapy for viral myocarditis. The combination treatment showed a higher total effective rate and significant recovery in myocardium enzyme levels and electrocardiography compared to conventional treatment alone. However, the methodological quality was low, and there was a high risk of publication bias.
The clinical value of Huangqi injection in the treatment of leucopenia: a meta-analysis of clinical controlled trials.
Meta-analysis of 13 studies involving 841 patients assessing the clinical value of Huangqi injection for treating leucopenia. The analysis showed greater therapeutic efficacy and lower white blood cell counts in patients treated with Huangqi compared to those treated with Western medicine, though study quality was generally low.
Interventions for preventing infection in nephrotic syndrome.
Meta-analysis of 12 studies involving 762 children with nephrotic syndrome in China. The studies assessed various prophylactic interventions, including IVIG, thymosin, oral transfer factor, BCG vaccine, Huangqi granules, and TIAOJINING, for preventing infection. IVIG, thymosin, oral transfer factor, BCG vaccine, Huangqi granules, and TIAOJINING showed positive effects on infection prevention, but the methodological quality was poor.
Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy.
Meta-analysis of 25 studies, including 21 RCTs and 4 CCTs, involving 1804 patients with diabetic nephropathy. Astragalus membranaceus showed significant renal protective effects and systemic state improvement compared to control.
Efficacy and safety of medicine-food homology Shenqi paste in older adults with diabetic sarcopenia: A randomized, double-blind, placebo-controlled trial.
RCT of 90 older adults with diabetic sarcopenia comparing Shenqi paste to placebo for 12 weeks. The SQP group showed significant improvements in muscle mass, strength, function, and metabolic and inflammatory profiles, with good tolerability.
Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial.
This multi-center, assessor-blind RCT evaluated the effect of add-on astragalus on kidney function in 118 patients with type 2 diabetes and CKD. Over 48 weeks, astragalus slowed the decline in eGFR compared to standard care, though changes in UACR were not significant. Astragalus also lowered systolic blood pressure.
Safety of the Herbal Medicine SH003 in Patients With Solid Cancer: A Multi-Center, Single-Arm, Open-Label, Dose-Escalation Phase I Study.
Phase I trial evaluating the safety of SH003, a herbal medicine comprising Huang-Qi, Dang-Gui, and Gua-Lou-Gen, in patients with solid cancers. The study established the maximum tolerated dose as 9600 mg/day, with most adverse events being mild, indicating tolerability.
A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections.
RCT comparing a D-mannose-based dietary supplement (DAPAD complex) to placebo for treating uncomplicated E. coli UTIs in nonmenopausal women. The DAPAD group showed higher clinical and bacteriological resolution rates at day 6 and day 35 compared to placebo, with no moderate or severe symptoms reported in the DAPAD group at day 35.
The clinical efficacy and safety of the Chinese herbal medicine Astragalus (Huangqi) preparation for the treatment of acute myocardial infarction: A systematic review of randomized controlled trials.
Systematic review of randomized controlled trials evaluating the efficacy and safety of Astragalus (Huangqi) preparation in the treatment of acute myocardial infarction (AMI). The study aims to provide evidence for clinical practice by analyzing outcomes such as left ventricular function, recanalization rate, mortality, and incidence of arrhythmias.
Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children.
Systematic review assessing the effectiveness and safety of oral Astragalus for preventing frequent episodes of acute respiratory tract infections in children. No RCTs met the inclusion criteria, resulting in insufficient evidence to assess Astragalus's effectiveness and safety.
Biological active ingredients of traditional Chinese herb Astragalus membranaceus on treatment of diabetes: a systematic review.
Systematic review of Astragalus membranaceus, a traditional Chinese herb, focusing on its anti-diabetic compounds such as polysaccharides, saponins, and flavonoids. The review discusses its pharmacological action and potential in treating diabetes mellitus and related complications.
Systematic review of the renal protective effect of Astragalus membranaceus (root) on diabetic nephropathy in animal models.
Systematic review assessing the efficacy and safety of Astragalus membranaceus (root) in slowing the progression of diabetic nephropathy in diabetic rat models. Significant beneficial effects were observed in AM-treated groups regarding fasting blood glucose levels, glomerular filtration rate, urinary albumin excretion rate, and thickness of the glomerular basement membrane.
Chinese medical herbs for chemotherapy side effects in colorectal cancer patients.
