Research
Artichoke Extract
46 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence.
This systematic review and meta-analysis evaluated the effects of artichoke supplementation on cardiometabolic health markers in adults. Artichoke supplementation significantly reduced body mass index, waist circumference, blood pressure, and improved lipid profiles and insulin resistance, with no significant effects on body weight, hip circumference, fasting blood glucose, or HbA1c.
Effects of different natural products in patients with non-alcoholic fatty liver disease-A network meta-analysis of randomized controlled trials.
Network meta-analysis of 37 RCTs with 2509 patients evaluating the effects of seven natural products on NAFLD. Artichoke leaf extract showed advantages in reducing AST, ALT, and LDL-C levels, while naringenin reduced TG and TC levels and improved HDL-C levels. Catechins significantly reduced BMI levels.
Therapeutic Potential of Artichoke in the Treatment of Fatty Liver: A Systematic Review and Meta-Analysis.
This meta-analysis summarizes evidence from five RCTs involving 333 NAFLD patients, showing that artichoke leaf extract (ALE) significantly reduced alanine aminotransferase, aspartate aminotransferase, total cholesterol, low-density lipoprotein, and triglycerides compared to control. The review supports ALE's use as a hepatoprotective agent in NAFLD patients.
Effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters: a systematic review.
Systematic review examining the modification effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters. Two RCTs found that artichoke extract supplementation significantly decreased insulin concentration and improved insulin resistance in the TT genotype of the rs7903146 variant of TCF7L2.
Effects of artichoke on blood pressure: A systematic review and meta-analysis.
Systematic review and meta-analysis of eight RCTs assessing artichoke supplementation on blood pressure. Overall, artichoke did not affect SBP or DBP, but subgroup analysis showed significant reductions in hypertensive patients and with 12-week supplementation.
The effects of Cynara scolymus L. supplementation on liver enzymes: A systematic review and meta-analysis.
A systematic review and meta-analysis of eight clinical trials found that artichoke supplementation significantly reduced liver enzymes AST and ALT, particularly in patients with non-alcoholic fatty liver disease and overweight/obese subjects.
Effects of Cynara scolymus L. on glycemic indices:A systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of nine RCTs evaluating the effects of artichoke and artichoke products on glycemic indices. The administration of artichoke significantly reduced fasting blood sugar levels, but did not significantly alter fasting insulin, HOMA-IR, or HbA1c. Subgroup analysis showed artichoke supplementation was effective in reducing HOMA-IR.
The effects of supplementation with Cynara scolymus L. on anthropometric indices: А systematic review and dose-response meta-analysis of clinical trials.
Systematic review and dose-response meta-analysis of 10 RCTs on artichoke supplementation effects on anthropometric indices. Artichoke administration showed a reduction in waist circumference but not in weight or BMI overall. In hypertensive patients, artichoke significantly reduced weight.
Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis.
This meta-analysis of 9 trials with 702 subjects evaluated the effect of artichoke extract supplementation on plasma lipid levels. The results showed a significant decrease in total cholesterol, LDL-C, and triglycerides, with no significant change in HDL-C. Artichoke extract supplementation may aid in lipid-lowering therapy for hyperlipidemia.
Artichoke leaf extract for treating hypercholesterolaemia.
Meta-analysis of three RCTs involving 262 participants assessing artichoke leaf extract (ALE) for treating hypercholesterolaemia. ALE showed potential in lowering cholesterol levels, with statistically significant reductions in total cholesterol compared to placebo in some trials. Mild, transient, and infrequent adverse events were reported.
Artichoke leaf extract for treating hypercholesterolaemia.
Meta-analysis of three RCTs with 262 participants assessing artichoke leaf extract (ALE) for treating hypercholesterolaemia. ALE showed a statistically significant reduction in total cholesterol levels compared to placebo in some trials, though the evidence is not yet convincing. Mild, transient, and infrequent adverse events were reported.
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels.
RCT assessing the effect of a dietary supplement containing bergamot and artichoke extracts on metabolic and vascular risk factors in 90 individuals with suboptimal cholesterol levels. The active-treated group showed significant improvements in lipid profiles, insulin sensitivity, hs-CRP, and NAFLD indexes compared to baseline and placebo.
