Research
Agmatine Sulfate
26 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Exploring the Cardiovascular Impacts of Agmatine: A Systematic Review.
Systematic review of 60 preclinical studies exploring the cardiovascular effects of agmatine. Agmatine demonstrated dual effects on blood pressure and heart rate, depending on dose, administration route, and receptor pathways.
Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial.
This study assessed the safety and efficacy of dietary agmatine sulfate in herniated lumbar disc-associated radiculopathy. An open-label dose escalation study was followed by a randomized, double-blind, placebo-controlled trial. Agmatine sulfate showed significant improvement in pain and quality of life measures compared to placebo, with no treatment-related adverse events.
Injectable poloxamer-based thermogel as a delivery platform for agmatine and hyaluronic acid in muscle tissue engineering.
The study investigates an injectable poloxamer-based thermogel for delivering agmatine sulfate and hyaluronic acid to promote neuromuscular regeneration in a rat model of volumetric muscle loss. The combination therapy restored grip strength and normalized gait parameters, with histopathological analysis showing near-complete restitution of muscle architecture.
Evidence for safety of the dietary ingredient agmatine sulfate as assessed by mutagenicity and genotoxicity studies
The study assessed the safety profile of agmatine sulfate using in vitro and in vivo mutagenicity and genotoxicity tests. G-Agmatine® showed no mutagenic, clastogenic, or genotoxic effects, supporting its safety as a dietary ingredient.
Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis
The study investigates the role of the gut microbiota-derived metabolite agmatine in colorectal cancer (CRC) using a mouse model. Agmatine was found to interact with Rnf128, affecting β-catenin signaling and promoting inflammation, which contributes to colorectal carcinogenesis.
Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain
The study investigates the role of GluN2B-containing NMDA receptors in agmatine's ability to inhibit neuropathic pain development in a spared nerve injury model in mice. Agmatine reduced tactile hypersensitivity in control mice but not in those with reduced GluN2B subunits, indicating its dependence on these receptors for its analgesic effects.
Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study.
Open-label consecutive case series study evaluating the effectiveness of agmatine sulfate in neuropathies associated with painful small fiber neuropathy. Participants treated with 2.67 g/day agmatine sulfate showed a 46.4% reduction in neuropathic pain intensity. The study suggests significant pain reduction with agmatine sulfate.
Agmatine Improves the Behavioral and Cognitive Impairments Associated with Chronic Gestational Ethanol Exposure in Rats.
The study evaluated the effects of agmatine on cognitive deficits in rat offspring prenatally exposed to ethanol, modeling fetal alcohol spectrum disorder (FASD). Agmatine administration improved anxiety, depression-like behavior, and memory in these offspring, suggesting its therapeutic potential for cognitive impairment and neurological complications associated with FASD.
Neuroprotective action of agmatine in rotenone-induced model of Parkinson's disease: Role of BDNF/cREB and ERK pathway.
The study investigates the neuroprotective effects of agmatine in a rotenone-induced Parkinson's disease model. Agmatine at 100 mg/kg i.p. mitigated oxidative damage, alleviated motor impairments, decreased neuronal loss, and increased cREB, BDNF, and ERK1/2 expression in the striatum, highlighting its role in neuroplasticity and neuronal cell survival.
Agmatine Ameliorates Manifestation of Depression-like Behavior and Hippocampal Neuroinflammation in Mouse Model of Alzheimer's disease.
The study investigated the role of the agmatinergic system in β-amyloid peptide-induced depression in mice. Agmatine administration reduced depression-like behavior and neuroinflammatory markers, suggesting its potential as a therapeutic target for Alzheimer's disease-associated depression.
Agmatine Modulates Anxiety and Depression-like Behaviour in Diabetic Insulin-Resistant Rats.
The study investigated the role of agmatine in T2DM-induced depression and anxiety in rats. Agmatine administration reduced depression-like behaviors, anxiety, and neuroinflammatory markers in diabetic insulin-resistant rats, suggesting its potential as a therapeutic target for T2DM-associated mood disorders.
Agmatine alleviates hepatic and renal injury in a rat model of obstructive jaundice
The study evaluated the effects of agmatine supplementation on hepatic and renal injury in a rat model of obstructive jaundice. Agmatine significantly alleviated cholestasis-induced injury, likely due to its antioxidant properties and positive effects on mitochondrial indices.
Protective effect of agmatine against hyperoxia-induced acute lung injury via regulating lncRNA gadd7.
The study investigates the protective effect of agmatine (AGM) on hyperoxia-induced acute lung injury. It suggests that AGM decreases the expression of lncRNA gadd7, which in turn regulates MFN1 expression to inhibit cell apoptosis, thereby protecting against lung injury.