Meta-analysis of four trials assessing the effect of Huangqi compounds with chemotherapy in colorectal cancer patients. Results suggest a reduction in nausea, vomiting, and leucopenia, and an increase in T-lymphocyte subsets, though studies were of low quality.
A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study.
A randomized, double-blind, placebo-controlled trial over six months compared the effects of an Astragalus-based supplement versus placebo on telomere length in 40 healthy volunteers. The supplement group exhibited significantly longer median and short telomeres, with increased telomerase activity and reduced percentage of short telomeres, suggesting potential benefits for promoting health and supporting healthy aging.
Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial.
This double-blind RCT involved 18 members of the Polish Rowing Team to assess the effects of Astragalus Membranaceus Root supplementation on immune response to maximal physical exertion. The supplemented group showed stabilization of NK and Treg cells and an increase in Tδγ counts, with modulation of IL2 levels, suggesting a restoration of immunological balance.
Effects of Astragalus Extract Mixture HT042 on Height Growth in Children with Mild Short Stature: A Multicenter Randomized Controlled Trial.
A multicenter, randomized, double-blind, placebo-controlled trial evaluated the effects of HT042, an astragalus extract mixture, on height growth in 129 children with mild short stature. The HT042 group showed significantly higher height gain compared to placebo after 24 weeks, particularly in children below the 10th percentile. The study suggests HT042 may aid height growth without advancing skeletal maturation, potentially mediated by increased serum IGF-1 and IGFBP-3 levels.
PG2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study.
Double-blind, randomized, placebo-controlled study investigating the effect of PG2, an infusible polysaccharide from Astragalus membranaceus, on patients with acute spontaneous intracerebral hemorrhage. No significant differences were found in Glasgow outcome scale or modified Rankin scale scores between treatment and control groups, nor in inflammatory markers.
Effects of Astragalus membranaceus, Codonopsis pilosula and allicin mixture on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs.
A 12-week trial with 120 pigs evaluated the effects of Astragalus membranaceus, Codonopsis pilosula, and allicin mixture supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response, and meat quality. The supplementation improved growth performance, nutrient digestibility, intestinal microbial balance, immune response, and meat quality.
A Randomized Controlled Study to Observe the Efficacy of External Treatment With a Traditional Chinese Medicine Herbal Ointment on Malignant Plural Effusion: Outcome Report and Design Review.
This placebo-controlled double-blinded randomized study evaluated the efficacy of Kang'ai Xiaoshui ointment, a TCM herbal ointment, on malignant pleural effusion (MPE) in 72 patients. The treatment group showed improvement in symptoms such as chest distress, fullness, and shortness of breath compared to placebo. The response rate was higher in the treatment group, though not statistically significant. Skin irritation was the main adverse event.
Effects of the traditional Chinese herb Astragalus membranaceus in patients with poststroke fatigue: A double-blind, randomized, controlled preliminary study.
Double-blind, randomized, controlled preliminary study of Astragalus membranaceus in 64 patients with poststroke fatigue. The treatment group showed significant improvements in fatigue, cognitive functioning, social functioning, and global quality of life scores compared to the control group.
[Effects of Couplet Medicines (Astragalus Membranaceus and Jiaozhen) on Intestinal Barrier in Postoperative Colorectal Cancer Patients].
RCT of 90 postoperative colorectal cancer patients comparing the effects of Astragalus Membranaceus and Jiaozhen (CM) to glutamine (WM) and a control group on intestinal barrier functions. CM showed similar efficacy to WM in improving blood D-lactic acid levels, DAO levels, and urinary L/M ratio, and was superior in reducing ET and TNF-alpha levels and shortening bowel sound recovery time.
Effects of Astragalus membranaceus root processed to different particle sizes on growth performance, antioxidant status, and serum metabolites of broiler chickens.
The study assessed the effects of Astragalus membranaceus root powder (AMP) processed to different particle sizes on broiler chickens. AMP supplementation increased serum antioxidant enzyme activity and decreased malondialdehyde and cholesterol levels, with efficacy improving as particle size decreased. However, it had no effect on growth performance.
A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study.
Phase II double-blind, randomized placebo-controlled study investigating the efficacy of PG2, a partially purified extract of Astragalus membranaceus, for managing cancer-related fatigue in advanced cancer patients. PG2 significantly improved fatigue symptoms compared to placebo, with sustained benefits observed in subsequent treatment cycles.