A new nutraceutical (Livogen Plus®) improves liver steatosis in adults with non-alcoholic fatty liver disease.
RCT of 140 participants with liver steatosis comparing Livogen Plus, a combination of bioactive molecules, to placebo over 12 weeks. The nutraceutical group showed a greater reduction in liver fat content (CAP score) compared to placebo, indicating effectiveness in reducing liver steatosis.
Effect of Dietary Supplementation with EufortynColesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of Non-Alcoholic Fatty Liver Disease and Systemic Inflammation in Healthy Subjects with Polygenic Hypercholesterolemia: The ANEMONE Study.
RCT evaluating the effects of EufortynColesterolo Plus, containing bergamot polyphenolic fraction, artichoke extracts, Q10 phytosome, and zinc, on serum lipids, systemic inflammation, and NAFLD indexes in 60 subjects with polygenic hypercholesterolemia. The supplement significantly improved cholesterol levels, inflammation markers, and endothelial reactivity compared to placebo.
Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia
RCT of 60 overweight adults with mild hypercholesterolemia comparing supplementation with bergamot phytosome and artichoke leaf extract to placebo over 2 months. The supplemented group showed significant decreases in total and LDL cholesterol, waist circumference, and visceral adipose tissue compared to placebo.
The effects of co‐administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial
Randomized clinical trial investigating the effect of co-administration of artichoke leaf extract with metformin and vitamin E in patients with nonalcoholic fatty liver disease. The study found significant reductions in ALT and AST levels and decreased liver fat accumulation in all groups after 12 weeks.
The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
Double-blind, placebo-controlled RCT of 54 overweight subjects with impaired fasting glucose, testing Cynara scolymus extract. Significant improvements were observed in glycemic control, insulin sensitivity, and various metabolic parameters including cholesterol levels and waist circumference.
The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta-analysis of animal studies.
Systematic review and meta-analysis of animal studies on the antioxidant effects of artichoke. Artichoke extract supplementation increased antioxidant enzyme levels and decreased malondialdehyde levels in animals with induced disease, supporting its antioxidant activity.
WITHDRAWN: Artichoke leaf extract for treating hypercholesterolaemia.
The title regarding artichoke leaf extract for treating hypercholesterolaemia has been withdrawn by the editors of Cochrane Heart due to low priority for the current portfolio. The document is no longer open to a new author team.
Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial.
Double-blind RCT with 244 patients assessing artichoke leaf extract (ALE) for functional dyspepsia. ALE significantly improved dyspeptic symptoms and quality of life compared to placebo over 6 weeks.
Artichoke leaf extract for treating hypercholesterolaemia.
Systematic review assessing the efficacy of artichoke leaf extract (ALE) for treating hypercholesterolaemia. Two randomized trials with 167 participants showed ALE reduced total cholesterol levels compared to placebo, but evidence is not compelling. Mild, transient, and infrequent adverse events were reported.
The effects of a novel nutraceutical combination on low-density lipoprotein cholesterol and other markers of cardiometabolic health in adults with hypercholesterolaemia: A randomised double-blind placebo-controlled trial.
RCT of 42 adults with mild hypercholesterolaemia testing a nutraceutical combination of plant sterols, bergamot extract, artichoke leaf extract, and hydroxytyrosol. The study found no significant effect on serum LDL-cholesterol or other cardiometabolic and oxidative stress markers compared to placebo.
Artichoke leaf extract reduces steatosis and decreases liver size in prebariatric patients: A randomized placebo-controlled pilot trial-The "SteatoChoke-Study".
RCT of 40 prebariatric patients comparing artichoke leaf extract (ALE) to placebo for 6 weeks. ALE significantly reduced liver steatosis and size, improved body composition, and improved cholesterol levels in female participants. However, transaminase levels increased in the ALE group.
Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial.