Amelioration of anti-inflammatory properties of Acetaminophen by Agmatine sulphate
Animal study investigating the anti-inflammatory effect of acetaminophen combined with agmatine sulfate in male rats with gouty arthritis. The combination showed significant improvements in inflammatory markers and joint stiffness, suggesting agmatine enhances acetaminophen's anti-inflammatory properties.
Agmatine Administration Effects on Equine Gastric Ulceration and Lameness
Study on the effects of agmatine sulfate on equine lameness and gastric ulceration. Six thoroughbred horses with thoracic limb osteoarthritis received agmatine, phenylbutazone, or control treatments. Agmatine improved thoracic limb ground reaction forces and reduced glandular mucosal ulcer scores compared to phenylbutazone.
Agmatine as a novel candidate for rapid-onset antidepressant response
This narrative review discusses agmatine as a potential rapid-onset antidepressant, highlighting its mechanisms involving glutamatergic modulation, anti-inflammatory properties, and effects on gut microbiota. The review suggests agmatine's fast antidepressant-like effects in animal models warrant further clinical investigation.
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy
The study developed a high-throughput screen using E. coli and C. elegans to explore host-microbe-drug-nutrient interactions affecting metformin therapy. It predicts microbial agmatine as a regulator of metformin's effects on host lipid metabolism and lifespan, suggesting potential for targeted microbiome therapies.
Safety and neurochemical profiles of acute and sub-chronic oral treatment with agmatine sulfate
The study investigated the safety, tolerability, and neurochemical profiles of oral agmatine sulfate treatment in wild-type and transgenic mice. Agmatine treatment was well tolerated with no behavioral impairments or pathological alterations. It increased agmatine levels in the brain and plasma, suggesting it crosses the blood-brain barrier and accumulates in the brain.
Agmatine for Pain Management in Dogs With Coxofemoral Joint Osteoarthritis: A Pilot Study
Pilot study comparing agmatine and carprofen for pain management in dogs with coxofemoral joint osteoarthritis. Agmatine improved ground reaction forces in dogs with mild CFJ OA compared to carprofen or placebo, while carprofen showed better results in dogs with moderate CFJ OA or IVD degeneration.
Single administration of agmatine reverses the depressive‐like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine
The study investigates the effects of a single administration of agmatine on depressive-like behavior induced by corticosterone in mice. Agmatine reversed the depressive-like behavior in the tail suspension test, showing a fast-acting antidepressant profile similar to ketamine, while fluoxetine did not show the same effect.
Effect of Agmatine Sulfate on Neuropathic Pain (P7.094)
Prospective study evaluating the effect of agmatine sulfate on neuropathic pain in patients with small fiber neuropathy. Significant decreases in burning, tingling, and unpleasant aspects of pain were observed, along with a decrease in total Discriminant Function scores after two months of treatment.
Agmatine augmentation in treatment-resistant obsessive-compulsive disorder: a prospective open-label case series
Prospective open-label case series evaluating agmatine sulfate augmentation in treatment-resistant OCD. Five adults with OCD were treated with agmatine sulfate, showing a gradual symptom reduction with a 40% responder rate. Agmatine was well-tolerated with mild transient gastrointestinal symptoms in two patients.
Neuroprotective offerings by agmatine.
The review discusses the neuroprotective effects of agmatine, an endogenous polyamine, in various CNS cell lines and animal models. It highlights agmatine's potential mechanisms of action, including its roles as a glutamatergic receptor antagonist, α2-adrenoceptor agonist, and antioxidant, among others. The review suggests potential use of agmatine for neuronal damage and neurodegenerative diseases, while noting the need for further research on dosage and pharmacokinetics.
Effects of agmatine on cognitive functions during vascular dementia in biological aging through eNOS and BDNF expression
The study examined the effects of agmatine on cognitive functions and vascular endothelial dysfunction in aged rats. Agmatine treatment improved cognitive performance, endothelial function, and regulated eNOS and BDNF protein expression, suggesting potential therapeutic benefits for vascular dementia.
Neuroprotective Role of Agmatine in Neurological Diseases
This review focuses on the neuroprotective actions of agmatine and its potential mechanisms in neurological diseases. Agmatine shows neuroprotective effects in conditions like stroke, traumatic brain injury, Parkinson's disease, and Alzheimer's disease through mechanisms such as anti-oxidation, anti-apoptosis, anti-inflammation, BBB protection, and brain edema prevention.
Selective inhibition of inducible nitric oxide synthase by agmatine.
The study investigates the inhibitory effect of agmatine on inducible nitric oxide synthase (iNOS) in isolated rat aorta and macrophages. Agmatine was found to be as potent as aminoguanidine in inhibiting iNOS activity, suggesting its role as an endogenous inhibitor.