[Effects of tangshen recipe on the homocysteine metabolism of patients with diabetic nephropathy].
RCT comparing Tangshen Recipe (TR) with Western medicine in 64 patients with diabetic nephropathy. TR, consisting of various herbs, showed similar favorable effects to Western medicine, improving in vivo hypomethylation and oxidative stress without adverse reactions.
The protective effects of the traditional Chinese herbs against renal damage induced by extracorporeal shock wave lithotripsy: a clinical study.
RCT investigating the protective effects of traditional Chinese herbs, including Astragalus membranaceus and Salvia miltiorrhiza, against renal damage induced by extracorporeal shock wave lithotripsy (ESWL) in 60 patients. The medication group showed reduced renal tubular damage and shorter recovery time compared to controls.
[Clinical evaluation of the antioxidant activity of astragalus in women with gestational diabetes].
RCT evaluating the antioxidant activity of astragalus in 84 pregnant women with gestational diabetes. The group receiving both insulin and astragalus showed increased serum SOD activity, decreased MDA levels, improved renal function, and better blood lipid profiles compared to the insulin-only group.
A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) on menopausal symptoms in Hong Kong Chinese women.
A 6-month randomized, double-blind, placebo-controlled study examined the effect of Dang Gui Buxue Tang on menopausal symptoms in Hong Kong Chinese women. The study found no significant difference between Dang Gui Buxue Tang and placebo in treating vasomotor symptoms, though it was statistically superior to placebo for mild hot flushes. No serious adverse events were reported.
[Integrated treatment of traditional Chinese medicine and western medicine for early- and intermediate-stage diabetic nephropathy].
RCT of 120 DN patients comparing basic treatment, TSQ herbal preparation, and TSQ with alprostadil injections. Treatment groups showed better therapeutic effects than control, with significant reductions in fibrinogen, 24-h urine microprotein, and urine protein.
Clinical study on effect of Astragalus Injection and its immuno-regulation action in treating chronic aplastic anemia.
RCT of 60 patients with chronic aplastic anemia comparing Astragalus Injection plus Stanozolol to Stanozolol alone. The treated group showed higher total effective rate and improved hemopoietic function, T-lymphocyte subsets, and reduced serum TNF-alpha and IL-2 levels compared to the control group.
Effect of astragalus injection on serious abdominal traumatic patients' cellular immunity.
RCT of 63 serious abdominal traumatic patients comparing conventional treatment with and without Astragalus Injection (AI). AI improved cellular immunity markers, bringing them closer to healthy subject values by day 14.
Effects of beta-glucan obtained from the Chinese herb Astragalus membranaceus and lipopolysaccharide challenge on performance, immunological, adrenal, and somatotropic responses of weanling pigs.
RCT studying the effects of beta-glucan from Astragalus membranaceus and LPS challenge on weanling pigs. Beta-glucan did not improve performance but decreased inflammatory cytokine and corticosteroid release and improved lymphocyte proliferation via enhanced IL-2 bioactivity.
[Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis].
RCT exploring the effect of Astragalus membranaceus on serum cytokines in 106 patients with herpes simplex keratitis. The AM group showed significant improvement in Th1/Th2 cytokine balance and immune function compared to the ribavirin group.
[Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor].
RCT of 120 tumor patients comparing chemotherapy with and without Astragalus membranaceus injection. The treated group showed lower progressive incidence, lesser decrease in WBC and platelet count, improved CD4/CD8 ratio, and elevated IgG and IgM levels, suggesting enhanced immune function and improved quality of life.
[Effect of Astragalus injection on platelet function and plasma endothelin in patients with early stage diabetic nephropathy].
RCT of 136 early stage diabetic nephropathy patients comparing conventional treatment to Astragalus injection over 3 weeks. Astragalus treatment lowered plasma ET-1, GMP-140, TXB2, and uAER levels, suggesting improvement in platelet function and endothelin levels.
Astragalus Injection alleviates Diabetic Cognitive Impairment (DCI) through dual effects of anti-neuroinflammation and antioxidative stress based on network pharmacology analysis and experimental validation
The study explores the effects of astragalus injection (AI) on diabetic cognitive impairment (DCI) using network pharmacology analysis and experimental validation. AI was found to alleviate DCI through antioxidant and anti-inflammatory mechanisms, activating the Keap1/Nrf2 signaling pathway and inhibiting the TLR-4/NF-κB signaling pathway.
