Research
Aloe Vera
48 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effectiveness of Aloe vera in the treatment of oral mucositis: a systematic review and meta-analysis of randomized controlled trials.
A systematic review and meta-analysis of seven RCTs involving 355 cancer patients assessed the effectiveness of Aloe vera in treating oral mucositis. Aloe vera showed significant improvement in severe mucositis cases (grades 3 and 4) compared to placebo, but not compared to sodium bicarbonate or benzydamine.
The effect of different mouthwashes to prevent oral mucositis in patients with radiotherapy and chemotherapy: a network meta-analysis.
Network meta-analysis of 36 RCTs comparing the effectiveness of 13 mouthwashes in preventing oral mucositis in patients undergoing radiotherapy and chemotherapy. Aloe vera juice was ranked as the most effective, followed by Chinese herbal medicine and other substances.
CLINICAL EFFECT OF LOCAL ALOE VERA USE AS AN ADJUNCT TO PERIODONTAL THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS.
This systematic review and meta-analysis investigated the clinical efficacy of Aloe Vera as an adjunct to scaling and root planning (SRP) for nonsurgical periodontal therapy. Aloe Vera treatment reduced probing pocket depth and clinical attachment level compared to control, indicating improved periodontal treatment outcomes. However, no significant differences were observed in reducing plaque index and bleeding index at 6 months.
Effectiveness of the Application of Lanolin, Aloe Vera, and Peppermint on Nipple Pain and Nipple Trauma in Lactating Mothers: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 11 studies with 1,495 participants examining the effectiveness of lanolin, aloe vera, and peppermint on nipple pain and trauma in lactating mothers. Lanolin significantly reduced nipple pain and trauma, while peppermint significantly reduced nipple trauma.
Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of RCTs examining Aloe vera's effects on burn injuries. Aloe vera significantly reduced wound-healing time compared to other topicals, but showed no significant differences in pain reduction or wound infection risk.
Comparative effectiveness of medicinal interventions for oral submucous fibrosis: A network meta-analysis.
Network meta-analysis comparing medical interventions for oral submucous fibrosis (OSMF) in 2393 patients. Combined treatment with steroid, hyaluronidase, and antioxidant was most effective for mouth opening and reducing burning sensation. Aloe vera and pentoxifylline were also effective for burning sensation, while curcumin was most effective for tongue protrusion.
Comparison of ointment-based agents after excisional procedures for hemorrhoidal disease: a network meta-analysis of randomized controlled trials.
Network meta-analysis of 26 RCTs with 2132 patients assessing analgesic efficacy and safety of topical medications after hemorrhoidal surgery. Aloe vera cream scored highest for analgesic profile during defecation at 24 and 48 hours postoperatively.
Effects of Aloe Vera in the Treatment of Oral Ulcers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Systematic review and meta-analysis of 9 RCTs involving 847 participants to assess aloe vera's effects on oral ulcers. Aloe vera showed better clinical efficacy and shorter healing time compared to controls, though no significant differences in pain relief or ulcer size reduction were found.
Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review.
Meta-analysis and systematic review assessing the efficacy of topical aloe vera in wound care, specifically for second-degree burns. Analysis of 4 studies with 133 patients showed a statistically significant mean difference in time to healing of 4.44 days in favor of aloe vera treatment.
Oral lichen planus: comparative efficacy and treatment costs-a systematic review.
Systematic review comparing the efficacy and costs of interventions for oral lichen planus (OLP). The review included 70 RCTs and found that topical steroids, calcineurin inhibitors, retinoids, aloe-vera gel, photodynamic therapy, and low-level laser therapies are effective for OLP management. Topical steroids were found to be the most cost-effective treatment.
Interventions for oral lichen planus: A systematic review and network meta-analysis of randomized clinical trials.
Network meta-analysis of 55 trials with 2831 patients comparing interventions for oral lichen planus. Aloe vera, among other treatments, was significantly associated with superior rates of pain resolution compared to placebo.
The use of babosa (Aloe vera) in treating burns: a literature review.
This systematic review evaluates the effectiveness and safety of Aloe vera in treating burns. It includes studies showing Aloe vera's positive effects on wound healing, such as increased healing speed and antioxidant properties. However, further clinical trials with larger samples are suggested for more conclusive results.
Effectiveness of aloe vera in patients with type 2 Diabetes Mellitus and pre-diabetes: An overview of systematic reviews.
Systematic review analyzing the effects of aloe vera on metabolic profiles in patients with type 2 diabetes mellitus and pre-diabetes. The review found moderate to high quality evidence supporting aloe vera's positive effects on fasting blood glucose, HbA1c, and triglycerides.
Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.
Systematic review and meta-analysis of 23 trials with 4,023 participants on the effects of Aloe vera on mucocutaneous problems. Results showed no significant differences in pain scores but indicated Aloe vera gel application significantly lowered Psoriasis Area Severity Index scores and accelerated wound-healing and tissue epithelialization.
Aloe gel-base food products: Chemical, toxicological, and regulatory aspects.
This review discusses the chemical, toxicological, and regulatory aspects of Aloe gel and other Aloe preparations. It highlights the minimal presence of hydroxyanthracene derivatives (HADs) in Aloe gel compared to other Aloe products and the need for further toxicological studies to establish safe limits for HAD contaminants.
Aloe vera and health outcomes: An umbrella review of systematic reviews and meta-analyses.
This umbrella review summarizes the effects of Aloe vera on health outcomes by analyzing systematic reviews and meta-analyses of clinical trials. It included 10 articles reporting 71 unique outcomes, with 47 outcomes being statistically significant. Highly suggestive evidence supported Aloe vera's benefits in preventing second-degree infusion phlebitis and chemotherapy-induced phlebitis, though most evidence was limited by small sample sizes and poor methodological quality.
Therapeutic Outcomes of Aloe vera Gel Compared with Triamcinolone Acetonide in Minor Aphthous Stomatitis.
RCT comparing Aloe vera gel to triamcinolone acetonide paste in 60 patients with recurrent aphthous stomatitis. Both treatments showed significant improvement by Day 7, with Aloe vera achieving comparable efficacy to triamcinolone, though the steroid offered quicker relief in males.
Efficacy of an Iranian herbal medicine formula for postoperative constipation in trauma patients with hip and lower limb fractures: A triple-blind, placebo-controlled randomized clinical trial.
A triple-blind, placebo-controlled RCT evaluated the efficacy of the Herbal Laxative Capsule (HLC) in managing postoperative constipation in 61 orthopedic patients. The treatment group showed significant improvements in constipation severity and stool consistency compared to placebo, with higher patient satisfaction and no significant adverse effects.
Clinical Assessment of the Efficacy of Natural Nutraceuticals in Gingival Massage Therapy: A Randomized Clinical Study.
RCT assessing the efficacy of gingival massage therapy with Aloe vera gel and sidr honey in reducing gingival inflammation. Both interventions improved clinical parameters like plaque index, gingival index, and bleeding on probing, with sidr honey showing greater effectiveness compared to Aloe vera and control.
The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial.
Double-blind, randomized controlled trial assessing the impact of aloe vera gel on the healing of diabetic foot ulcers in 66 patients. The intervention group showed a more substantial decrease in BWAT scores, suggesting aloe vera may be an effective adjunctive treatment.
Comparison of aloe vera gel dressing with conventional dressing on pressure ulcer pain reduction: a clinical trial.
Double-blind, randomized clinical trial comparing Aloe Vera gel dressing to conventional dressing on pressure ulcer pain reduction in 64 patients. Aloe Vera gel was found to be more effective in reducing pain during dressing changes.
A Randomized Single-Blinded Phase II Trial Comparing Efficacy and Quality of Life of Topical Aloe Vera Gel Plus Urea Cream Versus Urea Cream Alone for Prevention of Hand Foot Syndrome in Cancer Patients Receiving Capecitabine.
Randomized single-blinded phase II trial comparing aloe vera gel plus urea cream versus urea cream alone for preventing hand foot syndrome in cancer patients receiving capecitabine. The combination group had significantly lower incidence of grade 2-3 hand foot syndrome compared to the urea cream alone group.
Efficacy of aloe vera and probiotic mouthwashes vs fluoride mouthwash on Streptococcus mutans in plaque around brackets of orthodontic patients: a randomized clinical trial.
RCT comparing the efficacy of aloe vera and probiotic mouthwashes versus fluoride mouthwash on Streptococcus mutans levels in plaque of orthodontic patients. No significant differences in efficacy among the three mouthwashes were found. Patient compliance was high, and no significant differences in patient-reported outcomes were observed.
Efficacy of Topical Treatments for the Management of Symptomatic Oral Lichen Planus: A Systematic Review.
Systematic review assessing the effectiveness of topical treatments for symptomatic oral lichen planus. Topical corticosteroids are the first-line treatment, while calcineurin inhibitors are effective in recalcitrant cases. Aloe vera, chamomile, isotretinoin, ozone, and laser therapy may be beneficial as adjunct therapies.
Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial.
RCT assessing the efficacy of topical aloe vera gel on radiation-induced dermatitis in head and neck cancer patients. Aloe vera gel significantly reduced moderate to severe grades of skin erythematous and instances of moist desquamation compared to placebo.