Phase II clinical trial testing artichoke freeze-dried extract (AWPC) in 18 male patients with asbestos exposure-related conditions. AWPC modulated 11 serum miRNAs related to mesothelioma etiology and development, with no significant effect on mesothelin serum levels. No severe adverse effects were observed, only gastrointestinal symptoms in some participants.
Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial.
This randomized double-blind placebo-controlled trial assessed the efficacy of artichoke leaf extract (ALE) in 100 patients with non-alcoholic fatty liver disease (NAFLD). ALE supplementation showed beneficial effects on ultrasound liver parameters and liver serum parameters, including ALT, AST, APRI ratio, and total bilirubin, compared to placebo.
TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial.
This randomized, double-blind, placebo-controlled trial studied the effects of artichoke leaf extract (ALE) supplementation on metabolic parameters in 80 patients with metabolic syndrome. ALE supplementation decreased insulin levels and HOMA-IR in patients with the TT genotype of TCF7L2-rs7903146 polymorphism, with no significant effects on blood pressure, glucose, and lipid profile.
Short-Term Effects of Dry Extracts of Artichokeand Berberis in Hypercholesterolemic Patients Without Cardiovascular Disease.
Pilot clinical trial testing a nutraceutical containing artichoke dry extract and berberine in hypercholesterolemic patients. After 2 months, the nutraceutical significantly reduced plasma total cholesterol, LDL cholesterol, non-HDL cholesterol, and triglyceride levels without side effects.
Antioxidant response to artichoke leaf extract supplementation in metabolic syndrome: A double-blind placebo-controlled randomized clinical trial.
Double-blind placebo-controlled RCT of 80 patients with Metabolic Syndrome examining the effects of artichoke leaf extract (ALE) on oxidative stress indices. ALE significantly decreased serum ox-LDL levels compared to placebo, but showed no significant effects on other antioxidant indices.
Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms.
Double-blind randomized clinical trial of 50 women with metabolic syndrome, investigating the effects of artichoke leaf extract supplementation on metabolic parameters. ALE supplementation resulted in a significant decrease in serum triglyceride levels in carriers of the A allele of the FTO-rs9939609 polymorphism, with no other significant differences observed.
Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynara scolymus: a double-blind, placebo-controlled, randomized clinical trial.
A double-blind, placebo-controlled RCT evaluated the efficacy of Cynara scolymus extract on glucose patterns in 55 overweight subjects with impaired fasting glycaemia. The supplemented group showed significant decreases in fasting blood glucose, HOMA, glycosylated haemoglobin, ADAG, and lipidic pattern compared to placebo.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
A double-blind, randomized, placebo-controlled trial evaluated the effects of artichoke leaf extract supplementation on lipid patterns in 92 overweight subjects with primary mild hypercholesterolaemia over 8 weeks. The supplementation group showed a significant increase in HDL-cholesterol and a decrease in total cholesterol, LDL-cholesterol, and cholesterol ratios compared to placebo.
[Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms].
Cohort study of 311 outpatients with functional dyspepsia treated with Cinarepa, a mixture containing artichoke leaf extract, dandelion, turmeric, and rosemary. Significant reduction in dyspepsia symptom severity was observed at 30 and 60 days, with improvements in lipid profile and liver function in patients with elevated baseline values.
Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial.
RCT of 75 hypercholesterolemic adults assessing the effect of 1280 mg daily artichoke leaf extract (ALE) on plasma lipid levels over 12 weeks. ALE consumption resulted in a modest but statistically significant reduction in total cholesterol compared to placebo, with no significant differences in LDL, HDL, or triglyceride levels.
Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial.
The study used an innovative ex vivo clinical trial to assess the metabolic and anti-inflammatory properties of artichoke leaf extract. Human serum enriched with metabolites from the extract was incubated with human hepatocytes, chondrocytes, and adipocytes, showing protective effects against lipotoxic stress, prevention of adipocyte differentiation, and chondroprotective properties.
The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.
RCT of 40 hypertensive patients evaluating the effect of artichoke (Cynara scolymus) supplementation on blood pressure and BMI. The treatment group received 500 mg of artichoke twice daily for 8 weeks, showing significant improvement in BMI compared to placebo.