Investigating the molecular mechanisms of the “Astragalus-Codonopsis” herb pair in treating diabetes: a network pharmacology and bioinformatics approach with molecular docking validation
The study investigates the molecular mechanisms of the Astragalus-Codonopsis herb pair in treating diabetes using network pharmacology and bioinformatics. Rhamnolitrin and folic acid were identified as key active components that regulate the insulin receptor signaling pathway, with GSK3β as a critical target. Molecular docking and dynamics simulations confirmed stable binding of these compounds with GSK3β, providing insights into their anti-diabetic effects.
Network pharmacology identifies AKR1C3 and KYNU as potential targets of Astragalus Membranaceus and Ephedra in pediatric obesity-associated asthma
The study used network pharmacology and bioinformatics to identify AKR1C3 and KYNU as potential targets of Astragalus membranaceus and Ephedra in pediatric obesity-associated asthma. The research involved gene expression analysis, machine learning, and molecular docking, identifying these genes as key targets and suggesting therapeutic relevance of compounds derived from these herbs.
Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking
The study investigates the mechanism of Astragalus membranaceus (Huangqi) in treating heart failure using network pharmacology and molecular docking. It identifies five active ingredients that reduce cardiomyocyte enlargement and inflammation, suggesting potential cardioprotective effects through ESR1 regulation.
Explore the mechanism of Astragalus membranaceus and Poria cocos drug pair in improving immunity based on network pharmacology
The study investigates the key targets and molecular mechanisms of the drug pair Astragalus membranaceus and Poria cocos in improving immunity using network pharmacology, molecular docking, and immune infiltration techniques. It identifies active ingredients, target genes, and pathways involved in immunity regulation, suggesting that the drug pair may enhance immune function through multiple components, targets, and pathways.
Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Astragalus–Atractylodes Herb Pair in Treating Hepatocellular Carcinoma
The study investigates the mechanism of action of the Astragalus-Atractylodes herb pair (HQBZ) in treating hepatocellular carcinoma (HCC). Network pharmacology and molecular docking studies suggest that HQBZ targets IL-6 and STAT3 through biatractylolide, affecting the IL-6/STAT3 signaling pathway. In vitro and in vivo experiments indicate HQBZ's potential to regulate this pathway, inhibit CD8+T cell exhaustion, and increase tumor-infiltrating CD8+T cells.
RETRACTED: Prediction of potential targets and toxicological insights of Astragalus in liver cancer based on network pharmacology: Integrating systems biology, drug interaction networks, and toxicological perspectives
The study investigates Astragalus's potential as a therapeutic option for primary liver cancer, focusing on its anti-inflammatory and antiviral effects. Network pharmacology was used to identify potential targets, revealing significant gene expression changes and interactions with MT proteins, suggesting a targeted therapeutic mechanism.
Exploring the target and molecular mechanism of Astragalus membranaceus in the treatment of vascular cognitive impairment based on network pharmacology and molecular docking
The study investigates the molecular mechanism of Astragalus membranaceus (AM) in treating vascular cognitive impairment (VCI) using network pharmacology and molecular docking. It identifies MAPK3 and MMP9 as critical targets and highlights pathways like PI3K/Akt and MAPK. Calycosin and quercetin are potential active compounds of AM for VCI treatment.
Based on network pharmacology and bioinformatics to analyze the mechanism of action of Astragalus membranaceus in the treatment of vitiligo and COVID-19
The study uses network pharmacology and bioinformatics to analyze the mechanism of action of Astragalus membranaceus in treating vitiligo and COVID-19. It identifies active ingredients and potential targets, highlighting pathways like IL-17 signaling and Th17 cell differentiation.
Exploring the role and mechanism of Astragalus membranaceus and radix paeoniae rubra in idiopathic pulmonary fibrosis through network pharmacology and experimental validation
The study explores the role and mechanism of Astragalus membranaceus and Radix paeoniae rubra in idiopathic pulmonary fibrosis (IPF) using network pharmacology and experimental validation. It identifies key targets and pathways involved in IPF and demonstrates that these substances can alleviate lung fibrotic damage in vivo, suggesting their therapeutic potential.
A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Astragalus membranaceus for Glioma
The study explores the potential pharmacological mechanism of Astragalus membranaceus for glioma using network pharmacology and molecular docking. It identifies active compounds and targets involved in pathways related to cancer, neuroactive ligand-receptor interaction, and inflammatory response, suggesting a multicomponent and multitarget therapeutic impact.