Clinical Evaluation of the Effects of Topical Indocyanine-green Mediated Photosensitiser vs Aloe Vera Gel as Adjunct Therapy to Scaling and Root Planing in Chronic Periodontitis Patients.
RCT comparing the efficacy of indocyanine green mediated photodynamic therapy and aloe vera gel as adjuncts to scaling and root planing in chronic periodontitis patients. Aloe vera gel showed significant improvement in clinical parameters and reduction in inflammation markers compared to other groups.
Effect of processed aloe vera gel on immunogenicity in inactivated quadrivalent influenza vaccine and upper respiratory tract infection in healthy adults: A randomized double-blind placebo-controlled trial.
RCT of 100 healthy adults assessing processed aloe vera gel (PAG) as an adjuvant in influenza vaccine and its effect on upper respiratory tract infections (URI). PAG did not significantly increase seroprotection rate but reduced the number of URI episodes.
A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial.
RCT comparing the efficacy of Curcumin gel and Aloe Vera gel, supplemented with oral physiotherapy, in managing oral submucous fibrosis (OSMF). Aloe Vera gel showed better improvement in burning sensation after 6 weeks compared to Curcumin gel, with statistically significant results.
Comparative efficacy of topical aloe vera and low-level laser therapy in the management of oral lichen planus: a randomized clinical trial.
This randomized clinical trial compared the efficacy of topical aloe vera with low-level laser therapy in 60 patients with oral lichen planus. Aloe vera was applied thrice daily, and laser therapy was administered twice weekly for 2 months. Both treatments showed significant improvements, but laser therapy was more effective during the active treatment period. Both treatments were equally effective during the follow-up period.
Randomized clinical trial: Effects of Aloe barbadensis Mill. extract on symptoms, fecal microbiota and fecal metabolite profiles in patients with irritable bowel syndrome.
RCT of Aloe barbadensis Mill. extract in 160 IBS patients comparing its effects to inulin over 4 weeks. Both groups showed reduced IBS symptom severity, but no significant difference between Aloe and control. Fecal microbiota and metabolite profiles differed between Aloe responders and non-responders.
Aloe Vera; A new treatment for atrophic vaginitis, A randomized double-blinded controlled trial.
This double-blinded randomized controlled trial compared the effect of Aloe Vera vaginal cream with estrogen vaginal cream in 60 menopausal women with vaginal atrophy. Both treatments significantly improved vaginal health index, maturity value, and symptoms of vaginal atrophy, with Aloe Vera showing superiority in fluid volume.
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the efficacy of Western herbal medicines in treating IBS. Peppermint essential oil, Aloe vera, and asafoetida showed efficacy in reducing IBS symptoms. Other herbal formulas also demonstrated efficacy but lacked replication.
Development, Characterization, and Clinical Evaluation of a 6% Nitroglycerin-Aloe Vera Transdermal Gel for Stable Angina Management.
A randomized, double-blind clinical trial evaluated a 6% nitroglycerin-Aloe vera gel for stable angina management in 150 patients. The gel showed desirable physicochemical properties, sustained drug release, and improved clinical efficacy and tolerability compared to sublingual nitroglycerin, with no dermatological adverse effects.
Efficacy and Safety of a Dual-Wavelength 589/1319 nm Laser for the Treatment of Acne Erythema: A Split-Face Randomized Controlled Trial.
RCT comparing the efficacy and safety of a 589/1319 nm SSDW laser with Aloe vera gel for treating acne erythema in 30 patients. Both treatments significantly reduced acne erythema, with the laser showing a faster clinical response. No serious adverse events were observed.
A Split-Mouth, Randomized, Double-Blind Clinical Trial of a Gelatin Hemostatic Dental Sponge Containing Aloe Vera Nanoparticles for Controlling Bleeding After Mandibular Posterior Teeth Extraction.
A split-mouth, randomized, double-blind clinical trial was conducted on 30 patients to evaluate the bleeding control of a hemostatic gelatin sponge containing aloe vera nanoparticles after mandibular posterior teeth extraction. The test group showed better efficiency in controlling bleeding compared to the control group, as indicated by lower mean excess blood weight.
Decreased inflammatory biomarkers after using artificial tears withand hypromellose for dry eye.
A three-month prospective, randomized, double-masked, placebo-controlled study on 20 dry eye patients evaluated the anti-inflammatory effects of artificial tears containing Aloe vera and hypromellose. The treatment showed beneficial effects on concentrations of MMP-9 and IL-6 in tears, tear break-up time, and ocular symptoms of dryness and irritation after three months.