The effect of artichoke leaf extract supplementation on lipid profile of chronic kidney disease patients; a double-blind, randomized clinical trial
A double-blind, randomized clinical trial in 38 CKD patients with hypercholesterolemia evaluated the effects of artichoke leaf extract supplementation on lipid profile. ALE supplementation significantly decreased total cholesterol and LDL-C levels compared to placebo, and improved appetite.
Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial
Double-blind, cross-over RCT of a nutraceutical combination including artichoke, red yeast rice, banaba, and coenzyme Q10 in 30 adults with suboptimal LDL cholesterol. The treatment significantly improved total cholesterol, LDL-C, non-HDL-C, liver transaminases, and hs-CRP compared to placebo.
Appetite control and glycaemia reduction in overweight subjects treated with a combination of two highly standardized extracts from Phaseolus vulgaris and Cynara scolymus.
RCT of 39 overweight subjects evaluating the efficacy of a dietary supplement with extracts from Phaseolus vulgaris and Cynara scolymus on satiation, glucose, and lipid patterns. The intervention group showed significant improvements in satiation, glycaemia reduction, and other metabolic parameters compared to placebo.
The influence of supplementation with artichoke (Cynara scolymus L.) extract on selected redox parameters in rowers.
Double-blinded RCT with 22 competitive rowers assessing the effects of artichoke-leaf extract supplementation on redox parameters. The supplemented group showed higher plasma total antioxidant capacity and lower serum total cholesterol levels compared to placebo, but no reduction in oxidative damage to erythrocytes.
Artichoke juice improves endothelial function in hyperlipemia.
RCT investigating the effects of dietary supplementation with artichoke juice on endothelial function in hyperlipemic patients. Artichoke juice improved brachial flow-mediated vasodilation and reduced VCAM-1 and ICAM-1 levels, indicating a positive modulation of endothelial function.
Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial.
RCT testing the effectiveness of artichoke extract in preventing alcohol-induced hangover symptoms in 15 healthy adult volunteers. Participants received artichoke extract or placebo before and after alcohol exposure. No significant differences in hangover severity, mood, or cognitive performance were found between the interventions.
Artichoke leaf extract reduces mild dyspepsia in an open study.
Open, dose-ranging postal study on artichoke leaf extract (ALE) in 454 participants with self-reported dyspepsia. ALE significantly reduced dyspeptic symptoms by 40% and improved quality of life. Higher dosage showed greater relief of state anxiety.
Caffeic acid derivatives in artichoke extract are metabolised to phenolic acids in vivo.
The study investigated the absorption and metabolism of hydroxycinnamates from artichoke extract by measuring urinary excretion of metabolites in 10 healthy volunteers. Caffeic acid esters in the artichoke extract were absorbed and metabolized to phenolic acids such as ferulic, isoferulic, dihydroferulic, and vanillic acid, which were detected in urine after beta-glucuronidase treatment.
Artichoke Leaf Extract-Mediated Neuroprotection against Effects of Aflatoxin in Male Rats
Animal study on the neuroprotective effects of artichoke leaf extract against aflatoxin B1-induced neurotoxicity in male rats. Artichoke leaf extract significantly reduced adverse effects caused by aflatoxin B1, restoring parameters to levels similar to unexposed controls.
Functional and Therapeutic Potential ofin Health Benefits.
The review discusses the nutritional profiles, potential benefits, and pharmacological effects of artichoke, highlighting its anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial, and lipid-lowering properties. Artichoke's polyphenols exhibit antioxidant activity, reducing the risk of conditions such as cancer, diabetes, and cardiovascular diseases.
Effects of Prickly Pear Dried Leaves, Artichoke Leaves, Turmeric and Garlic Extracts, and Their Combinations on Preventing Dyslipidemia in Rats
The study evaluated the anti-dyslipidemic properties of artichoke, turmeric, prickly pear, and garlic extracts, alone and in combination, in hyperlipidemic rat models. Short and long-term treatments with these combinations significantly improved lipid profiles by lowering LDL and LDL/HDL ratios, and increasing HDL levels. Artichoke and prickly pear also inhibited HMG-CoA reductase activity.