The Cardioprotective Effects and Mechanisms of Astragalus-Safflower Herb Pairs on Coronary Heart Disease Identified by Network Pharmacology and Experimental Verification.
The study investigates the cardioprotective effects and mechanisms of Astragalus-Safflower herb pairs on coronary heart disease (CHD) using network pharmacology and experimental verification. It identifies active compounds and target genes, highlighting the NLRP3 inflammasome-mediated signaling pathway as critical. Animal experiments showed decreased expression of NLRP3, Caspase-1, GSDMD, and IL-1β mRNA and protein levels after intervention with ASHP.
Uncovering the effects and molecular mechanism of Astragalus membranaceus (Fisch.) Bunge and its bioactive ingredients formononetin and calycosin against colon cancer: An integrated approach based on network pharmacology analysis coupled with experimental validation and molecular docking
The study investigates the effects and mechanisms of Astragalus membranaceus and its bioactive ingredients, formononetin and calycosin, against colon cancer. Using network pharmacology, experimental validation, and molecular docking, the study found that these substances significantly suppressed cancer cell viability and proliferation, promoted apoptosis, and inhibited cell migration by affecting the ERK1/2 signaling pathway.
Investigation of the mechanism of Astragalus membranaceus in the treatment of lumbar disc herniation using network pharmacology
The study investigates the mechanisms of Astragalus membranaceus in treating lumbar disc herniation using network pharmacology and an in vitro model. The active components of Astragalus membranaceus inhibited inflammation by suppressing IL-1β and IL-6 production and increasing VEGF A, MMP9, and MMP2 expressions in an LPS-induced LDH model.
Exploring the mechanism of astragalus membranaceus in the treatment of multiple system atrophy based on network pharmacology and molecular docking
The study explores the mechanism of Astragalus membranaceus in treating multiple system atrophy using network pharmacology and molecular docking. It identifies core components like quercetin, kaempferol, and isorhamnetin, and core targets such as TP53, RELA, and TNF, suggesting AM treats MSA through multiple targets and pathways.
Network Pharmacology and Molecular Docking-Based Investigation of Potential Targets of Astragalus membranaceus and Angelica sinensis Compound Acting on Spinal Cord Injury
The study investigates the potential targets and mechanisms of Astragalus membranaceus and Angelica sinensis in treating spinal cord injury using network pharmacology and molecular docking. It identifies 22 active compounds and 159 SCI-related targets, with key active ingredients including quercetin, kaempferol, isorhamnetin, and formononetin.
The mechanism of action of the combination of Astragalus membranaceus and Ligusticum chuanxiong in the treatment of ischemic stroke based on network pharmacology and molecular docking
The study investigates the pharmacological mechanism of Astragalus membranaceus and Ligusticum chuanxiong in treating ischemic stroke using network pharmacology and molecular docking. It identifies 26 active ingredients and 161 common targets with ischemic stroke, highlighting the role of inflammatory pathways in the treatment mechanism.
Network Pharmacology and Molecular Docking Analysis on Pharmacological Mechanisms of Astragalus membranaceus in the Treatment of Gastric Ulcer
The study explores the pharmacological mechanisms of Astragalus membranaceus in treating gastric ulcer using network pharmacology and molecular docking. Key ingredients like quercetin, kaempferol, and isorhamnetin were identified, and multiple biological processes and signaling pathways related to inflammation, oxidative stress, apoptosis, cell proliferation, and angiogenesis were involved.
Study on the mechanism of Astragalus-Panax notoginseng in the treatment of gastric ulcer based on network pharmacology
The study explores the mechanism of Astragalus-Panax notoginseng in treating gastric ulcer using network pharmacology. It identifies 27 potential active components, 488 drug targets, and 118 drug-disease common targets, with KEGG enrichment analysis highlighting several related signal pathways.
Network Pharmacology-Based Analysis on the Mechanism of Drug Pair of Astragalus Membranaceus and Acorus Tatarinowii in the Treatment of Alzheimer’s Disease
The study uses network pharmacology to analyze the potential targets and molecular mechanisms of the drug pair Astragalus membranaceus and Acorus tatarinowii in treating Alzheimer's disease. It identifies active ingredients and drug targets, constructs networks, and performs enrichment analyses to predict the systematic regulating action of the drug pair.