The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
RCT evaluating the effect of Aloe vera gel (AVG) on quality of life in 42 patients with systolic heart failure. AVG group showed significant improvements in MLHFQ and NYHA class scores, reduced insomnia severity, and improved sleep quality. Fewer adverse events were reported in the AVG group.
Rapid increase in immune surveillance and expression of NKT and γδT cell activation markers after consuming a nutraceutical supplement containing Aloe vera gel, extracts of Poria cocos and rosemary. A randomized placebo-controlled cross-over trial.
A randomized, double-blind, placebo-controlled, cross-over trial in 11 healthy subjects evaluated the acute impact of a nutraceutical blend containing Aloe vera, Poria cocos, and rosemary on immune surveillance. The study found that consumption of the blend triggered rapid increases in chemokine levels and immune cell activation markers, suggesting enhanced natural immune surveillance and antioxidant protection.
Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash with chlorhexidine in fixed orthodontic patients-A randomized controlled trial.
This randomized controlled trial compared the antiplaque and anti-gingivitis effects of aloe vera mouthwash with chlorhexidine in 30 subjects undergoing fixed orthodontic treatment. Aloe vera showed promising results in reducing plaque and gingivitis scores, although chlorhexidine remains the gold standard.
Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study.
Prospective clinical study comparing the efficacy of black turmeric (Kali Haldi) and aloe vera gel mixture versus steroid therapy in 42 patients with oral submucous fibrosis. The ayurvedic regimen showed better symptomatic correction than steroid therapy over 3 months.
A comparison of the efficacy of silicone gel containing onion extract and aloe vera to silicone gel sheets to prevent postoperative hypertrophic scars and keloids.
RCT comparing silicone gel containing onion extract and aloe vera (SGOA) to silicone gel sheets (SGS) for preventing postoperative hypertrophic scars and keloids in 40 patients. No significant difference in scarring incidence, but SGOA showed higher pliability. Both treatments reduced pain and itchiness.
Clinical Efficacy of Aloe Vera Toothpaste on Periodontal Parameters of Patients with Gingivitis-A Randomized, Controlled, Single-masked Clinical Trial.
This randomized, controlled, single-masked clinical trial assessed the effects of aloe vera toothpaste on dental plaques and gingivitis in 20 dental students. The study found no significant improvement in plaque index and gingival index scores with aloe vera toothpaste compared to fluoride toothpaste, suggesting aloe vera toothpaste can be an alternative to chemical toothpaste.
Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial.
RCT of 20 colorectal cancer patients undergoing radiotherapy, randomized to receive Aloe vera 3% or placebo ointment. Aloe vera significantly improved diarrhea symptoms, lifestyle scores, and reduced depression scores and CRP levels, indicating reduced inflammation.
The effect of acemannan in implant placement with simultaneous guided bone regeneration in the aesthetic zone: a randomized controlled trial.
RCT investigating the impact of acemannan in guided bone regeneration with simultaneous implant placement in 20 patients. The test group with acemannan showed significantly smaller dimensional reduction of buccal bone at 3 months postoperative compared to control, but not at 6 months.
A Randomized Controlled Trial of a Herbal Compound for Improving Metabolic Parameters in Diabetic Patients with Uncontrolled Dyslipidemia.
RCT investigating a polyherbal compound on diabetic patients with uncontrolled dyslipidemia. The intervention group showed significant improvements in serum triglyceride, total cholesterol, low-density lipoprotein, and HbA1c levels, but no significant effect on fasting blood glucose. The compound did not adversely affect kidney function or liver enzymes.
Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy.
Double-blinded, randomized clinical trial comparing liposome-encapsulated Aloe vera gel extract (AGE) to AGE alone in 180 pregnant women with melasma. The liposomal-AGE group showed a 32% improvement in the Melasma Area Severity Index (MASI) score compared to a 10% improvement in the control group, indicating superior efficacy in reducing melasma severity.
Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study.
RCT evaluating aloe vera and myrrh-based oral mucoadhesive gels for minor recurrent aphthous stomatitis in 90 subjects. Aloe vera gel showed complete ulcer healing in 76.6% of patients and reduced erythema and exudation, while myrrh gel significantly reduced pain. No side effects were reported.
Intestinal Drug Absorption Enhancement by Aloe vera Gel and Whole Leaf Extract: In Vitro Investigations into the Mechanisms of Action
In vitro study investigating the absorption enhancement mechanisms of Aloe vera gel and whole leaf extract on drug permeation across intestinal epithelial barriers. The study found that Aloe vera decreased transepithelial electrical resistance and enhanced paracellular transport of smaller molecular weight compounds, indicating tight junction modulation as the mechanism of action.