Research
Alpha-GPC
6 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects Of Alpha-gpc And Huperzine-a On Memory And Power Output Post Exhaustion
Double-blind, placebo-controlled RCT on 62 healthy adults examining the effects of Alpha-GPC and Huperzine-A on short-term memory and anaerobic power output post-exhaustion. The study found no significant difference in performance pre to post, between groups, or in percent change, suggesting no physical or mental benefit from acute dosing of these supplements.
alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial.
A clinical open multicenter trial tested the efficacy and tolerability of alpha-glycerophosphocholine (alpha-GPC) in 2044 patients with recent stroke or transient ischemic attacks. Alpha-GPC improved cognitive recovery as measured by several scales, with significant improvements in scores. Adverse events were reported by 2.14% of patients, confirming its therapeutic role and excellent tolerability.
The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility
The study measured the acute effects of Alpha-GPC supplementation compared to caffeine or placebo on mood, cognitive function, and physiological performance. Alpha-GPC is noted for increasing acetylcholine release, facilitating learning and memory, and enhancing endurance performance and growth hormone secretion.
A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia.
Open clinical trial comparing 1 g/day alpha-glycerylphosphorylcholine (alpha-GPC) with 1 g/day cytosine diphosphocholine (CDP) in 120 patients with mild to moderate vascular dementia over 90 days. Both treatments improved symptoms and were well tolerated, with alpha-GPC showing statistically higher efficacy in most tests.
A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers.
This study evaluated the profile of free plasma choline levels following a single intramuscular dose of alpha-GPC in 12 normal volunteers, with citicoline included for comparison. Alpha-GPC administration resulted in a rapid rise in plasma choline levels, peaking at 0.25 to 0.5 hours post-injection, while citicoline showed a similar but lower time course.
Cognition stimulating drugs modulate protein kinase C activity in cerebral cortex and hippocampus of adult rats.
The study investigated the effects of oxiracetam, aniracetam, and alpha-glycerylphosphorylcholine (alpha GPC) on protein kinase C (PKC) activity in rat brain cortex and hippocampus. Oxiracetam and alpha GPC increased particulate PKC activity in vivo and in vitro, while aniracetam promoted PKC translocation in the hippocampus. The study suggests PKC activation as a common mechanism among cognition-stimulating drugs.