Mechanism Prediction of Astragalus membranaceus against Cisplatin-Induced Kidney Damage by Network Pharmacology and Molecular Docking
The study uses network pharmacology and molecular docking to predict the mechanism of Astragalus membranaceus (AM) in mitigating cisplatin-induced kidney damage. It identifies 20 active components and 200 targets of AM, with 91 intersection targets related to kidney damage. Key pathways include MAPK, Toll-like receptor, and PI3K-Akt signaling.
Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis
The study investigates the effects and mechanism of Astragalus flavonoids against hepatic fibrosis using network pharmacology, experimental validation, and molecular docking. Flavonoids from Astragalus were shown to suppress TGF-β1-mediated activation of hepatic stellate cells and reduce extracellular matrix deposition via the NF-κB pathway, suggesting an anti-inflammatory effect.
Network Pharmacology-Based Investigation of Potential Targets of Astragalus-Angelica Compound Acting on Diabetic Nephropathy
The study uses network pharmacology and molecular docking to explore the mechanism of astragalus-angelica compound in treating diabetic nephropathy. It identifies 142 main targets related to apoptosis, oxidative stress, inflammation, and insulin resistance, suggesting potential pathways for treatment.
Exploring the mechanism of Astragalus membranaceus against uterine fibroids based on network pharmacology
The study investigates the mechanism of action of Astragalus membranaceus against uterine fibroids using a network pharmacology approach. It identifies 21 active ingredients and 406 drug targets, with 17 overlapping with uterine fibroid disease targets. The study highlights the multicomponent and multi-target properties of astragalus in the treatment of uterine fibroids.
A Network Pharmacology to Explore the Mechanism of Astragalus Membranaceus in the Treatment of Diabetic Retinopathy
The study explores the potential mechanism of Astragalus Membranaceus in the treatment of diabetic retinopathy using network pharmacology. It identifies 24 active compounds and 38 core targets involved in oxidative stress, angiogenesis, and inflammation, suggesting a multi-target approach in treating diabetic retinopathy.
Uncovering the Mechanism of Astragalus membranaceus in the Treatment of Diabetic Nephropathy Based on Network Pharmacology
The study uses network pharmacology to explore the mechanism of Astragalus membranaceus (AM) in treating diabetic nephropathy (DN). It identifies 16 active ingredients and 78 potential target genes, with 42 overlapping with DN targets. The analysis highlights AM's multicomponent, multitarget, and multichannel characteristics, suggesting its therapeutic potential in DN through pathways related to inflammation, angiogenesis, and oxidative stress.
Astragalus membranaceus up-regulate Cosmc expression and reverse IgA dys-glycosylation in IgA nephropathy.
The study investigated the effect of Astragalus membranaceus on Cosmc expression and IgA O-glycosylation in peripheral B lymphocytes of IgA nephropathy patients. Astragalus membranaceus up-regulated Cosmc expression, decreased IgA1 secretion, and reversed glycosylation levels in a dose-related manner.
'Huang Qi Elixir' for proteinuria in patients with diabetic nephropathy: a study protocol for a randomized controlled pilot trial.
This is a study protocol for a randomized controlled pilot trial to evaluate the efficacy of 'Huang Qi Elixir' in treating proteinuria in patients with diabetic nephropathy. Forty-eight participants will be randomly assigned to different treatment groups, including two granule groups, a decoction group, and an irbesartan group, to assess changes in albumin-to-creatinine ratio and other renal function markers.
Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis.
A 6-week, double-blind, placebo-controlled clinical trial investigated the efficacy and safety of Astragalus membranaceus in 48 adult patients with moderate to severe seasonal allergic rhinitis. The herbal and mineral complex significantly decreased rhinorrhea intensity compared to placebo, and improvements in symptom score and quality of life were noted, particularly in patients with weed pollen allergy.
[Effects of astragalus injection on renal function in patients after cardiac valve replacement with cardiopulmonary bypass].
RCT of 40 patients undergoing cardiac valve replacement with CPB, comparing Astragalus Injection to control. Astragalus Injection group showed lower serum BUN, Cr, and urinary markers, suggesting renal protection.
Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study.
A randomised, double-blind, controlled clinical trial with 36 adults with chronic fatigue tested the anti-fatigue effects of Myelophil, an extract of Astragali Radix and Salviae Radix. Myelophil administration (3g per day) significantly decreased fatigue severity scores compared to control, with no changes in cytokine expression.