Research
Agaricus
15 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Consuming Mushrooms When Adopting a Healthy Mediterranean-Style Dietary Pattern Does Not Influence Short-Term Changes of Most Cardiometabolic Disease Risk Factors in Healthy Middle-Aged and Older Adults.
RCT assessing the effects of consuming mushrooms as part of a Mediterranean-style diet on cardiometabolic risk factors in 60 healthy middle-aged and older adults. The MED-mushroom diet improved fasting serum glucose but did not influence other CMD risk factors.
Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial
RCT of 60 blood donors with birch pollen allergy testing oral supplementation with Agaricus blazei-based extract AndosanTM. The AbM group showed reduced allergy and asthma symptoms, lower specific IgE levels, and less sensitization to allergens compared to placebo during pollen season.
Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn’s Disease in a Randomized Single-Blinded Placebo Controlled Study
This randomized single-blinded placebo-controlled study examined the effects of AndoSanTM, based on Agaricus blazei Murill, on symptoms, fatigue, and quality of life in 50 patients with Crohn's disease. The AndoSanTM group showed significant improvement in symptoms, but no significant differences between the groups were found. Improvements in fatigue and HRQoL were similar to placebo.
Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study
Randomized single-blinded placebo-controlled study of 50 patients with ulcerative colitis examining the effects of AndoSan™, a mushroom extract based on Agaricus blazei Murill. The AndoSan™ group showed significant improvements in symptoms, fatigue, and health-related quality of life compared to placebo, with no reported harms.
Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan, in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study.
RCT examining the effects of Agaricus blazei Murill-based mushroom extract AndoSan on cytokine levels in 50 patients with Crohn's disease and ulcerative colitis. The study found limited reduction in systemic cytokine levels, suggesting marginal anti-inflammatory effects, with other mechanisms like anti-allergic and antioxidant activities potentially contributing to clinical benefits.
Effects of alpha-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs; a placebo-controlled study in slightly hypercholesterolemic subjects.
A double-blind randomized trial with 56 mildly hypercholesterolemic subjects evaluated the effects of consuming alpha-glucans from Agaricus bisporus on cytokine production by PBMCs. The intervention group showed a 69% reduction in LPS-induced TNFalpha production compared to the control group, with no effect on IL-1beta and IL-6, and no significant Th1-Th2 skewing.
The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.
RCT of 72 Chinese adults with type 2 diabetes comparing Agaricus blazei Murill extract to placebo for 12 weeks. The ABM group showed significantly lower HOMA-IR index and increased plasma adiponectin concentration, suggesting improved insulin resistance.
Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.
RCT involving 100 gynecological cancer patients undergoing chemotherapy, comparing those with and without oral consumption of Agaricus blazei Murill Kyowa (ABMK). The ABMK-treated group showed significantly higher natural killer cell activity and improved chemotherapy-associated side effects such as appetite, alopecia, emotional stability, and general weakness.
Impact of Agaricus bisporus Mushroom Consumption on Gut Health Markers in Healthy Adults.
A randomized open-label crossover study in 32 healthy adults compared the effects of consuming protein-matched amounts of Agaricus bisporus mushrooms versus meat on gut health markers. The mushroom diet led to greater gastrointestinal symptoms initially, higher stool weight, and altered fecal microbiota composition, with increased Bacteroidetes and decreased Firmicutes. No differences were found in breath hydrogen, stool frequency, consistency, fecal pH, or SCFA concentrations between diets.
Impact of Agaricus bisporus mushroom consumption on satiety and food intake.
Randomized open-label crossover study with 32 healthy participants comparing satiety and food intake between Agaricus bisporus mushrooms and meat. Participants reported less hunger and greater fullness after consuming mushrooms, but no significant differences in energy intake were observed over ten days. Mushroom consumption increased fiber intake, significantly on day 2.
A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus-induced prostate-specific antigen responses.
Phase I trial of white button mushroom (Agaricus bisporus) powder in 36 patients with biochemically recurrent prostate cancer. The study evaluated the effects on serum PSA levels and tolerability. An 11% overall PSA response rate was observed, with some patients achieving complete or partial response. Therapy was associated with declines in myeloid-derived suppressor cells and modulation of cytokine levels.
Dietary intake of Agaricus bisporus white button mushroom accelerates salivary immunoglobulin A secretion in healthy volunteers.
RCT with 24 healthy volunteers comparing normal diet with and without 100g daily intake of Agaricus bisporus white button mushroom (WBM) for 1 week. The WBM group showed a significant increase in salivary IgA secretion rate at weeks 1 and 2, indicating potential health benefits for improving mucosal immunity.
Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection.
The study investigated the effects of Agaricus blazei Murill extract on gene expression and viral load in four chronic hepatitis C patients. The viral load was slightly decreased after 1 week of treatment, but not significantly. Changes in mRNA levels were observed in genes related to G-protein coupled receptor signalling, cell cycling, and transcriptional regulation.
The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B.
This 1-year open-label pilot study observed the effects of Agaricus blazei Murill extract on liver function in 4 patients with chronic hepatitis B. The study found a decrease in aspartate aminotransferase and alanine aminotransferase levels, suggesting potential benefits in normalizing liver function.
Studies on the deodorization by mushroom (Agaricus bisporus) extract of garlic extract-induced oral malodor.
The study investigated the deodorizing effect of Agaricus bisporus (mushroom) extract on oral malodor induced by garlic consumption. Gas chromatography analysis showed a significant reduction in methane- and allylthiols after mushroom extract rinsing. In-vitro analysis suggested a faster reaction of methanethiol with mushroom extract compared to allylthiol.